Abstract: A method is disclosed for creating a patient-specific orthopedic implant. The method includes creating a numerical representation of an orthopedic implant design based on patient data describing an anatomical, physiological and pathological condition of a patient and simulating a characteristic of the orthopedic implant design based on the numerical representation. The method further includes selecting a patient-specific orthopedic implant design based on the simulated characteristic of the orthopedic implant design and the patient data and constructing at least one patient-specific orthopedic implant based on the selected patient-specific orthopedic implant design.

Abstract: A method of generating parameters to guide a spreading process of a three dimensional printer may include the following steps: determining one or more properties of an actual powder; generating a virtual powder model which mimics the actual powder; performing one or more virtual spreading simulations; experimentally validating virtual spreading; and using advanced regression techniques to generate spreading process map from a few virtual spreading simulations.

Abstract: Described herein are devices, systems and methods for lysing algae cells, for production of a lysate product such as a biofuel. The systems and methods use a passive device that lyses the cells through flow configurations, geometries, and surfaces that would induce different stresses and negative pressure on the microalgae cells. When the stress is designed to exceed the mechanical strength of the microalgae cells, the cells are lysed, causing, e.g., lipid release which can be used to produce biofuels. Through an internally-created computational framework, the concept is validated and can be optimized for the lowest energy input with the highest level of lipid release. Also provided herein are computer-implemented methods for optimizing lysis in such systems and computer-readable media containing instructions for performing the computer-implemented methods.