Abstract: The present invention relates to a method of modulating a chromatin binding protein or complex which binds to a functional group on an amino acid of a histone. This method involves phosphorylating or dephosphorylating a serine or threonine on the histone proximate to the amino acid under conditions effective to modulate the chromatin binding protein or complex. This method is particularly useful in treating or preventing cancer in a subject. In addition, the histone comprising a serine or threonine proximate to an amino acid capable of binding to a functional group can be used to screen for compounds which prevent or treat cancer. Also disclosed is an antibody or binding portion thereof raised against a binary switch on a histone comprising a phosphorylated serine or threonine proximate to an amino acid bound to a functional group and its use in detecting a condition mediated by that switch.

Abstract: The present invention is directed to a human egg specific protein (ePAD), antibodies specific for the human egg specific protein and the use of the ePAD protein to identify antagonists of ePAD activity. Antagonists of ePAD activity are anticipated to have utility as female contraceptive agents.

Abstract: The present invention relates to the generation of antibodies that bind to specific modifications of the amino terminus of histone H3 and the carboxy terminus of the H2A and H2B peptides. More particularly, the present invention is directed to the generation of a set of antibodies that recognize various post-translational modifications of histone proteins that function as switches for regulating transcription and mitosis. Compositions comprising these antibodies are used as diagnostic and screening tools.

Abstract: The present invention relates to the use of antibodies directed against specific histone amino terminus modifications as diagnostic indicators of disease or congenital defects. In one embodiment, nucleosomes are isolated from a blood or serum sample of a patient using histone specific antibodies and the accompanying DNA is purified and analyzed for diagnostic and screening purposes.

Abstract: A door frame and gusset system for adjustably attaching a strike plate to a door frame. The door frame includes an emboss indentation having slots and tabs. The tabs engage and align a gusset mounted on the back side of the door frame opposite the strike plate. The gusset has threaded holes for engaging screws which attach the strike plate to the gusset through the slots in the emboss indentation. The gusset also has slots which engage the tabs to allow the gusset to move horizontally with respect to the frame and prevent vertical movement of the gusset with respect to the frame. The slots in the emboss indentation allow relative movement of the gusset and strike plate with respect to the door frame to adjust the position of the strike plate. A separate dust box may also be incorporated between the gusset and the door frame. In addition, integral gusset and dust box assembly may be used in connection with the door frame and gusset system.

Abstract: A wind-resistant sectional overhead door (21) selectively moveable between an open position and a closed position relative to a door opening defined by spaced vertical jambs (23,24) and a horizontal header (25) extending therebetween including, a plurality of elongate horizontal panels (40-43) pivotally connected at the top and bottom edges (48, 49) of adjacent of the panels, roller tracks (31, 32) mounted on the vertical jambs to either side of the door, roller shafts (65) mounted at the ends of the panels, guide rollers (66) carried by the roller shafts and engaging the roller tracks, and restraining members (70, 170) for limiting axial movement of the roller shafts, whereby the roller shafts and the panels are tension-loaded when the door is in the closed position to prevent buckling of the panels under applied wind forces. The restraining members may be replaced by or supplemented with tension rod assemblies (225, 325).

Abstract: A wind-resistant sectional overhead door (21) selectively moveable between an open position and a closed position relative to a door opening defined by spaced vertical jambs (23, 24) and a horizontal header (25) extending therebetween including, a plurality of elongate horizontal panels (40-43) pivotally connected at the top and bottom edges (48, 49) of adjacent of the panels, roller tracks (31, 32) mounted on the vertical jambs to either side of the door, roller shafts (65) mounted at the ends of the panels, guide rollers (66) carried by the roller shafts and engaging the roller tracks, and restraining members (70, 170) for limiting axial movement of the roller shafts, whereby the roller shafts and the panels are tension-loaded when the door is in the closed position to prevent buckling of the panels under applied wind forces. The restraining members may be replaced by or supplemented with tension rod assemblies (225, 325).

Abstract: A flexible line trimmer with a vibration dampening support handle includes a rotary power source and a rotatable trimmer head, both of which are connected by a drive shaft enclosed in a rigid housing. A flexible line trimmer has a vibration dampening rear support handle assembly and a front control handle. The rear handle assembly is resiliently coupled to the drive shaft housing and to the power source housing.