Patents by Inventor C.B. Appaiah

C.B. Appaiah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reducing conjugative plasmids in bacteria
    Patent number: 10092608
    Abstract: The present invention provides methods and compositions to reduce prevalence of plasmids in microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions. Means are provided to reduce the copy numbers of antibiotic resistance genes, and to confer phage binding to cells lacking receptors for those phage.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: October 9, 2018
    Assignee: GangaGen, Inc.
    Inventors: C. B. Appaiah, Jayasheela Manur, Bharathi Sriram
  • REDUCING CONJUGATIVE PLASMIDS IN BACTERIA
    Publication number: 20160310549
    Abstract: The present invention provides methods and compositions to reduce prevalence of plasmids in microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions. Means are provided to reduce the copy numbers of antibiotic resistance genes, and to confer phage binding to cells lacking receptors for those phage.
    Type: Application
    Filed: November 23, 2015
    Publication date: October 27, 2016
    Inventors: C.B. Appaiah, Jayasheela Manur, Bharathi Sriram
  • Reducing conjugative plasmids in bacteria
    Patent number: 9193946
    Abstract: The present invention provides methods and compositions to reduce prevalence of plasmids in microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions. Means are provided to reduce the copy numbers of antibiotic resistance genes, and to confer phage binding to cells lacking receptors for those phage.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: November 24, 2015
    Assignee: Gangagen, Inc.
    Inventors: C. B. Appaiah, Jayashella Manur, Bharathi Sriram
  • CHIMERIC ANTIBACTERIAL POLYPEPTIDES
    Publication number: 20140050713
    Abstract: Provided herein are antibacterial compositions and methods of making and using the compositions.
    Type: Application
    Filed: April 12, 2012
    Publication date: February 20, 2014
    Inventors: C.B. Appaiah, Sriram Padmanabhan, R. Sanjeev Saravanan, Bharathi Sriram
  • SOLUBLE CYTOPLASMIC EXPRESSION OF HETEROLOGOUS PROTEINS IN ESCHERICHIA COLI
    Publication number: 20130273585
    Abstract: Soluble variants of recombinant proteins produced in a prokaryotic host cell, where the high expression levels often cause the original proteins to aggregate into insoluble inclusion body aggregates. The variant polypeptides retain biological function while increasing protein solubility with comparable or higher recoverable levels of biologically active protein when expressed in a suitable expression host. Methods of identifying critical residues and substituting them are provided to produce the variants.
    Type: Application
    Filed: April 11, 2013
    Publication date: October 17, 2013
    Applicant: GangaGen, Inc.
    Inventors: C. B. Appaiah, Sriram Padmanabhan, R. Sanjeev Saravanan
  • REDUCING CONJUGATIVE PLASMIDS IN BACTERIA
    Publication number: 20110064699
    Abstract: The present invention provides methods and compositions to reduce prevalence of plasmids in microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions. Means are provided to reduce the copy numbers of antibiotic resistance genes, and to confer phage binding to cells lacking receptors for those phage.
    Type: Application
    Filed: March 10, 2009
    Publication date: March 17, 2011
    Applicant: GangaGen, Inc.
    Inventors: C.B. Appaiah, Jayashella Manur, Bharathi Sriram