Abstract: The disclosure provides anti-Mcl-1 antibodies of any form, and fragments thereof, that bind the antigen with unexpectedly high binding to Mcl-1, providing tools useful in methods of monitoring cancer cells expressing Mcl-1 and methods of treating cancers, particularly blood-borne cancers, comprising such cancer cells.

Abstract: An embodiment includes a system comprising: an outer conduit; a shape memory polymer (SMP) foam; a metal backbone including: (a)(i) a first portion that extends from the SMP foam proximal end to the SMP foam distal end and which is generally covered by the SMP foam, and (a)(ii) a distal portion that extends distally from the SMP foam distal end and which is not covered by the SMP foam; wherein: (b)(i) SMP foam and the metal backbone are both included within the outer conduit adjacent to the outer conduit distal end; (b)(ii) the metal backbone distal portion transitions from a secondary shape that is uncoiled to a primary shape that is coiled; and (b)(iii) the metal backbone distal portion is in the metal backbone distal portion secondary shape and is located between the SMP foam distal end and the distal end of the outer conduit.

Abstract: Stabilized cutting tool assemblies. A cutting tool assembly for use with a reference surface includes a tool holder having a rotational axis. The tool holder is arranged for attachment to a drive source arranged to rotate the tool holder and move the tool holder relative to a reference surface. The cutting tool assembly includes a rotatable cutting tool coupled to the tool holder. The cutting tool includes a cutting surface and has a first portion and a second portion. The first portion is disposed adjacent the tool holder. The cutting tool assembly includes a stabilizer coupled to the cutting tool adjacent the second portion. The stabilizer has a bearing surface. The bearing surface is positioned on the second portion to abut the reference surface and to stabilize the cutting tool when the drive source moves the tool holder and the cutting tool to a position adjacent the reference surface.

Abstract: A foot support assembly for an exercise machine may be configured for sing-hand operation (e.g., cinching or releasing of the foot strap). The foot support assembly may include a footplate coupled to the frame of the exercise machine and configured to support the user's foot during exercise and a strap coupled to the footplate and configured to resist separation of the user's foot from the footplate. The strap is operatively associated with a quick release ratchet mechanism, which is configured to be unlocked simply by pressing a lever of the ratchet to allow the ratchet strip to reverse, releasing the user's foot from the strap. The foot support assembly may be provided on each side of the seat rail of a rowing machine, which may alternatively or additionally include a multi-grip handle including a plurality of grip portions configured to position the user's hand at different orientations to one another.

Abstract: A foot support assembly for an exercise machine may be configured for sing-hand operation (e.g., cinching or releasing of the foot strap), The foot support assembly may include a footplate coupled to the frame of the exercise machine and configured to support the user's foot during exercise and a strap coupled to the footplate and configured to resist separation of the user's foot from the footplate. The strap is operatively associated with a quick release ratchet mechanism, which is configured to be unlocked simply by pressing a lever of the ratchet to allow the ratchet strip to reverse, releasing the user's foot from the strap. The foot support assembly may be provided on each side of the seat rail of a rowing machine, which may alternatively or additionally include a multi-grip handle including a plurality of grip portions configured to position the user's hand at different orientations to one another.

Abstract: A foot support assembly for an exercise machine may be configured for sing-hand operation (e.g., cinching or releasing of the foot strap). The foot support assembly may include a footplate coupled to the frame of the exercise machine and configured to support the user's foot during exercise and a strap coupled to the footplate and configured to resist separation of the user's foot from the footplate. The strap is operatively associated with a quick release ratchet mechanism, which is configured to be unlocked simply by pressing a lever of the ratchet to allow the ratchet strip to reverse, releasing the user's foot from the strap. The foot support assembly may be provided on each side of the seat rail of a rowing machine, which may alternatively or additionally include a multi-grip handle including a plurality of grip portions configured to position the user's hand at different orientations to one another.

Abstract: A rotor blade disassembly method includes applying spanwise support to a rotor blade body and heating a bond disposed on an end of the rotor blade body. The method also includes removing the spanwise support from the rotor blade body and exerting shear stress on the bond using weight of the rotor blade body. A blade disassembly system is also described.

Abstract: A method and system for securely storing and accessing sensitive user data (e.g., personally identifying information or PII) is described. In an aspect, PII is divided into a plurality of separately stored data stores based on what type or field of PII are collected. Each piece of PII data or PII datum is associated with a unique code so as to form data pairs comprising the PII datum and the unique code associated with that PII datum. A tumbler data structure allows secure association of the unique codes for the PII data for each user. Once the tumbler data structure is unlocked, a provider can search and access the PII data of its users.

Abstract: A computer-implemented method includes: generating, by a computing device, a sample of a query, wherein the query maps to a predetermined categorization; processing the sample with a first natural language process, wherein the processing produces an output comprising a categorization of the sample; storing data regarding whether the categorization of the output matches the predetermined categorization; generating a report based on the stored data indicating a percentage of a plurality of samples of the query whose categorizations match the predetermined characterization; outputting the report; and receiving a second natural language process comprising updates to the first natural language process based on the report, wherein the updates increase the percentage of the plurality of samples that match the predetermined categorization when processed with the second natural language process relative to when the plurality of samples was processed with the first natural language process.

