Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: A video data service system includes a web server for providing a web page which authenticates a member as a copyright holder and registers the member as a first member; an encoding server for inserting an identifier representing the copyright holder corresponding to the first member into first format video data uploaded from the first member, and for encoding the first format video data into second format video data; a media file server for storing therein the encoded second format video data; and a database server for storing therein first member information inputted by the first member and link information for accessing the second format video data on a web. The link information is transmitted to a video data distribution system through the web server.