Abstract: The present invention relates to a peptide for promoting bone formation or inhibiting bone resorption and use thereof. The peptide for regulating bone formation or bone resorption of the present invention has the effect of promoting bone formation by enhancing osteoblast differentiation and concurrently inhibiting bone resorption by restricting osteoclast differentiation and resorptive function. Additionally, due to the low molecular weight, the peptide can be economically produced, and is thus useful for preventing and treating bone diseases.

Abstract: The present invention relates to a peptide for promoting bone formation or inhibiting bone resorption and use thereof. The peptide for regulating bone formation or bone resorption of the present invention has the effect of promoting bone formation by enhancing osteoblast differentiation and concurrently inhibiting bone resorption by restricting osteoclast differentiation and resorptive function. Additionally, due to the low molecular weight, the peptide can be economically produced, and is thus useful for preventing and treating bone diseases.

Abstract: The present invention relates to human laminin ?2 chain LG3 domain and active peptides promoting cell adhesion, spreading, migration, and neurite outgrowth. More particularly, it was found that when nerve cells are incubated using human laminin ?2 chain LG3 domain and active peptides in the LG3 domain, cell adhesion, spreading, migration, and neurite outgrowth of nerve cells promote and the promotion of cell adhesion, spreading, migration, and neurite outgrowth of nerve cells are integrin-mediated and achieved by the activation of PKC? and FAK phosphorylation. Thus, the present invention can be very useful for researches on cell adhesion, spreading, migration, and neurite outgrowth activities of cells which are focused on nerve cells and mediated by various extracellular matrix proteins including laminin, manufacture of artificial nerve conduits, burns treatment, wounds treatment, and tissue regeneration.

Abstract: The present invention relates to human laminin ?2 chain LG3 domain and active peptides promoting cell adhesion, spreading, migration, and neurite outgrowth. More particularly, it was found that when nerve cells are incubated using human laminin ?2 chain LG3 domain and active peptides in the LG3 domain, cell adhesion, spreading, migration, and neurite outgrowth of nerve cells promote and the promotion of cell adhesion, spreading, migration, and neurite outgrowth of nerve cells are integrin-mediated and achieved by the activation of PKC? and FAK phosphorylation. Thus, the present invention can be very useful for researches on cell adhesion, spreading, migration, and neurite outgrowth activities of cells which are focused on nerve cells and mediated by various extracellular matrix proteins including laminin, manufacture of artificial nerve conduits, burns treatment, wounds treatment, and tissue regeneration.

Abstract: The present invention relates to a peptide promoting cell adhesion and spreading, fragments, and derivatives thereof, more particularly, integrin-?3?1-dependent peptide in human laminin-5 ?3 chain LG3 domain, mediating integrin ?3?1 binding and cell adhesion and spreading, fragments and derivatives thereof. The inventive peptide, fragments and derivatives thereof can be used effectively for research on cell adhesion activity, wound care, tissue regeneration, inhibition of cancer metastesis etc. mediated by various extracellular matrix protein including laminin.

Abstract: The present invention relates to a peptide promoting cell adhesion and spreading, fragments, and derivatives thereof, more particularly, integrin-?3?1-dependent peptide in human laminin-5 ?3 chain LG3 domain, mediating integrin ?3?1 binding and cell adhesion and spreading, fragments and derivatives thereof. The inventive peptide, fragments and derivatives thereof can be used effectively for research on cell adhesion activity, wound care, tissue regeneration, inhibition of cancer metastesis etc. mediated by various extracellular matrix protein including laminin.

Abstract: A switched-capacitor circuit for sampling a pair of differential input signals includes a first bootstrapped switch and a first non-boosted switch connected in parallel between a first output terminal of an amplifier and a first feedback node of the switched-capacitor circuit to form a first feedback signal path and a second bootstrapped-switch and a second non-boosted switch connected in parallel between a second output terminal of the amplifier and a second feedback node of the switched-capacitor circuit to form a second feedback signal path. The first and second non-boosted switches are controlled by a first clock signal and the first and second bootstrapped switches are controlled by a second clock signal where the second clock signal is the first clock signal delayed by a predetermined amount.

