Abstract: The present disclosure provides methods and kits for evaluating Alzheimer's disease (AD) activity, including in patients undergoing treatment for AD or a candidate treatment for AD, as well as in animal and cell models. Specifically, the present disclosure provides biomarkers (sRNA predictors) that are binary predictors of disease activity, and are useful for detecting and/or evaluating AD disease stage, grade and progression, prognosis, and response to therapy or candidate therapy. The biomarkers are further useful in the context of drug discovery and clinical trials, to identify candidate pharmaceutical interventions (or other therapies) that are useful for the treatment of disease.

Abstract: Boot status markers record historical boot processes performed by a computer system. Each time the computer system boots, an operating system performs a boot process and interfaces with an antimalware driver. The antimalware driver determines the boot status markers that were set during previous boot processes. The antimalware driver may then classify other drivers based on the boot status markers set during the previous boot processes. The antimalware driver may then report driver classifications to the operating system. The operating system may then block, or allow, the drivers based on the driver classifications.

Abstract: Cloud-delivered hooks are injected as binary instrumentation into a software application. The cloud-delivered hooks are specified by a cloud computing environment. The cloud-delivered hooks may be set up, and torn down, by software updates from the cloud computing environment. The cloud-delivered hooks monitor and intercept functions, APIs, and system calls in both user space and kernel space. Moreover, the cloud-delivered hooks may utilize a polymorphic universal hooking mechanism that eliminates strict signature requirements between target functions and detour functions. Because the cloud-delivered hooks are commanded by, and received from, the cloud computing environment, the cloud-delivered hooks may be easily and nearly instantaneously distributed to clients in the field for near real time software instrumentation and reporting. The cloud-delivered hooks can thus greatly simplify and quicken software development, software debugging, malware detection, and software monitoring.

Abstract: The invention describes a method to synthesize a divinyl- and diepoxy-substituted dibenzocyclooctanes, thereby providing a curative that can undergo a twist-boat to chair isomerization at elevated temperatures. The synthetic approach can be applied to a variety of thermosetting resins that can be crosslinked with the curative to form a polymer having a tunable coefficient of thermal expansion.

Abstract: A battery cell unit comprising a battery cell body, and outgassing material encapsulating the battery cell body, wherein (i) the outgassing material comprises a compound that emits one or more off-gasses at a range of off-gas temperatures, (ii) the range of off-gas temperatures is associated with a thermal runaway pending event, and (iii) the one or more off-gasses are detectable by a gas sensor.

Abstract: Methods and apparatuses associated with flow sensing devices are provided. An example flow sensing device includes a flow cap component and a sensor component. The flow cap component or sensor component may include a heating element. The flow cap component can at least partially define a flow channel configured for a media to flow therethrough. The heater element may be orthogonal or perpendicular to the flow channel. The sensor component may include at least one thermal sensing element disposed upstream of the heater element and at least one thermal sensing element disposed downstream of the heater element. The sensor component may include two or more thermal sensing elements disposed in either the upstream direction or downstream direction of the heater element. Thermal sensing elements may be spaced different distances from the heater element to increase the accuracy and precision of flow rate measurement at low flow rates.

Abstract: Described herein are variant adeno-associated virus (AAV) capsid polypeptides and gene therapeutics thereof for use in the treatment or prevention of hearing loss.

Abstract: A breakaway mitigation system is provided for addressing breakaway between a tractor and a trailer unit of a truck. The breakaway mitigation system can include a spool assembly, a sensor, and a controller. The spool assembly has a spool body configured to deploy a length of a tether coupled with the spool body and configured to couple with an energy source supply conduit and to retract the length of the tether. The energy source supply conduit is configured to convey a source of energy for use by a motor or by a fuel cell. The sensor is configured to detect the length of the tether that has been deployed. The controller is configured to receive an input corresponding to the detected length and to implement a countermeasure when the detected amount exceeds a threshold value. Mitigation can be provided by a coupler that decouples under a load over a threshold.

Abstract: Described herein are variant adeno-associated virus (AAV) capsid polypeptides and gene therapeutics thereof for use in the treatment or prevention of hearing loss.

Abstract: This invention provides for a fusion protein between a single chain TNFR2 Selective Agonist protein (scTNFR2 Selective Agonist) and a dimerization domain, such as an IgGFc protein. The single chain TNFR2 Selective Agonist moiety provides a therapeutic activity by selectively activating the TNFR2 form of the TNF-? receptor, thus selectively stimulating Tregs and/or increasing myelin deposition.

