Patents by Inventor Byung Hyun CHOI
Byung Hyun CHOI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11975076Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.Type: GrantFiled: November 12, 2021Date of Patent: May 7, 2024Assignee: LegoChem Biosciences, Inc.Inventors: Yong Zu Kim, Yeong Soo Oh, Jeiwook Chae, Ho Young Song, Chul-Woong Chung, Yun Hee Park, Hyo Jung Choi, Kyung Eun Park, Hyoungrae Kim, Jinyeong Kim, Ji Young Min, Sung Min Kim, Byung Soo Lee, Dong Hyun Woo, Ji Eun Jung, Su In Lee
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Patent number: 11970090Abstract: A railess variable seatback type rear seat includes: a linear movement device configured to convert a rotation of a motor into a linear movement; a sliding movement device configured to convert the linear movement into a sliding movement in which a seat cushion is pushed forward or backward; and a reclining angle change device configured to convert the sliding movement into a reclining movement, and to fold a seatback, which is connected to the seat cushion, forward or to recline the seatback backward.Type: GrantFiled: July 20, 2021Date of Patent: April 30, 2024Assignees: HYUNDAI MOTOR COMPANY, Kia Corporation, Daechang Seat Co.,LTD-Dongtan, Hyundai Transys Inc.Inventors: Seung-Hyun Kim, Sang-Hyun Lee, Min-Ju Lee, Byung-Yong Choi, Chan-Ho Jung, Seon-Chae Na, Young-Woon Choi, Jae-Jin Lee, Dong-Hwan Kim, In-Chang Hwang
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Publication number: 20240130111Abstract: A semiconductor device may comprise: a plurality of lower electrodes which are on a substrate; a first electrode support which is between adjacent lower electrodes and comprises a metallic material; a dielectric layer which is on the lower electrodes and the first electrode support to extend along profiles of the first electrode support and each of the lower electrodes; and an upper electrode which is on the dielectric layer.Type: ApplicationFiled: December 26, 2023Publication date: April 18, 2024Applicant: Samsung Electronics Co., Ltd.Inventors: Yoon Young CHOI, Seung Jin KIM, Byung-Hyun LEE, Sang Jae PARK
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Publication number: 20240082095Abstract: Disclosed is an exoskeleton-type rehabilitation robot system, including: a body part provided on a chair in which a user sits and provided with a robot arm capable of moving left or right based on the user seated on the chair; a conversion part configured to convert a position of the robot arm with respect to the body part; a driving part configured to articulate the robot arm with respect to the body part; and a controller configured to detect a change in a position of the robot arm and control a left or right driving mode of the driving part according to the position of the robot arm. In accordance with such a configuration, the exoskeleton-type rehabilitation robot system of the present invention is provided integrally with a chair, thereby having excellent space utilization. In addition, the user's initial preparation for rehabilitation training is simple, which can improve efficiency.Type: ApplicationFiled: December 27, 2021Publication date: March 14, 2024Applicant: HEXARHUMANCAR CO., LTDInventors: Chang Soo HAN, Ho Jun KIM, Su Hyun PARK, Young Hoon JI, Jeong Ho CHO, Byung Gab RYU, Jeong Gyu PARK, Dong Eun CHOI
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Publication number: 20240079642Abstract: The present invention relates to a method for preparing an alkali metal ion conductive chalcogenide-based solid electrolyte, a solid electrolyte prepared thereby, and an all-solid-state battery comprising the same.Type: ApplicationFiled: January 11, 2022Publication date: March 7, 2024Applicant: KOREA ELECTROTECHNOLOGY RESEARCH INSTITUTEInventors: Yoon Cheol HA, Sang Min LEE, Byung Gon KIM, Gum Jae PARK, Jun Woo PARK, Jun Ho PARK, Ji Hyun YU, Won Jae LEE, You Jin LEE, Hae Young CHOI
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Publication number: 20230212249Abstract: A method for producing a dual function protein includes a biologically active protein and an FGF21 mutant protein. The method allows stable production of a target protein by effectively preventing decomposition of the target protein, and thus has a high potential for commercial usage.Type: ApplicationFiled: December 19, 2022Publication date: July 6, 2023Applicant: YUHAN CORPORATIONInventors: Byung Hyun CHOI, In Hwan LIM, Jun Young PARK, Jin Hyoung LEE, Ki Hong KIM, Hae Yong JO, Jun Hwan KIM, Moo Young SONG, Jong Gyun KIM