Abstract: An operational amplifier includes a pair of differential input transistors, a pair of cascode transistors and a keep-alive circuit. The pair of differential input transistors is connected together at the source terminals and the gate terminals of the input transistors receive a pair of differential input signals. Each cascode transistor is connected to a respective input transistor to form a cascode. The drain terminals of the pair of cascode transistors provide a pair of differential output signals. The keep-alive circuit is connected to provide first and second bias currents to the source terminals of the pair of cascode transistors. In operation, each of the first and second bias currents is a variable current being a function of a voltage at the source terminal of the respective cascode transistor. The first and second bias currents keep the pair of cascode transistors alive during transient overload conditions.

Abstract: A first stage circuit for a high-speed, high-resolution pipeline analog-to-digital converter (ADC) implements operational amplifier (opamp) sharing and capacitor sharing to combine the sample-and-hold (SAH) and the MDAC (multiplying digital to analog converter) functions in the first residue stage of the pipeline ADC. In one embodiment, the first stage circuit includes a sampling capacitor, an amplifier, a feedback capacitor array and a comparator. The sampling capacitor and the feedback capacitor array are configured by switches to operate in a sampling/MDAC mode, a discharge mode and a hold mode. In this manner, the sample-and-hold operation and the MDAC operation are merged into the first stage circuit of the pipeline ADC to achieve low power and high speed of operation.

Abstract: The present invention provides an apparatus and method for reducing and canceling 1/f noise, offset voltage, and charge injection introduced in pipeline ADCs in conventional op-amp sharing techniques. The polarity of the residue signals is changed at each phase. During phase one, the residue signal of the operational amplifier is sampled on the capacitors with inverse polarity. During phase 2 the residue signal of the operational amplifier is sampled on the capacitors with the inverse polarity of phase one.

Abstract: A TFT-LCD driver includes a TFT-LCD panel having a plurality of gate bus lines, a plurality of source bus lines, a plurality of TFT's, and a plurality of liquid crystal cells corresponding to the plurality of TFT's, a gate driver integrated circuit for supplying driving voltages to the gate bus lines to turn the TFT's on and off, a source driver integrated circuit for sequentially supplying analog voltages to the source bus lines so as to input the analog voltages to the plurality of liquid crystal cells through the turned-on TFT's, and a controller for providing control signals to the gate driver integrated circuit and the source driver integrated circuit, wherein the analog voltages supplied from the source driver integrated circuit to the TFT-LCD panel have the same polarity at least twice in sequence, wherein the source driver integrated circuit drives the TFT-LCD panel using one of a dot inversion method and a pixel inversion method.

Abstract: Disclosed is an inhibitor of replicative senescence of human keratinocytes containing retinoic acid, including all-trans retinoic acid, 3,4-didehydroretinoic acid, and 9-cis retinoic acid, as active ingredients. The retinoic acid plays an important role in extending the in vitro life span and inhibiting replicative senescence of the human mucosal keratinocytes and the human epidermal keratinocytes, thereby being used for a prophylactic or therapeutic agent of various diseases attributed to replicative senescence of the human oral keratinocytes. In addition, the inhibitor containing the retinoic acid can be used for a cosmetic purpose and as a prophylactic or therapeutic agent for wound-caused dermatitis and ski senescence.

Abstract: A TFT-LCD driver includes a TFT-LCD panel having a plurality of gate bus lines, a plurality of source bus lines, a plurality of TFT's, and a plurality of liquid crystal cells corresponding to the plurality of TFT's, a gate driver integrated circuit for supplying driving voltages to the gate bus lines to turn the TFT's on and off, a source driver integrated circuit for sequentially supplying analog voltages to the source bus lines so as to input the analog voltages to the plurality of liquid crystal cells through the turned-on TFT's, and a controller for providing control signals to the gate driver integrated circuit and the source driver integrated circuit, wherein the analog voltages supplied from the source driver integrated circuit to the TFT-LCD panel have the same polarity at least twice in sequence, wherein the source driver integrated circuit drives the TFT-LCD panel using one of a dot inversion method and a pixel inversion method.