Abstract: A foot support assembly for an exercise machine may be configured for sing-hand operation (e.g., cinching or releasing of the foot strap). The foot support assembly may include a footplate coupled to the frame of the exercise machine and configured to support the user's foot during exercise and a strap coupled to the footplate and configured to resist separation of the user's foot from the footplate. The strap is operatively associated with a quick release ratchet mechanism, which is configured to be unlocked simply by pressing a lever of the ratchet to allow the ratchet strip to reverse, releasing the user's foot from the strap. The foot support assembly may be provided on each side of the seat rail of a rowing machine, which may alternatively or additionally include a multi-grip handle including a plurality of grip portions configured to position the user's hand at different orientations to one another.

Abstract: Provided herein are embodiments related to metered dose inhalers and formulations for such inhalers. In some embodiments, the inhalers are configured so as to allow a more comfortable experience for the subject receiving the formulation. In some embodiments, the formulation comprises various ingredients, such as terpenes and/or waxes, which can further enhance the level of comfort for the subject receiving the formulation.

Abstract: Provided herein are embodiments related to metered dose inhalers and formulations for such inhalers. In some embodiments, the inhalers are configured so as to allow a more comfortable experience for the subject receiving the formulation. In some embodiments, the formulation comprises various ingredients, such as terpenes and/or waxes, which can further enhance the level of comfort for the subject receiving the formulation.

Abstract: A method of making a rotor blade assembly includes receiving a sheath assembly and a blade body at a blade assembly tool. The sheath assembly is spread by applying force to an interior surface of the sheath assembly. The blade body is inserted within the interior of the sheath assembly, registered with the sheath assembly, and the force removed from the interior surface of the sheath assembly such that the sheath assembly collapses on the blade body.

Abstract: A computer-implemented method includes: generating, by a computing device, a sample of a query, wherein the query maps to a predetermined categorization; processing the sample with a first natural language process, wherein the processing produces an output comprising a categorization of the sample; storing data regarding whether the categorization of the output matches the predetermined categorization; generating a report based on the stored data indicating a percentage of a plurality of samples of the query whose categorizations match the predetermined characterization; outputting the report; and receiving a second natural language process comprising updates to the first natural language process based on the report, wherein the updates increase the percentage of the plurality of samples that match the predetermined categorization when processed with the second natural language process relative to when the plurality of samples was processed with the first natural language process.

Abstract: A rotor blade disassembly method includes applying spanwise support to a rotor blade body and heating a bond disposed on an end of the rotor blade body. The method also includes removing the spanwise support from the rotor blade body and exerting shear stress on the bond using weight of the rotor blade body. A blade disassembly system is also described.

Abstract: An exercise device having (-) a frame, (-) left and right leg linkages, each including (i) an upper leg member pivotally coupled to the frame for pivoting about an upper pivot point with the upper pivot point of each leg linkage defining a point on a laterally extending upper pivot axis that passes through the upper pivot point of each leg linkage, and (ii) a lower leg member directly pivotally coupled to the upper leg member distal to the upper pivot point for pivoting about a lower pivot point, and (-) a foot support attached to each lower leg member distal to each respective lower pivot point. The invention characterized by an ergonomically synergistic spatial orientation and relationship amongst and between the upper leg members, lower leg members, upper pivot axis, lower pivot axis, hip region of a user, knees of a user, a biased damping means in communication with the lower leg members, and an interconnect member interconnecting the lower leg links with and the biased damping means.

Abstract: A rotor blade disassembly method includes applying spanwise support to a rotor blade body and heating a bond disposed on an end of the rotor blade body. The method also includes removing the spanwise support from the rotor blade body and exerting shear stress on the bond using weight of the rotor blade body. A blade disassembly system is also described.

Abstract: A method for providing information to a user in response to a received user query. A natural language analysis generates substrings relevant to an input user query pertaining to a problem a user experiences with a product or service. An ontology analysis outputs: terms of an ontology matching the relevant generated substrings; and relationships between the terms. Elements of a perfect or complete query are captured and include information pertaining to the user's problem. The input user query is refined based on the outputted terms and relationships between the terms. A search query is performed, based on the refined user query. The results of the search are provided to the user.

Abstract: A method for providing information to a user in response to a received user query. A natural language analysis generates substrings relevant to an input user query pertaining to a problem a user experiences with a product or service. An ontology analysis outputs: terms ontology matching the relevant generated substrings; and relationships between the terms. Elements of a perfect or complete query are captured and include information pertaining to the user's problem. The input user query is refined based on the outputted terms and relationships between the terms. A search query is performed, based on the refined user query. The results of the search are provided to the user.

Abstract: A method of making a rotor blade assembly includes receiving a sheath assembly and a blade body at a blade assembly tool. The sheath assembly is spread by applying force to an interior surface of the sheath assembly. The blade body is inserted within the interior of the sheath assembly, registered with the sheath assembly, and the force removed from the interior surface of the sheath assembly such that the sheath assembly collapses on the blade body.