Abstract: The present invention relates to the treatment of secretory disorders, and provides novel methods of treatment of these disorders comprising the administration of fibroblast growth factor 21 (FGF21) or derivatives thereof. The methods of the invention are useful in conditions including exocrine pancreatic insufficiency (EPI), for example EPI resulting from cystic fibrosis, alcoholism, pancreatitis, pancreatic cancer, gallstones, celiac disease, high triglycerides, or lupus. The methods of the present invention find further utility in the treatment of salivary flow disorders, for example Sjorgen's syndrome, and the treatment of EPI or pancreatitis resulting from surgical procedures.

Abstract: An electrical submersible pump assembly (ESP) has a centrifugal production pump with production pump stages. A gas separator upstream is from the production pump. A centrifugal charge pump is upstream from the gas separator. The charge pump has charge pump stages and a discharge that leads to an intake of the gas separator. Each of the production pump stages has a higher lifting capacity than each of the charge pump stages. The impellers of the production pump stages have vane exit angles greater than vane exit angles of the impellers of the charge pump stages.

Abstract: The present invention relates to the treatment of secretory disorders, and provides novel methods of treatment of these disorders comprising the administration of fibroblast growth factor 21 (FGF21) or derivatives thereof. The methods of the invention are useful in conditions including exocrine pancreatic insufficiency (EPI), for example EPI resulting from cystic fibrosis, alcoholism, pancreatitis, pancreatic cancer, gallstones, celiac disease, high triglycerides, or lupus. The methods of the present invention find further utility in the treatment of salivary flow disorders, for example Sjorgen's syndrome, and the prevention of EPI or pancreatitis resulting from surgical procedures.

Abstract: The present invention relates to the treatment of secretory disorders, and provides novel methods of treatment of these disorders comprising the administration of fibroblast growth factor 21 (FGF21) or derivatives thereof. The methods of the invention are useful in conditions including exocrine pancreatic insufficiency (EPI), for example EPI resulting from cystic fibrosis, alcoholism, pancreatitis, pancreatic cancer, gallstones, celiac disease, high triglycerides, or lupus. The methods of the present invention find further utility in the treatment of salivary flow disorders, for example Sjorgen's syndrome, and the treatment of EPI or pancreatitis resulting from surgical procedures.

Abstract: An apparatus includes a cache controller circuit and a multi-ported cache memory including a plurality of cache ways. The cache controller circuit is configured to maintain rank values and a threshold value usable to classify the rank values. A given rank value corresponds to a least recently used one of the plurality of cache ways. The cache controller circuit is further configured to receive, in a common access cycle, first and second memory access requests for the cache memory, and, in response to a determination that the first and second memory access requests correspond to respective first and a second cache ways, compare the corresponding rank values for the first and second cache ways to the threshold value. The cache controller circuit is further configured to, based on the comparison, modify the rank value of a selected one of the first and second cache ways.

Abstract: An electrical submersible pump assembly (ESP) has a centrifugal production pump with production pump stages. A gas separator upstream is from the production pump. A centrifugal charge pump is upstream from the gas separator. The charge pump has charge pump stages and a discharge that leads to an intake of the gas separator. Each of the production pump stages has a higher lifting capacity than each of the charge pump stages. The impellers of the production pump stages have vane exit angles greater than vane exit angles of the impellers of the charge pump stages.

Abstract: An apparatus includes a cache controller circuit and a multi-ported cache memory including a plurality of cache ways. The cache controller circuit is configured to maintain rank values and a threshold value usable to classify the rank values. A given rank value corresponds to a least recently used one of the plurality of cache ways. The cache controller circuit is further configured to receive, in a common access cycle, first and second memory access requests for the cache memory, and, in response to a determination that the first and second memory access requests correspond to respective first and a second cache ways, compare the corresponding rank values for the first and second cache ways to the threshold value. The cache controller circuit is further configured to, based on the comparison, modify the rank value of a selected one of the first and second cache ways.

Abstract: The present invention provides an article or an interface having a distribution of a first partially spherical indentation and at least a second partially spherical indentation contained within the first indentation to form a multi-component or “compound” shape that is referred to as a “compound” or “nested” dimples or indentations. These compound dimples or indentions may be concentric and are etched or otherwise formed into a surface or interface of an article to enhance the ultrasonic imaging. Exemplary articles may be needles of the type used to conduct nerve blocks or the interface may be the surface of such a needle, cannula, catheter, catheter tip or similar article.

