Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: Disk loading apparatus and method are provided. The disk loading apparatus includes a main chassis to which a transferring roller for transferring a disk is installed, a transmission unit installed to the main chassis for transferring a power to the transferring roller, a slider installed to the main chassis and moved in a direction of loading and unloading the disk, a first interlocking unit installed to the main chassis for guiding the disk into a chucking position, a second interlocking unit installed to the main chassis and operating in cooperation with the first interlocking unit and the slider, and a locking lever installed to the main chassis for selectively locking the first interlocking unit. It can reduce the number of components, and decrease a power loss generated at the transmission.

Abstract: Disk loading apparatus and method are provided. The disk loading apparatus includes a main chassis to which a transferring roller for transferring a disk is installed, a transmission unit installed to the main chassis for transferring a power to the transferring roller, a slider installed to the main chassis and moved in a direction of loading and unloading the disk, a first interlocking unit installed to the main chassis for guiding the disk into a chucking position, a second interlocking unit installed to the main chassis and operating in cooperation with the first interlocking unit and the slider, and a locking lever installed to the main chassis for selectively locking the first interlocking unit. It can reduce the number of components, and decrease a power loss generated at the transmission.

Abstract: A magnetic head has a titanium oxide layer and titanium layer between a chip core and a diamond-like carbon (DLC) layer, to improve adhesion between the DLC layer and the chip core and thereby prevent the separation of the DLC layer from the surface of the chip core.