Abstract: The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g.

Abstract: A multilayer capacitor includes a body including dielectric layers and internal electrodes and external electrodes disposed on an external surface of the body and connected to the internal electrodes. The body includes a first surface and a second surface to which the internal electrodes are exposed, the first surface and the second surface opposing each other in a first direction, a third surface and a fourth surface opposing each other in a second direction which is a direction in which the dielectric layers are stacked, and a fifth surface and a sixth surface opposing each other in a third direction. At least one of the internal electrodes include a first bottleneck structure having a first directional length of a third-directional outer region smaller than an inner region thereof and a second bottleneck structure having a third directional length of a first directional outer region smaller than an inner region thereof.

Abstract: The present disclosure relates to a container for retort food and, more specifically, to a container for retort food including: a container body in which food may be input and stored; and an inner cap covering the container body. The inner cap covering the container body has a predetermined depth, and thus, effective sterilization may be performed during a retort processing process, overflow of the food in the container body may be prevented, and there is an advantage in satisfying regulations regarding a packing space ratio.

Abstract: A laser apparatus includes a laser generator configured to generate a first laser beam proceeding along a first direction, and an inversion module configured to convert the first laser beam to a second laser beam proceeding along the first direction, the inversion module including a splitter configured to form a reflected laser beam by partially reflecting the first laser beam, and a transmitted laser beam by partially transmitting the first laser beam, and a prism configured to reflect the reflected laser beam.

Abstract: A method of removing a metal substance in a petrochemical product including: supplying a petrochemical product stream to an incoming tank through a supply pipe, circulating the petrochemical product stream through an incoming tank circulation pipe, and removing a metal substance included in the petrochemical product stream using a magnetic filter; transporting the petrochemical product stream to an outgoing tank through an incoming tank discharge pipe which is branched from the incoming tank circulation pipe and connected to an outgoing tank; circulating the petrochemical product stream through an outgoing tank circulation pipe provided in the outgoing tank and removing the metal substance included in the petrochemical product stream using a magnetic filter; and transporting the petrochemical product stream to a branch pipe branched from the outgoing tank circulation pipe to remove the metal substance using an ion exchange resin filter.

Abstract: A method of fabricating a capacitive micromachined ultrasonic transducer (CMUT) according to one aspect of the present invention may include forming, on a semiconductor substrate, a first region implanted with impurity ions at a first average concentration and a second region implanted with no impurity ions or implanted with the impurity ions at a second average concentration lower than the first average concentration, forming an insulating layer by oxidizing the semiconductor substrate wherein the insulating layer includes a first oxide layer having a first thickness on at least a part of the first region and a second oxide layer having a second thickness smaller than the first thickness on at least a part of the second region, and forming a membrane layer on the insulating layer such that a gap is defined between the second oxide layer and the membrane layer.

Abstract: The present disclosure relates to a cervical spine supporting pillow and a method of manufacturing the same, and more particularly, to a cervical spine supporting pillow including: a first support layer formed to have a predetermined area so that a cervical spine and an occipital region of a user may be seated thereon; a second support layer formed with a plurality of air vents in a front surface and a rear surface thereof; and a third support layer formed to support the first support layer and the second support layer, wherein the third support layer, the second support layer, and the first support layer are sequentially stacked from bottom to top.

Abstract: A coil component includes a body having a first surface, and a first end surface and a second end surface connected to the first surface and opposing each other in a length direction; a support substrate disposed inside the body; a coil portion comprising a first coil pattern and first and second lead-out patterns, each disposed on a first surface of the support substrate; first and second slit portions, respectively defined on edge portions of the first surface of the body to expose the first and second lead-out patterns; and first and second external electrodes disposed on the first and second slit portions to be connected to the first and second lead-out patterns. At least one of the first and second lead-out patterns has a thickness greater than a thickness of each of the first coil pattern and the first dummy lead-out pattern.

Abstract: According to an embodiment, a wick structure of a heat pipe that is capable of bending while increasing a heat transferring operation limit value is provided by improving the wick structure provided inside the heat pipe.

Abstract: Disclosed is an exoskeleton-type rehabilitation robot system, including: a body part provided on a chair in which a user sits and provided with a robot arm capable of moving left or right based on the user seated on the chair; a conversion part configured to convert a position of the robot arm with respect to the body part; a driving part configured to articulate the robot arm with respect to the body part; and a controller configured to detect a change in a position of the robot arm and control a left or right driving mode of the driving part according to the position of the robot arm. In accordance with such a configuration, the exoskeleton-type rehabilitation robot system of the present invention is provided integrally with a chair, thereby having excellent space utilization. In addition, the user's initial preparation for rehabilitation training is simple, which can improve efficiency.

Abstract: A stator for an electric motor and an electric motor including the same are provided. A stator for an electric motor according to an exemplary embodiment of the present invention includes at least one coil, and a stator core including a yoke formed in a non-circular closed loop shape with at least one straight line portion, and a slot portion extending inward from the yoke by a predetermined length, wherein the slot portion includes a plurality of first slots on which the coil is wound and a plurality of second slots on which the coil is not wound, and at least one first slot of the plurality of first slots and at least one second slot of the plurality of second slots form the same phase as each other.

