Abstract: The invention relates to a method for separating a mixture in an installation comprising a first system comprising a plurality of chromatography columns, a second system downstream of the first system and a tank fed by an outlet line of the first system and feeding the second system with a continuous stream, the method successively comprising, in a cyclical manner, in a given part of the first system, steps of collecting a raffinate, injecting the mixture to be separated, collecting an extract and injecting a mobile phase; wherein the method further comprises the measurement of the purity and/or yield of at least one collected fraction, comprising: the determination of the concentration of at least two species of the mixture to be separated in the fraction collected in the tank; and the determination of the purity and/or yield of at least one species of the fraction collected in the tank.

Abstract: The invention relates to a method for purifying a mixture to be separated, in a multicolumn chromatography system, the method comprising successively and cyclically: a step of collecting a raffinate, a step of injecting the mixture to be separated, a step of collecting an extract and an eluent injection step, at an operating temperature; wherein the mixture to be separated has a viscosity at 20° C. greater than or equal to 3 mPa·s; and wherein the dry matter mass concentration of the mixture to be separated is equal, within 5%, to a threshold concentration, said threshold concentration is such that: the viscosity of the mixture to be treated at a dry matter mass concentration equal to the threshold concentration and at the operating temperature, is equal to twice the viscosity of the mixture to be treated, at a dry matter mass concentration equal to 85% of the threshold concentration and at the operating temperature.

Abstract: The invention relates to a method for separating a mixture in an installation comprising a first system comprising a plurality of chromatography columns, a second system downstream of the first system and a tank fed by an outlet line of the first system and feeding the second system with a continuous stream, the method successively comprising, in a cyclical manner, in a given part of the first system, steps of collecting a raffinate, injecting the mixture to be separated, collecting an extract and injecting a mobile phase; wherein the method further comprises the measurement of the purity and/or yield of at least one collected fraction, comprising: the determination of the concentration of at least two species of the mixture to be separated in the fraction collected in the tank; and the determination of the purity and/or yield of at least one species of the fraction collected in the tank.

Abstract: The invention relates to a method for separating a mixture in a system comprising a plurality of chromatography columns, the method successively comprising, in a cyclical manner, in a given part of the system, steps of collecting a raffinate, injecting the mixture to be separated, collecting an extract and injecting a mobile phase; wherein the method further comprises measuring the purity and/or yield of a collected fraction, comprising: the determination, in a node of the system, of the histories of at least two variables that are representative of the concentration of at least two species contained in the mixture to be separated using at least one fast online detector; the determination of the concentration of at least two species of the mixture to be separated in the collected fraction based on these histories; and the determination of the purity and/or yield of the collected fraction based on these concentrations.

Abstract: The invention relates to a method for separating a mixture in a system comprising a plurality of chromatography columns, the method successively comprising, in a cyclical manner, in a given part of the system: a step of collecting a raffinate; a step of injecting the mixture to be separated; a step of collecting an extract; and a step of injecting a mobile phase; the method further comprising: determining, in a node of the system, the history of a variable representing the concentration of at least one species contained in the mixture to be separated; detecting, within said history, a characteristic point between the beginning of a step of collecting the extract and the end of the following step of collecting the raffinate; comparing the position of the characteristic point in relation to a target position; and adjusting the carrier volume of the characteristic point, modifying the position of the characteristic point in order to bring the position of the characteristic point closer to the target position; th

Abstract: The invention relates to a method for purifying a mixture to be separated, in a multicolumn chromatography system, the method comprising successively and cyclically: a step of collecting a raffinate, a step of injecting the mixture to be separated, a step of collecting an extract and an eluent injection step, at an operating temperature; wherein the mixture to be separated has a viscosity at 20° C. greater than or equal to 3 mPa·s; and wherein the dry matter mass concentration of the mixture to be separated is equal, within 5%, to a threshold concentration, said threshold concentration is such that: the viscosity of the mixture to be treated at a dry matter mass concentration equal to the threshold concentration and at the operating temperature, is equal to twice the viscosity of the mixture to be treated, at a dry matter mass concentration equal to 85% of the threshold concentration and at the operating temperature.

Abstract: The invention relates to a method for separating a mixture in a system comprising a plurality of chromatography columns, the method successively comprising, in a cyclical manner, in a given part of the system: a step of collecting a raffinate; a step of injecting the mixture to be separated; a step of collecting an extract; and a step of injecting a mobile phase; the method further comprising: determining, in a node of the system, the history of a variable representing the concentration of at least one species contained in the mixture to be separated; detecting, within said history, a characteristic point between the beginning of a step of collecting the extract and the end of the following step of collecting the raffinate; comparing the position of the characteristic point in relation to a target position; and adjusting the carrier volume of the characteristic point, modifying the position of the characteristic point in order to bring the position of the characteristic point closer to the target position; th

Abstract: The invention relates to a method for purifying a solution, the method comprising the following successive steps: —bringing a solution to be purified into contact with an ion exchange resin by suspending the ion exchange resin in the solution to be purified, the ion exchange resin having the form of particles having a size Dv50 smaller than or equal to 200 ?m; —separating the solution into a purified solution and a loaded resin; —regenerating the loaded resin by passing at least one regenerating solution through a compact bed of loaded resin. The invention also relates to an assembly for implementing the method.

Abstract: The invention relates to a fluid distributor (9, 10) for a column (1) comprising at least one cell (2) containing a bed of particles (3), the fluid distributor (9, 10) comprising: —a floor (11, 21) comprising at least one injection point (15, 25) providing a fluidic connection on either side thereof; —a layer of a resistive medium (12, 22) fixed on one face of the floor (11, 21), the resistive medium being permeable to the fluid; —a spacing device (13, 23) inserted between the floor (11, 21) and the layer of resistive medium (12, 22) and maintaining a space for the circulation of the fluid between the floor (11, 21) and the layer of resistive medium (12, 22). The invention also relates to a column, in particular a chromatography column, provided with this fluid distributor.

Abstract: The invention relates to a method for purifying a solution, the method comprising the following successive steps: —bringing a solution to be purified into contact with an ion exchange resin by suspending the ion exchange resin in the solution to be purified, the ion exchange resin having the form of particles having a size Dv50 smaller than or equal to 200 ?m; —separating the solution into a purified solution and a loaded resin; —regenerating the loaded resin by passing at least one regenerating solution through a compact bed of loaded resin. The invention also relates to an assembly for implementing the method.

Abstract: The invention relates to a fluid distributor (9,10)for a column (1)comprising at least one cell (2) containing a bed of particles (3), the fluid distributor (9, 10) comprising: - a floor (11, 21) comprising at least one injection point (15, 25) providing a fluidic connection on either side thereof; - a layer of resistive medium (12, 22) fixed on one face of the floor(11, 21), the resistive medium being permeable to the fluid; - a spacing device (13, 23) inserted between the floor (11, 21) and the layer of reistive medium (12, 22) and maintaining a space for the circulation of the fluid between the floor (11, 21) and the layer of resistive medium (12, 22). The invention also relates to a column, in particular a chromatography column, provided with this fluid distributor.

Abstract: A read circuit for an electrical signal produced by a POSFET device is disclosed which comprises a transconductance amplifier (4) connected at its inverting input to the output of the POSFET device (1), at least one neuron (8a, 8b) connected to the output of said transconductance amplifier, said amplifier being adapted to receive a signal from the POSFET device representative of a force or pressure exerted on it and to produce at its output at least one current signal (I0?, I0+) representative of such force or pressure, the at least one neuron being adapted to receive said current signal and to produce an output signal (12a, 12b) being a pulse train with frequency proportional to said current signal.