Abstract: A breakaway mitigation system is provided for addressing breakaway between a tractor and a trailer unit of a truck. The breakaway mitigation system can include a spool assembly, a sensor, and a controller. The spool assembly has a spool body configured to deploy a length of a tether coupled with the spool body and configured to couple with an energy source supply conduit and to retract the length of the tether. The energy source supply conduit is configured to convey a source of energy for use by a motor or by a fuel cell. The sensor is configured to detect the length of the tether that has been deployed. The controller is configured to receive an input corresponding to the detected length and to implement a countermeasure when the detected amount exceeds a threshold value. Mitigation can be provided by a coupler that decouples under a load over a threshold.

Abstract: Methods, apparatuses, and systems associated with aerosol collection devices (such as, but not limited to, breath-aerosol collector devices, breathalyzers) are provided. An example aerosol collection device includes a sample transfer adapter configured to receive a sample and a device body connected to the sample transfer adapter. In some examples, the device body defines a flow channel that guides the sample to a filter component, and the filter component contains a buffer solution.

Abstract: Linear polymers and copolymers having tunable coefficients of thermal expansion can be derived from dibenzocyclooctene-based monomers. The dibenzocyclooctene-based monomer can comprise a dibenzocyclooctene or a heterocyclic derivative of dibenzocyclooctene. For example, the linear polymer can comprise a polymer or copolymer of a dibenzocyclooctene-based moiety and a polyester, polyamide, polyimide, polyurethane, or epoxy.

Abstract: Curatives and their resulting thermosets and other crosslinked polymers can reduce thermal expansion mismatch between an encapsulant and objects that are encapsulated. This can be accomplished by incorporating a negative CTE moiety into the thermoset resin or polymer backbone. The negative CTE moiety can be a thermal contractile unit that shrinks as a result of thermally induced conversion from a twist-boat to chair or cis/trans isomerization upon heating. Beyond CTE matching, other potential uses for these crosslinked polymers and thermosets include passive energy generation, energy absorption at high strain rates, mechanophores, actuators, and piezoelectric applications.

Abstract: Methods, apparatuses, and systems associated with aerosol collection devices (such as, but not limited to, breath-aerosol collector devices, breathalyzers) are provided. An example aerosol collection device includes a sample transfer adapter configured to receive a sample and a device body connected to the sample transfer adapter. In some examples, the device body defines a flow channel that guides the sample to a filter component, and the filter component contains a buffer solution.

Abstract: Methods, apparatuses, and systems associated with aerosol collection devices (such as, but not limited to, breath-aerosol collector devices, breathalyzers) are provided. An example aerosol collection device includes a sample transfer adapter configured to receive a sample and a device body connected to the sample transfer adapter. In some examples, the device body defines a flow channel that guides the sample to a filter component, and the filter component contains a buffer solution.

Abstract: Methods, apparatuses, and systems associated with aerosol collection devices (such as, but not limited to, breath-aerosol collector devices, breathalyzers) are provided. An example aerosol collection device includes a sample transfer adapter configured to receive a sample and a device body connected to the sample transfer adapter. In some examples, the device body defines a flow channel that guides the sample to a filter component, and the filter component contains a buffer solution.

Abstract: Methods, apparatuses, and systems associated with aerosol collection devices (such as, but not limited to, breath-aerosol collector devices, breathalyzers) are provided. An example aerosol collection device includes a sample transfer adapter configured to receive a sample and a device body connected to the sample transfer adapter. In some examples, the device body defines a flow channel that guides the sample to a filter component, and the filter component contains a buffer solution.

Abstract: A breakaway mitigation system is provided for addressing breakaway between a tractor and a trailer unit of a truck. The breakaway mitigation system can include a spool assembly, a sensor, and a controller. The spool assembly has a spool body configured to deploy a length of a tether coupled with the spool body and configured to couple with an energy source supply conduit and to retract the length of the tether. The energy source supply conduit is configured to convey a source of energy for use by a motor or by a fuel cell. The sensor is configured to detect the length of the tether that has been deployed. The controller is configured to receive an input corresponding to the detected length and to implement a countermeasure when the detected amount exceeds a threshold value. Mitigation can be provided by a coupler that decouples under a load over a threshold.

Abstract: Methods and apparatuses associated with an example flow sensing device are provided. In some examples, the flow sensing device may include a flow cap component and a sensor component. In some examples, the flow cap component may include a heating element disposed in a first layer of the flow cap component. In some examples, the sensor component may include at least one thermal sensing element disposed in a second layer of the sensor component. In some examples, the first layer and the second layer are noncoplanar. In some examples, the flow cap component may be bonded to a first surface of the sensor component to form a flow channel. In some examples, the first layer and the second layer may be noncoplanar and separated by the flow channel.