Abstract: A cooling fan includes: a fan housing having an air outlet for discharging air and an air inlet for introducing air; a rotation shaft having a lower portion rotatably supported by the fan housing; a rotor fixed to an upper portion of the rotation shaft; a stator arranged inside the rotor with a predetermined gap with respect to the rotor; an impeller connected to an outer periphery of the rotor and rotated together with the rotor; a printed circuit board (PCB) arranged below the stator to connect power to the stator and having mounted thereon various circuit components of the motor driving circuit; and a PCB housing box connected to the rear surface of the fan housing through a plurality of bridges and accommodating the PCB in a center thereof.

Abstract: A coil component includes a body having one surface, and one end surface and the other end surface, respectively connected to the one surface and opposing each other, a support substrate embedded in the body, and a coil portion disposed on the support substrate and including first and second lead-out patterns respectively exposed from surfaces of the body. The first lead-out pattern is exposed from the one surface of the body and the one end surface of the body. The second lead-out pattern is exposed from the one surface of the body and the other end surface of the body. The body includes an anchor portion disposed in each of the first and second lead-out patterns.

Abstract: Provided are a hyperparameter optimizer and method for optimizing hyperparameters and a spiking neural network processing unit. The optimizer includes a statistical analyzer configured to receive training data and perform statistical analysis on the training data, an objective function generator configured to generate hyperparameter-specific objective functions by using a statistical analysis value of the statistical analyzer, and an optimal hyperparameter selector configured to select optimal hyperparameters according to certain rules on the basis of the hyperparameter-specific objective functions.

Abstract: A method of manufacturing a stacked structure includes forming a first metal buffer layer including crystal grains on a base substrate, forming a second metal buffer material layer on the first metal buffer layer, and crystallizing the second metal buffer material layer to form a second metal buffer layer, wherein the second metal buffer material layer includes crystal grains, and a density of the crystal grains of the second metal buffer material layer is lower than a density of the crystal grains of the first metal buffer layer.

Abstract: A method for producing CAR-M1 macrophages expressing a chimeric antigen receptor in vitro and in vivo includes using a conjugate of a non-viral gene delivery system and a chimeric antigen receptor gene. The CAR-M1 macrophages are produced in vivo by delivering genes encoding a chimeric antigen receptor and IFN-?, specifically to macrophages in the body, and thus does not require culturing and preparing an in-vitro cellular therapeutic agent, thus reducing the manufacturing costs of therapeutic agents. The CAR-M1 macrophages are a safer therapy since a non-viral vector is used, as compared to the production of CAR-M1 macrophages by gene delivery using a viral vector, and are a novel therapeutic candidate having the advantage of high anticancer efficiency for solid cancers, due to CAR-M1 macrophages in which intrinsic properties of macrophages infiltrating solid cancers and cancer cell phagocytosis are improved.

Abstract: A multilayer capacitor includes a body including dielectric layers and internal electrodes and external electrodes disposed on an external surface of the body and connected to the internal electrodes. The body includes a first surface and a second surface to which the internal electrodes are exposed, the first surface and the second surface opposing each other in a first direction, a third surface and a fourth surface opposing each other in a second direction which is a direction in which the dielectric layers are stacked, and a fifth surface and a sixth surface opposing each other in a third direction. At least one of the internal electrodes include a first bottleneck structure having a first directional length of a third-directional outer region smaller than an inner region thereof and a second bottleneck structure having a third directional length of a first directional outer region smaller than an inner region thereof.

Abstract: The present disclosure relates to a method for classifying instructions according to the number of operands required for processing-in-memory instruction processing, and a computing device applying same. Efficient instruction processing in a processing-in-memory may include identifying the number of operands required when processing an instruction queuing to be processed, interpreting the instruction queuing to be processed and processing an instruction corresponding to the identified number of required operands. When the number of required operands is 0, the instruction interpretation may interpret the instruction queuing to be processed as a WRITE instruction, and the instruction processing may execute memory writing. When the number of required operands is not 0, the instruction processing may execute memory reading in an internal memory of the processing-in-memory by the same number of times as the number of operands required in the instruction interpreted in the instruction interpretation.

Abstract: The present invention relates to a separator, a manufacturing method therefor, and a lithium secondary battery comprising the same, the separator comprising: a porous substrate; and a porous adhesive layer formed on one surface or both surfaces of the porous substrate, wherein the porous adhesive layer comprises a nitrogen-containing binder and polyvinylidene fluoride-based polymer microparticles having an average diameter of 200 nm to 700 nm, and the total thickness of the porous adhesive layer is 1 ?m or less.

Abstract: Provided are a separator for a rechargeable lithium battery and a rechargeable lithium battery comprising the same, the separator for a rechargeable lithium battery comprising a substrate and an adhesive coating layer, on one surface of the substrate, and comprising polymer clusters.