Abstract: Disclosed is an inhibitor of replicative senescence of human keratinocytes containing retinoic acid, including all-trans retinoic acid, 3,4-didehydroretinoic acid, and 9-cis retinoic acid, as active ingredients. The retinoic acid plays an important role in extending the in vitro life span and inhibiting replicative senescence of the human mucosal keratinocytes and the human epidermal keratinocyes, thereby being used for a prophylactic or therapeutic agent of various diseases attributed to replicative senescence of the human oral keratinocytes. In addition, the inhibitor containing the retinoic acid can be used for a cosmetic purpose and as a prophylactic or therapeutic agent for wound-caused dermatitis and ski senescence.

Abstract: The present invention provides a current comparator that reduces both input and output resistance. The current comparator positions a resistive feedback network in a first inverting amplifier of an input stage. The input stage according to the present invention can include a first and a second input terminal, an output terminal, a reference current source, a load circuit, a driving unit, and a resistive circuit. The reference current source supplies a reference current to the first input terminal. The load circuit supplies a first current to the output terminal. The first current is preferably equal to the reference current. The driving unit generates a prescribed output voltage by controlling the first current based on an input current applied to the second input terminal. The resistor is coupled between a control terminal of the driving unit, the second input terminal and the output terminal.

Abstract: A reliable digital-to-analog converter includes a coarse stage having 2M−1 number of first resistors and a fine stage coupled to the coarse stage in series for converting a digital signal of K(K=M+N) bit to an anoalog signal, where M equals the number of most significant bits and N equals the number of least significant bits. The fine stage coupled in series to the coarse stage has an equivalent resistance substantially equal to a resistance of any one of the first resistors of the coarse stage.

Abstract: The present invention relates to a new use of medium-chain fatty acids in prevention and treatment of dental caries and a pharmaceutical composition containing medium-chain fatty acids as active ingredients. Particularly, the present invention relates to the use of the salt form of medium-chain fatty acids; nonanoic acid, capric acid, undecanoic acid, lauric acid, tridecanoic acid or myristic acid, for prevention and treatment of dental caries and periodontal disease. The pharmaceutical composition containing medium-chain fatty acids as active ingredients may include lectins and/or fluoride in addition to medium-chain fatty acids.

Abstract: An oversampling digital/analog (D/A) converter is provided that has a reduced circuit area and an improved dynamic range of a converted voltage signal. The oversampling D/A converter includes an interpolation filter that receives a digital signal and oversamples the digital signal to provide a multibit digital signal. A digital noise shaper quantizes a noise contained in the digital signal passed through the interpolation filter, and an IFIR (Interpolated Finite Impulse Response) reconstruction filter converts a noise shaped digital signal in an analog signal corresponding to the noise shaped digital signal.

Abstract: Disclosed is a lens for treating the diplopia and amblyopia and glasses using the same including a concave and convex part wherein a concave part and a convex part are continuously and repeatedly formed on the overall surface of a lens body facing an eye ball of a person who wears the lens. Here, the concave pan has a radius of curvature of R and the convex part has a radius of curvature of r. The relation between R and r is R>>r. There is no esthetic defects ostensibly since an eye through the glasses using the lens look like a normal eye seen from the outside of the glasses and covers a normal eye on behalf of the conventional eye patch by hardly seeing an object of the outside seen from the inside of the glasses, thereby improving the eyesight of the patient suffering from the diplopia or the amblyopia.

Abstract: A bioabsorbable clamping apparatus for using in extraocular muscle surgery, for example, for curing strabismus is disclosed. The invention consists of two embodiments to be joined together. In one embodiment, a fixing means comprises two opposing bodies to be interlocked such as an upper fixing body and a lower fixing body. In another embodiment, a supporting body comprises two bodies, posteriorly connected along with above said bodies, such as the upper supporting body upholding and fastening the said upper fixing body, and a lower supporting body upholding and fastening the said lower fixing body. This invention provides for the muscle clamping apparatus wherein the said lower fixing body passes through the muscle to thereby cause the muscle to be connected together with the said upper fixing body when forcibly engaged to each other and to the said supporting body.