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Patent number: 11560416Abstract: A method for producing a dual function protein includes a biologically active protein and an FGF21 mutant protein. The method allows stable production of a target protein by effectively preventing decomposition of the target protein, and thus has a high potential for commercial usage.Type: GrantFiled: April 20, 2018Date of Patent: January 24, 2023Assignee: YUHAN CORPORATIONInventors: Byung Hyun Choi, In Hwan Lim, Jun Young Park, Jin Hyoung Lee, Ki Hong Kim, Hae Yong Jo, Jun Hwan Kim, Moo Young Song, Jong Gyun Kim
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Patent number: 11505603Abstract: Disclosed are a novel antibody specifically binding to the tumor-immunosuppressant, TIGIT (T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif [ITIM] domain) or an antigen-binding fragment thereof, a nucleic acid encoding the antibody or the antigen-binding fragment thereof, a vector and a host cell including the nucleic acid, a method for producing the antibody or the antigen-binding fragment thereof, a pharmaceutical composition containing the antibody or the antigen-binding fragment thereof as an active ingredient, and uses of the pharmaceutical composition. The antibody specifically binding to TIGIT or the antigen-binding fragment thereof and the pharmaceutical composition containing the same as an active ingredient are preferably used for the treatment of cancer or tumors.Type: GrantFiled: February 28, 2019Date of Patent: November 22, 2022Assignee: YUHAN CORPORATIONInventors: Kwang-Hoon Lee, June Hyung Lee, Na Rae Lee, Eunjeong Jeong, Young Bong Park, Nakho Chang, Eun-Jung Lee, Ki Hong Kim, Sunghyun Choi, Byung Hyun Choi, Ju Young Park, Moo Young Song, Jong-Seo Lee, Kyu-Tae Kim, Bong-Kook Ko
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Patent number: 11479596Abstract: Disclosed are a fusion protein comprising a thyrotropin receptor (TSHR) fragment and the use thereof. More specifically, disclosed are a fusion protein comprising a TSHR fragment comprising an extracellular domain of a wild-type TSHR and having a substitution of an amino acid at specific position and an immunoglobulin Fc region or a carboxy-terminal cap (C-CAP), and the use thereof. The fusion protein has improved pharmaceutical efficacy, in-vivo persistence and protein stability and a pharmaceutical composition containing the fusion protein as an active ingredient is useful as a therapeutic agent or diagnostic reagent for the alleviation of Graves' disease and Graves' ophthalmopathy.Type: GrantFiled: July 24, 2019Date of Patent: October 25, 2022Assignees: YUHAN CORPORATION, INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITYInventors: Moo Young Song, Taejin Yoon, Jung-Sun Lee, Byung Hyun Choi, In Hwan Lim, Man Sil Park, Jin-Hyoung Lee, Hyoung Sig Seo, Hyeon Woo Kang, Sung Ho Kim, Eun Jig Lee, Jin Sook Yoon, Cheol Ryong Ku
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Publication number: 20220002367Abstract: A fusion protein comprises an FGF21 mutant protein and an Fc region of an immunoglobulin. The fusion protein exhibits improved pharmacological efficacy, in vivo duration and protein stability. A pharmaceutical composition containing the fusion protein as an active ingredient may be effectively used as a therapeutic agent for diabetes, obesity, dyslipidemia, metabolic syndrome, non-alcoholic fatty liver disease or non-alcoholic steatohepatitis.Type: ApplicationFiled: September 17, 2021Publication date: January 6, 2022Applicant: YUHAN CORPORATIONInventors: Jun Hwan KIM, Seyoung LIM, Minji SEO, Hyun Ho CHOI, Dohoon KIM, Mi Kyeong JU, Ju-Young PARK, Byung Hyun CHOI, Jun Kyung LEE, Jong Gyun KIM, Su Youn NAM
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Patent number: 11142557Abstract: The present invention provides a fusion protein comprising an FGF21 mutant protein and an Fc region of an immunoglobulin. The fusion protein according to the present invention exhibits improved pharmacological efficacy, in vivo duration and protein stability, and a pharmaceutical composition comprising the fusion protein as an active ingredient may be effectively used as a therapeutic agent for diabetes, obesity, dyslipidemia, metabolic syndrome, non-alcoholic fatty liver disease or non-alcoholic steatohepatitis.Type: GrantFiled: October 28, 2016Date of Patent: October 12, 2021Assignee: YUHAN CORPORATIONInventors: Jun Hwan Kim, Seyoung Lim, Minji Seo, Hyun Ho Choi, Dohoon Kim, Mi Kyeong Ju, Ju-Young Park, Byung Hyun Choi, Jun Kyung Lee, Jong Gyun Kim, Su Youn Nam
