Patents by Inventor Cédric Boisart

Cédric Boisart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200277592
    Abstract: The invention concerns a genetically modified microorganism expressing a functional type I or II RuBisCO enzyme and a functional phosphoribulokinase (PRK), and in which the glycolysis pathway is at least partially inhibited, said microorganism being genetically modified so as to produce an exogenous molecule and/or to overproduce an endogenous molecule. According to the invention, the oxidative branch of the pentose phosphate pathway may also be at least partially inhibited. The invention also concerns the use of such a genetically modified microorganism for the production or overproduction of a molecule of interest and processes for the synthesis or bioconversion of molecules of interest.
    Type: Application
    Filed: January 26, 2018
    Publication date: September 3, 2020
    Inventors: Cedric BOISART, Nicolas MORIN
  • Publication number: 20190359988
    Abstract: The invention concerns a genetically modified microorganism expressing a functional type I or II RuBisCO enzyme and a functional phosphoribulokinase (PRK), and in which the non-oxidative branch of the pentose phosphate pathway is at least partially inhibited, said microorganism being genetically modified so as to produce an exogenous molecule and/or to overproduce an endogenous molecule. The invention also concerns the use of such a genetically modified microorganism for the production or overproduction of a molecule of interest and processes for the synthesis or bioconversion of molecules of interest.
    Type: Application
    Filed: January 26, 2018
    Publication date: November 28, 2019
    Inventors: Cedric BOISART, Nicolas MORIN
  • Patent number: 10124512
    Abstract: The invention relates to a method for recycling at least one plastic product, the method comprising degrading at least one polymer of the plastic product to monomers using an enzyme and recovering the resulting monomers. The method of the invention may be used for degrading, simultaneously or sequentially, at least two different polymers of the plastic product, and/or for recycling at least two plastic products.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: November 13, 2018
    Assignee: CARBIOS
    Inventors: Cédric Boisart, Emmanuel Maille
  • Patent number: 9476073
    Abstract: The invention concerns a microorganism which is genetically modified so as to i) synthesize an organic monomer by fermentation of a carbon source, and ii) depolymerize a polymer constituted at least by an organic monomer which it is capable of synthesizing. The invention also concerns a method for producing an organic monomer using a genetically modified microorganism of this type, as well as the coculture of this microorganism with another microorganism which is capable of synthesizing a polymer of interest.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: October 25, 2016
    Assignee: CARBIOS
    Inventor: Cédric Boisart
  • Publication number: 20160280881
    Abstract: The present invention relates to a method for degrading a plastic containing non-biodegradable polymers comprising submitting said plastic to at least one enzyme for modifying a polymer of said plastic which has a methane potential less than 5 Nm3/t+/?20%, wherein at least one product resulting from the modification exhibits a methane potential greater than 10 Nm3/t+/?20%.
    Type: Application
    Filed: November 4, 2014
    Publication date: September 29, 2016
    Inventors: CÉDRIC BOISART, EMMANUEL MAILLE, FRÉDÉRIQUE GUILLAMOT
  • Patent number: 9410164
    Abstract: The present invention concerns a method for the biological preparation of prenol comprising culturing a microorganism genetically modified for the bioproduction of prenol, wherein the microorganism comprises a metabolic pathway for conversion of 3-methylcrotonyl-CoA into prenol by the action of an alcohol dehydrogenase enzyme and of an aldehyde dehydrogenase enzyme.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: August 9, 2016
    Assignee: METABOLIC EXPLORER
    Inventors: Cedric Boisart, Sr., Guillaume Letellier
  • Patent number: 9382561
    Abstract: The present invention relates to a method for the production of methionine using modified strains with attenuated transformation of threonine. This can be achieved by reducing threonine transformation into glycine, and/or by reducing its transformation to ?-ketobutyrate. The invention also concerns the modified strains with attenuated transformation of threonine.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: July 5, 2016
    Assignee: METABOLIC EXPLORER
    Inventors: Cedric Boisart, Gwenaelle Bestel-Corre, Guillaume Barbier, Rainer Figge
  • Publication number: 20160160249
    Abstract: Process for the production of methionine or its derivatives by culturing a microorganism in an appropriate culture medium comprising a source of carbon and a source of sulfur. The microorganism and/or the culture medium are modified in such way that the methionine/carbon source yield is increased. The isolation of methionine or its derivates from the fermentation medium is also described.