Abstract: The present invention provides an article or an interface having a distribution of a first partially spherical indentation and at least a second partially spherical indentation contained within the first indentation to form a multi-component or “compound” shape that is referred to as a “compound” or “nested” dimples or indentations. These compound dimples or indentions may be concentric and are etched or otherwise formed into a surface or interface of an article to enhance the ultrasonic imaging. Exemplary articles may be needles of the type used to conduct nerve blocks or the interface may be the surface of such a needle, cannula, catheter, catheter tip or similar article.

Abstract: The present invention provides an article or an interface having a distribution of a first partially spherical indentation and at least a second partially spherical indentation contained within the first indentation to form a multi-component or “compound” shape that is referred to as a “compound” or “nested” dimples or indentations. These compound dimples or indentions may be concentric and are etched or otherwise formed into a surface or interface of an article to enhance the ultrasonic imaging. Exemplary articles may be needles of the type used to conduct nerve blocks or the interface may be the surface of such a needle, cannula, catheter, catheter tip or similar article.

Abstract: The present invention provides an article or an interface having a distribution of a first partially spherical indentation and at least a second partially spherical indentation contained within the first indentation to form a multi-component or “compound” shape that is referred to as a “compound” or “nested” dimples or indentations. These compound dimples or indentions may be concentric and are etched or otherwise formed into a surface or interface of an article to enhance the ultrasonic imaging. Exemplary articles may be needles of the type used to conduct nerve blocks or the interface may be the surface of such a needle, cannula, catheter, catheter tip or similar article.

Abstract: The present invention includes compositions and methods for increasing the absorption of nutrients by plants to increase their growth comprising: identifying a plant in need of enhanced nutrient uptake and growth when compared to non-treated plants; obtaining a whole leaf aloe vera extract and at least one plant nutrient selected from nitrogen (N), phosphorous (P), or potassium (K); and mixing the whole leaf aloe vera extract into a plant growth media, wherein the plant absorbs the one or more plant nutrients at a higher rate and the plants have at least one of increased growth, increased grain size, increased grain yield, increased panicles, or an increase in the number of seedlings per plant when compared to the addition of the one or more nutrients alone.

Abstract: The present invention provides an article or an interface having a distribution of a first partially spherical indentation and at least a second partially spherical indentation contained within the first indentation to form a multi-component or “compound” shape that is referred to as a “compound” or “nested” dimples or indentations. These compound dimples or indentions may be concentric and are etched or otherwise formed into a surface or interface of an article to enhance the ultrasonic imaging. Exemplary articles may be needles of the type used to conduct nerve blocks or the interface may be the surface of such a needle, cannula, catheter, catheter tip or similar article.

Abstract: An echogenic nerve block catheter and an echogenic catheter tip member include an echogenic tip member having a plurality of ridges on a first portion of the tip member and a retainer member is on a second portion of the tip member, and the second portion of the tip member is received within the lumen of the nerve block catheter.

Abstract: The present invention includes compositions and methods for the treatment of plants against pathogens, elimination of insects and to increase the shelf-life of fruits and vegetables that includes coating the plant with undiluted aloe vera gel.

Abstract: The present invention includes compositions and methods for the treatment of plants against pathogens, elimination of insects and to increase the shelf-life of fruits and vegetables that includes coating the plant with undiluted aloe vera gel.

Abstract: The present invention includes compositions and methods for treating one or more pathogens that affect plants comprising: identifying a plant or seed in need of treatment of a plant; obtaining a whole leaf aloe vera extract and adding aloin, wherein the aloe vera leaf is processed to eliminate solids and to preserve the gel of the aloe vera gel; and at least one of diluting the whole leaf aloe vera extract and spraying the whole leaf aloe vera extract on the plant or seed, wherein the aloe vera gel and aloin at least one of stop the growth of, reduce the spread of, or kill the one or more pathogens on the plant or reduce the amount of infected plants that arises from the treatment of seeds.

Abstract: The present invention includes compositions and methods for the treatment of plants against pathogens, elimination of insects and to increase the shelf-life of fruits and vegetables that includes coating the plant with undiluted aloe vera gel.

Abstract: The present invention includes compositions and methods for the treatment of plants against pathogens, elimination of insects and to increase the shelf-life of fruits and vegetables that includes coating the plant with undiluted aloe vera gel.

Abstract: The present invention includes compositions and methods for increasing the absorption of nutrients by plants to increase their growth comprising: identifying a plant in need of enhanced nutrient uptake and growth when compared to non-treated plants; obtaining a whole leaf aloe vera extract and at least one plant nutrient selected from nitrogen (N), phosphorous (P), or potassium (K); and mixing the whole leaf aloe vera extract into a plant growth media, wherein the plant absorbs the one or more plant nutrients at a higher rate and the plants have at least one of increased growth, increased grain size, increased grain yield, increased panicles, or an increase in the number of seedlings per plant when compared to the addition of the one or more nutrients alone.