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Publication number: 20210221869Abstract: Disclosed are a fusion protein comprising a thyrotropin receptor (TSHR) fragment and the use thereof. More specifically, disclosed are a fusion protein comprising a TSHR fragment comprising an extracellular domain of a wild-type TSHR and having a substitution of an amino acid at specific position and an immunoglobulin Fc region or a carboxy-terminal cap (C-CAP), and the use thereof. The fusion protein has improved pharmaceutical efficacy, in-vivo persistence and protein stability and a pharmaceutical composition containing the fusion protein as an active ingredient is useful as a therapeutic agent or diagnostic reagent for the alleviation of Graves' disease and Graves' ophthalmopathy.Type: ApplicationFiled: July 24, 2019Publication date: July 22, 2021Inventors: Moo Young SONG, Taejin YOON, Jung-Sun LEE, Byung Hyun CHOI, In Hwan LIM, Man Sil PARK, Jin-Hyoung LEE, Hyoung Sig SEO, Hyeon Woo KANG, Sung Ho KIM, Eun Jig LEE, Jin Sook YOON, Cheol Ryong KU
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Patent number: 11046742Abstract: Provided are a fusion protein having a CCL3 variant with improved in vivo persistency, protein stability and pharmacological activity and a use thereof, more particularly, a fusion protein comprising a CCL3 variant and an immunoglobulin Fc region and a use thereof as a therapeutic agent for lymphopenia, cancer or infection, in which an N-terminal amino acid of a wild-type CCL3? or CCL3? is deleted and an amino acid at a specific position is substituted with a different amino acid at the same position of the wild-type CCL3? or CCL3? in the CCL3 variant.Type: GrantFiled: April 19, 2017Date of Patent: June 29, 2021Assignee: YUHAN CORPORATIONInventors: Su Youn Nam, Jong Gyun Kim, Byung Hyun Choi, June Hyung Lee, Ju Young Park, Jun Kyung Lee, Na Rae Lee, Ki Hong Kim, Seul Gi Kim, Se Woong Oh, Seung Yub Shin, Ho Woong Kang, Su Jin Ahn, Soo Yong Chung
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Publication number: 20210188936Abstract: A method for producing a dual function protein includes a biologically active protein and an FGF21 mutant protein. The method allows stable production of a target protein by effectively preventing decomposition of the target protein, and thus has a high potential for commercial usage.Type: ApplicationFiled: April 20, 2018Publication date: June 24, 2021Applicant: YUHAN CORPORATIONInventors: Byung Hyun CHOI, In Hwan LIM, Jun Young PARK, Jin Hyoung LEE, Ki Hong KIM, Hae Yong JO, Jun Hwan KIM, Moo Young SONG, Jong Gyun KIM
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Publication number: 20210087268Abstract: Disclosed are a novel antibody specifically binding to the tumor-immunosuppressant, TIGIT (T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif [ITIM] domain) or an antigen-binding fragment thereof, a nucleic acid encoding the antibody or the antigen-binding fragment thereof, a vector and a host cell including the nucleic acid, a method for producing the antibody or the antigen-binding fragment thereof, a pharmaceutical composition containing the antibody or the antigen-binding fragment thereof as an active ingredient, and uses of the pharmaceutical composition. The antibody specifically binding to TIGIT or the antigen-binding fragment thereof and the pharmaceutical composition containing the same as an active ingredient are preferably used for the treatment of cancer or tumors.Type: ApplicationFiled: February 28, 2019Publication date: March 25, 2021Inventors: Kwang-Hoon LEE, June Hyung LEE, Na Rae LEE, Eunjeong JEONG, Young Bong PARK, Nakho CHANG, Eun-Jung LEE, Ki Hong KIM, Sunghyun CHOI, Byung Hyun CHOI, Ju Young PARK, Moo Young SONG, Jong-Seo LEE, Kyu-Tae KIM, Bong-Kook KO