    Type: Application
    Filed: February 12, 2016
    Publication date: June 9, 2016
    Applicant: METABOLIC EXPLORER
    Inventors: Rainer FIGGE, Philippe SOUCAILLE, Guillaume BARBIER, Gwénaëlle BESTEL-CORRE, Cédric BOISART, Michel CHATEAU
  • Publication number: 20150290840
    Abstract: The invention relates to a method for recycling at least one plastic product, the method comprising degrading at least one polymer of the plastic product to monomers using an enzyme and recovering the resulting monomers. The method of the invention may be used for degrading, simultaneously or sequentially at least two different polymers of the plastic product, and/or for recycling at least two plastic products.
    Type: Application
    Filed: November 19, 2013
    Publication date: October 15, 2015
    Inventors: CÉDRIC BOISART, EMMANUEL MAILLE
  • Patent number: 9121041
    Abstract: The present invention concerns a new method for the biological preparation of a diol comprising culturing a microorganism genetically modified for the bioproduction of an aliphatic diol, wherein the microorganism comprises a metabolic pathway for the decarboxylation of a hydroxy-2-keto-aliphatic acid metabolite with an enzyme having a 2-keto acid decarboxylase activity, the product obtained from said decarboxylation step being further reduced into the corresponding aliphatic diol, and wherein the microorganism is genetically modified for the improved production of said hydroxy-2-keto-aliphatic acid metabolite. The invention also concerns a modified microorganism for the production of an aliphatic diol.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: September 1, 2015
    Assignee: METABOLIC EXPLORER
    Inventors: Philippe Soucaille, Cédric Boisart
  • Patent number: 9034611
    Abstract: The present invention is related to a microorganism for the production of methionine, wherein said microorganism is modified to enhance the transhydrogenase activity of PntAB. In a preferred aspect of the invention, the activity of the transhydrogenase UdhA is attenuated in said microorganisms. The invention also related to a method for producing methionine by fermentation.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: May 19, 2015
    Assignee: METALBOLIC EXPLORER
    Inventors: Wanda Dischert, Perrine Vasseur, Cédric Boisart, Rainer Figge
  • Publication number: 20150056673
    Abstract: The invention concerns a microorganism which is genetically modified so as to i) synthesize a hydrocarbon monomer by fermentation of a carbon source, and ii) depolymerize a polymer constituted at least by hydrocarbon monomer which it is capable of synthesizing. The invention also concerns a method for producing a hydrocarbon monomer using a genetically modified microorganism of this type, as well as the coculture of this microorganism with another microorganism which is capable of synthesizing a polymer of interest.
    Type: Application
    Filed: March 27, 2013
    Publication date: February 26, 2015
    Inventor: Cédric Boisart
  • Patent number: 8911978
    Abstract: The present invention concerns a modified microorganism for the biological preparation of an hydroxy acid of formula (I) wherein the microorganism comprises a two-step metabolic pathway for the production of the said hydroxy acid from a hydroxy keto-acid of formula (II) through an intermediate hydroxy-aldehyde of formula (III), wherein EA1 is an enzyme having a 2-keto-acid decarboxylase activity, and EA2 is an enzyme having hydroxy aldehyde dehydrogenase activity. The invention also concerns a method for the fermentative production of a hydroxy acid.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: December 16, 2014
    Assignee: Metabolic Explorer
    Inventors: Philippe Soucaille, Cedric Boisart
  • Patent number: 8900838
    Abstract: A microorganism genetically modified for the bioproduction of 1,3-propanediol from sucrose, wherein the microorganism includes: a two-step metabolic pathway for the production of 1,3-propanediol, including a first step of decarboxylation of 4-hydroxy-2-ketobutyrate with an enzyme having a 2-keto acid decarboxylase activity, and a second step of reduction of the obtained 3-hydroxypropionaldehyde with an enzyme having hydroxy aldehyde reductase activity, and genes enabling the microorganism to utilize sucrose as sole carbon source. A method for the biological preparation of 1,3-propanediol by fermentation, including cultivating said microorganism genetically modified, wherein the culture is performed in an appropriate medium including a source of sucrose, and recovering the 1,3-propanediol being produced.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: December 2, 2014
    Assignee: Metabolic Exployer
    Inventors: Philippe Soucaille, Cedric Boisart
  • Publication number: 20140256008
    Abstract: The present invention concerns a method for the biological preparation of prenol comprising culturing a microorganism genetically modified for the bioproduction of prenol, wherein the microorganism comprises a metabolic pathway for conversion of 3-methylcrotonyl-CoA into prenol by the action of an alcool dehydrogenase enzyme and of an aldehyde dehydrogenase enzyme.
