Patents by Inventor C. A. Higginbotham

C. A. Higginbotham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gastrin receptor-avid peptide conjugates
    Patent number: 6200546
    Abstract: A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.
    Type: Grant
    Filed: April 22, 1998
    Date of Patent: March 13, 2001
    Assignee: The Curators of the University of Missouri
    Inventors: Timothy J. Hoffman, Wynn A. Volkert, Ning Li, Gary Sieckman, C. A. Higginbotham