Patents by Inventor Cédric DRAY

Cédric DRAY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF SHP2 INHIBITORS FOR THE TREATMENT OF INSULIN RESISTANCE
    Publication number: 20250090529
    Abstract: Despite reaching an epidemic status worldwide, metabolic disorders, notably diabetes, still miss efficient and specific therapeutic strategies because of their multifactorial origin. SHP2 is a ubiquitous tyrosine phosphatase that regulates major signalling pathways (e.g. MAPK, PI3K) in response to many growth factors. The inventors evaluate whether chronic inhibition of SHP2 could improve insulin sensitivity in animal models. Obese diabetic mice were thus treated by gavage (50 mg/kg/day). And the inventors note a significant improvement in the glucose tolerance of the treated animals compared to their control, with a decreased fasting blood glucose, without any change in weight or body composition. Accordingly, the present invention relates to use of SHP2 inhibitors for the treatment of insulin resistance.
    Type: Application
    Filed: August 20, 2024
    Publication date: March 20, 2025
    Inventors: Armelle YART, Romain PACCOUD, Mylène TAJAN, Jean-Philippe PRADERE, Philippe VALET, Cédric DRAY
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF POST-OPERATIVE COGNITIVE DYSFUNCTION
    Publication number: 20240226238
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction. In particular, the present invention relates to a method of treating post-operative cognitive dysfunction in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an APJ receptor agonist.
    Type: Application
    Filed: December 27, 2023
    Publication date: July 11, 2024
    Inventors: Philippe VALET, Cedric Dray, Vincent Minville, Bernard Frances, Francois Labaste, Claire Vinel
  • Methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction
    Patent number: 11896649
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction. In particular, the present invention relates to a method of treating post-operative cognitive dysfunction in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an APJ receptor agonist.
    Type: Grant
    Filed: September 27, 2022
    Date of Patent: February 13, 2024
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
    Inventors: Philippe Valet, Cedric Dray, Vincent Minville, Bernard Frances, Francois Labaste, Claire Vinel
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF POST-OPERATIVE COGNITIVE DYSFUNCTION
    Publication number: 20230093887
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction. In particular, the present invention relates to a method of treating post-operative cognitive dysfunction in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an APJ receptor agonist.
    Type: Application
    Filed: September 27, 2022
    Publication date: March 30, 2023
    Inventors: Philippe VALET, Cedric DRAY, Vincent MINVILLE, Bernard FRANCES, Francois LABASTE, Claire VINEL
  • Methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction
    Patent number: 11484577
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction. In particular, the present invention relates to a method of treating post-operative cognitive dysfunction in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an APJ receptor agonist.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: November 1, 2022
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
    Inventors: Philippe Valet, Cedric Dray, Vincent Minville, Bernard Frances, Francois Labaste, Claire Vinel
  • USE OF SHP2 INHIBITORS FOR THE TREATMENT OF INSULIN RESISTANCE
    Publication number: 20220000869
    Abstract: Despite reaching an epidemic status worldwide, metabolic disorders, notably diabetes, still miss efficient and specific therapeutic strategies because of their multifactorial origin. SHP2 is a ubiquitous tyrosine phosphatase that regulates major signalling pathways (e.g. MAPK, PI3K) in response to many growth factors. The inventors evaluate whether chronic inhibition of SHP2 could improve insulin sensitivity in animal models. Obese diabetic mice were thus treated by gavage (50 mg/kg/day). And the inventors note a significant improvement in the glucose tolerance of the treated animals compared to their control, with a decreased fasting blood glucose, without any change in weight or body composition. Accordingly, the present invention relates to use of SHP2 inhibitors for the treatment of insulin resistance.
    Type: Application
    Filed: November 22, 2019
    Publication date: January 6, 2022
    Inventors: Armelle YART, Romain PACCOUD, Mylène TAJAN, Jean-Philippe PRADERE, Philippe VALET, Cédric DRAY
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF POST-OPERATIVE COGNITIVE DYSFUNCTION
    Publication number: 20210196798
    Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction. In particular, the present invention relates to a method of treating post-operative cognitive dysfunction in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an APJ receptor agonist.
    Type: Application
    Filed: February 14, 2017
    Publication date: July 1, 2021
    Inventors: Philippe VALET, Cedric DRAY, Vincent MINVILLE, Bernard FRANCES, Francois LABASTE, Claire VINEL
  • Pharmaceutical composition for use in the treatment of dysfunction associated with aging
    Patent number: 9381229
    Abstract: The present invention relates to an APJ receptor agonist or an apelinomimetic for use in the treatment or the prevention of a dysfunction associated with aging.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: July 5, 2016
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PAUL SABATIER TOULOUSE III
    Inventors: Philippe Valet, Cedric Dray, Claude Knauf, Oksana Kunduzova, Isabelle Castan-Laurell
  • PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF DYSFUNCTION ASSOCIATED WITH AGING
    Publication number: 20150290286
    Abstract: The present invention relates to an APJ receptor agonist or an apelinomimetic for use in the treatment or the prevention of a dysfunction associated with aging.
    Type: Application
    Filed: November 27, 2012
    Publication date: October 15, 2015
    Inventors: Philippe VALET, Cedric DRAY, Claude KNAUF, Oksana KUNDUZOVA, Isabelle CASTAN-LAURELL