    Type: Application
    Filed: October 11, 2011
    Publication date: September 11, 2014
    Applicant: METABOLIC EXPLORER
    Inventors: Cedric Boisart, SR., Guillaume Letellier
  • Publication number: 20130309737
    Abstract: The present invention concerns a microorganism genetically modified for the bioproduction of 1,3-propanediol from sucrose, wherein the microorganism comprises: a two-step metabolic pathway for the production of 1,3-propanediol, comprising a first step of decarboxylation of 4-hydroxy-2-ketobutyrate with an enzyme having a 2-keto acid decarboxylase activity, and a second step of reduction of the obtained 3 -hydroxypropionaldehyde with an enzyme having hydroxy aldehyde reductase activity, and genes enabling the microorganism to utilize sucrose as sole carbon source. The invention also concerns a new method for the biological preparation of 1,3-propanediol by fermentation, comprising cultivating said microorganism genetically modified, wherein the culture is performed in an appropriate medium comprising a source of sucrose, and recovering the 1,3 -propanediol being produced. In a preferred aspect of the invention, the source of sucrose is obtained from plant biomass.
    Type: Application
    Filed: July 5, 2011
    Publication date: November 21, 2013
    Applicant: METABOLIC EXPLORER
    Inventors: Philippe Soucaille, Cedric Boisart
  • Publication number: 20130183727
    Abstract: The present invention is related to a microorganism for the production of methionine, wherein said microorganism is modified to enhance the transhydrogenase activity of PntAB. In a preferred aspect of the invention, the activity of the transhydrogenase UdhA is attenuated in said microorganisms. The invention also related to a method for producing methionine by fermentation.
    Type: Application
    Filed: October 24, 2011
    Publication date: July 18, 2013
    Applicant: METABOLIC EXPLORER
    Inventors: Wanda Dischert, Perrine Vasseur, Cedric Boisart, Rainer Figge
  • Publication number: 20130109067
    Abstract: The present invention concerns a modified microorganism for the biological preparation of an hydroxy acid of formula (I) wherein the microorganism comprises a two-step metabolic pathway for the production of the said hydroxy acid from a hydroxy keto-acid of formula (II) through an intermediate hydroxy-aldehyde of formula (III), wherein EA1 is an enzyme having a 2-keto-acid decarboxylase activity, and EA2 is an enzyme having hydroxy aldehyde dehydrogenase activity. The invention also concerns a method for the fermentative production of a hydroxy acid.
    Type: Application
    Filed: June 28, 2011
    Publication date: May 2, 2013
    Applicant: METABOLIC EXPLORER
    Inventors: Philippe Soucaille, Cedric Boisart
  • Publication number: 20120288904
    Abstract: The present invention relates to a method for the production of methionine using modified strains with attenuated transformation of threonine. This can be achieved by reducing threonine transformation into glycine, and/or by reducing its transformation to ?-ketobutyrate. The invention also concerns the modified strains with attenuated transformation of threonine.
    Type: Application
    Filed: December 29, 2010
    Publication date: November 15, 2012
    Applicant: METABOLIC EXPLORER
    Inventors: Cedric Boisart, Gwenaelle Bestel-Corre, Guillaume Barbier, Rainer Figge
  • Patent number: 8088620
    Abstract: The invention relates to optimised micro-organism strains for the biotransformation production of molecules having NADPH-consuming biosynthetic pathways. The inventive strains can be used in NADPH-consuming biotransformation methods. Said strains are characterized in that one or more NADPH-oxidizing activities are limited.
    Type: Grant
    Filed: November 5, 2004
    Date of Patent: January 3, 2012
    Assignee: Metabolic Explorer
    Inventors: Gwénaëlle Bestel-Corre, Cédric Boisart, Michel Chateau, Benjamin Gonzalez, Philippe Soucaille, Rainer Figge, Olivier Zink