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Publication number: 20190153055Abstract: Provided are a fusion protein having a CCL3 variant with improved in vivo persistency, protein stability and pharmacological activity and a use thereof, more particularly, a fusion protein comprising a CCL3 variant and an immunoglobulin Fc region and a use thereof as a therapeutic agent for lymphopenia, cancer or infection, in which an N-terminal amino acid of a wild-type CCL3? or CCL3? is deleted and an amino acid at a specific position is substituted with a different amino acid at the same position of the wild-type CCL3? or CCL3? in the CCL3 variant.Type: ApplicationFiled: April 19, 2017Publication date: May 23, 2019Inventors: Su Youn Nam, Jong Gyun Kim, Byung Hyun Choi, June Hyung Lee, Ju Young Park, Jun Kyung Lee, Na Rae Lee, Ki Hong Kim, Seul Gi Kim, Se Woong Oh, Seung Yub Shin, Ho Woong Kang, Su Jin Ahn, Soo Yong Chung
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Publication number: 20180305428Abstract: The present invention provides a fusion protein comprising an FGF21 mutant protein and an Fc region of an immunoglobulin. The fusion protein according to the present invention exhibits improved pharmacological efficacy, in vivo duration and protein stability, and a pharmaceutical composition comprising the fusion protein as an active ingredient may be effectively used as a therapeutic agent for diabetes, obesity, dyslipidemia, metabolic syndrome, non-alcoholic fatty liver disease or non-alcoholic steatohepatitis.Type: ApplicationFiled: October 28, 2016Publication date: October 25, 2018Applicant: YUHAN CORPORATIONInventors: Jun Hwan KIM, Seyoung LIM, Minji SEO, Hyun Ho CHOI, Dohoon KIM, Mi Kyeong JU, Ju-Young PARK, Byung Hyun CHOI, Jun Kyung LEE, Jong Gyun KIM, Su Youn NAM
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Patent number: 9543592Abstract: Provided is a method of manufacturing an anode core-shell complex for a solid oxide fuel cell, including (A) manufacturing a stabilized zirconia (YSZ) sol by using zirconium hydroxide (Zr(OH)4) and yttrium nitrate (Y(NO3)3.6H2O) as a starting material and distilled water as a solvent by a hydrothermal method, (B) agitating nickel chloride, stabilized zirconia in a sol state, and a surfactant, (C) adding sodium hydroxide (NaOH), (D) adjusting a pH to a range of 6 to 8, and (E) sintering the nickel-stabilized zirconia core-shell powder.Type: GrantFiled: November 25, 2013Date of Patent: January 10, 2017Assignee: KOREA INSTITUTE OF CERAMIC ENGINEERING AND TECHNOLOGYInventors: Byung Hyun Choi, Mi Jung Ji, Min Jin Lee, Sun Ki Hong, Young Jin Kang
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Patent number: 9050776Abstract: The present disclosure relates to a method of synthesis of Lithium Titanate Oxide used for a cathode of Lithium ion battery, the method comprising: (A) diluting TiCl4 with TiOCl2; (B) adding YCl3 or NbCl5 at the rate of 0.1˜2 mol % to Ti(mol); (C) forming a complex salt by dissolving to put at least one selected from a group consisting of Hydroxy propyl cellulose or Polyethylene glycol in a solvent, the Hydroxy propyl cellulose being a complexing agent and being a dispersing agent as well, whereas the Polyethylene glycol being a dispersing agent; (D) synthesizing a titanium precursor by adding an aqueous ammonia solution; (E) preparing Y or Nb doped titanium dioxide(TiO2) powder by heat-treating the synthetic product in a temperature of 500˜700° C.; and (F) mixing the Y or Nb doped TiO2 powder with LiOH.H2O and heat-treating the mixture in a temperature of 800˜900° C.Type: GrantFiled: August 31, 2012Date of Patent: June 9, 2015Assignee: KOREA INSTITUTE OF CERAMIC ENGINEERING AND TECHNOLOGYInventors: Byung Hyun Choi, Mi Jung Ji, Eun Kyung Kim, Young Jin Kwon, Sung Hun Jung, Yong Tae An
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Publication number: 20140342269Abstract: Provided is a method of manufacturing an anode core-shell complex for a solid oxide fuel cell, including (A) manufacturing a stabilized zirconia (YSZ) sol by using zirconium hydroxide (Zr(OH)4) and yttrium nitrate (Y(NO3)3.6H2O) as a starting material and distilled water as a solvent by a hydrothermal method, (B) agitating nickel chloride, stabilized zirconia in a sol state, and a surfactant, (C) adding sodium hydroxide (NaOH), (D) adjusting a pH to a range of 6 to 8, and (E) sintering the nickel-stabilized zirconia core-shell powder.Type: ApplicationFiled: November 25, 2013Publication date: November 20, 2014Applicant: KOREA INSTITUTE OF CERAMIC ENGINEERING AND TECHNOLOGYInventors: Byung Hyun CHOI, Mi Jung JI, Min Jin LEE, Sun Ki HONG, Young Jin KANG