Abstract: The present disclosure relates to a method for carrying out dose delivery quality assurance for high-precision radiation treatment, in which parameters affecting a pass rate of dose delivery quality assurance can be derived through regression analysis, which is a known statistical analysis method, and a pass rate prediction model capable of predicting each parameter and the pass rate of dose delivery quality assurance can be derived, and accordingly, it can be predicted in advance whether dose delivery quality assurance will be passed according to the parameters through the above prediction model, without repeatedly carrying out dose delivery quality assurance according to a patient's treatment plan, and as a result, the efficiency of dose delivery quality assurance can be enhanced, and the time or capacity required for such quality assurance is reduced, such that radiation treatment for an actual patient can be quickly and precisely carried out.

Abstract: This invention relates to a series of substituted cyclohexane containing analogues which are agonists of GPR119 intended to treat metabolic diseases mediated by GPR119 including Type I & II diabetes mellitus. Diabetes mellitus is an ever-increasing threat to human health causing various complications (blindness, kidney failure, neuropathy, heart attack, stroke, etc.). Recently it was found that activation of GPR119 which is highly expressed in pancreatic beta cells causes glucose dependent insulin secretion and GLP-1 release. Many pharmaceuticals are currently developing GPR119 agonists and herein we disclose alternative GPR119 agonists. Our invention describes GPR119 agonists having structural Formula (I), pharmaceutically acceptable salt or solvate of Formula (I), isomer or prodrug of Formula (I), and combination therapy of Formula (I) with other anti-diabetic drugs like DPP-IV inhibitors and/or insulin sensitizers.

Abstract: A pedal driving mechanism for a bicycle which contains structurally improved pedal arms on which pedals are installed to increase the rotary radius of the pedals during the running of the bicycle to obtain optimum driving energy with minimum physical energy consumption, wherein the structure of pedaling mechanism defines a joining line formed by the tooth-coupling of a fixing gear and a rotary gear with the axle line of a driving arm at a right angle, and the trace of the linkage formed by a connection arm and a connection link is set to move in a spiral motion forced to rotate with respect to the center of the fixing gear.

Abstract: A pedal driving mechanism for a bicycle which contains structurally improved pedal arms on which pedals are installed to increase the rotary radius of the pedals during the running of the bicycle to obtain optimum driving energy with minimum physical energy consumption, wherein the structure of pedaling mechanism defines a joining line formed by the tooth-coupling of a fixing gear and a rotary gear with the axle line of a driving arm at a right angle, and the trace of the linkage formed by a connection arm and a connection link is set to move in a spiral motion forced to rotate with respect to the center of the fixing gear.

Abstract: A variable pedal driving device for a bicycle, the device allowing the bicycle pedals to slide along crankshafts during operation of the device. Each pedal is coupled to a slide pipe slidably mounted on a crankshaft. The slide pipe is in turn connected to an eccentric member mounted on the main shaft of the driving device. When a pedal is driven in a forward direction, the eccentric member causes the pedal to extend out to a maximum distance from the main shaft, for more efficient driving of the bicycle.