Abstract: A set of contiguous and partially overlapping CDNA sequences and polypeptides encoded thereby, designated as BS265 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer.

Abstract: An air-to-air aftercooler or heat exchanger for a vehicular internal combustion engine, which is independent of the main vehicle heat exchanger or radiator, and which is located at a position upon the vehicle which is remote from the main vehicle heat exchanger or radiator, has a filter for filtering ambient air; at least one aftercooler heat exchanger, separate from the main radiator heat exchanger and disposed upon the engine at a location remote from the main radiator heat exchanger, and having a first passageway defined therein which is fluidically connected to the filter for receiving the ambient air which has passed through the filter; a second passageway defined within the at least one aftercooler heat exchanger for receiving turbocharged air from the turbocharger, for conducting the turbocharged air through the at least one aftercooler heat exchanger such that the turbocharged air undergoes a heat exchange process with the ambient air, and for conducting the turbocharged air to the engine intake manif

Abstract: A data communication system is provided which permits of communication between a deployed implantable medical device (IMD) and a computing resource capable of storing and distributing patient and device data. A deployed IMD may be polled by a programmer device external to the host patient, and data may be transmitted to the programmer by wireless communication. This data may be transmitted to a central computer for storage and distribution. The data may be distributed to business system computers affiliated or connected to the central computer, for example. The data may also be distributed to third parties for invoicing inventory, and supply consideration.

Abstract: Novel polymer-supported quenching reagents of Formula (I): P-L-Q, wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

Abstract: Substrates and inhibitors for the cysteine protease Ich-1 are disclosed. These compounds are designed based on an optimal minimal substrate for Ich-1 and include reversible inhibitors, irreversible inhibitors, selectively reversible inhibitors, chromogenic substrates, fluorogenic substrates and radiolabeled substrates/inhibitors. Pharmaceutical compositions comprising the compounds of the invention are also provided. Methods for inhibiting the proteolytic activity of Ich-1, methods for detecting the presence of Ich-1 and methods for isolating Ich-1 using the compounds of the invention are also disclosed.

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS108 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS108-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS108 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

Abstract: Polypeptides and polynucleotides useful for detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary cancer, are described. These sequences are derived from keratin/cytokeratin, CAS, or mat-8 polypeptides and polynucleotides. Also provided are antibodies which specifically bind to keratin/cytokeratin, CAS, or mat-8-encoded polypeptides or proteins, which molecules are useful for the therapeutic treatment of urinary tract diseases, tumors or metastases.

Abstract: A novel member of the uteroglobin family of proteins, designated as BU101, is described. BU101 is defined by a set of contiguous and partially overlapping RNA sequences transcribed from breast tissue, and polypeptides encoded thereby. A fully sequenced clone representing the longest continuous sequence of BU101 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BU101-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BU101 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

Abstract: A process for the attachment of aromatic or heteroaromatic rings to a polymeric support via a silyl ether linkage is described. Such process involves the synthesis of a chlorodialkyl aryl or heteroarylsilane which is then coupled to a polymeric support via a hydroxyl functionality to form a polymer-bound silyl ether. Further modification provides a polymer-bound small organic molecule that is cleaved from the polymeric support under mild conditions to give an aryl or heteroaryl silanol or a compound in which the aryl or heteroaryl carbon-silicon bond is replaced with a carbon-hydrogen, carbon-halogen, carbon-hydroxyl, carbon-sulfur, or carbon—carbon bond. Such methods are useful for the preparation of a library of diverse aromatic and heteroaromatic compounds by both manual and automated synthesis.

Abstract: A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS108 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS108-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS108 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS112 and transcribed from prostate tissue is described. A fully sequenced clone representing a continuous sequence of PS112 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS112-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS112 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

Abstract: A sharpening guide assembly for use in sharpening ski and snowboard edges includes an angle member and at least one riser member. The angle member includes at least a first outer surface and a second outer surface, an inner edge of the first outer surface adjoining an upper edge of the second outer surface. The riser member is positioned on the first outer surface of the angle member such that a top portion of the riser member extends above the first surface of the angle member. The angle member is formed of a first material and the riser member is formed of a second material, wherein the second material has a hardness which is greater than a hardness of the first material. During a sharpening operation, a sharpening tool is supported on the riser member such that the sharpening tool such as a file member is positioned above the first outer surface of the angle member so as to avoid potential wear causing contact therewith.

Abstract: A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as LU103 and transcribed from lung tissue is described. A fully sequenced clone representing the longest continuous sequence of LU103 is also disclosed. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the lung such as lung cancer.

Abstract: A device and methods to measure the wheel alignment, to measure the position and orientation of the wheels in relation to the chassis, to measure the chassis and body and to measure parameters of vehicles for problem diagnosis. A beam of colliminated light is directed along a latitudinal reference line. The angle and distance relationship of the wheels to this line are measured. A light beam perpendicular to the latitudinal reference light beam is directed longitudinal to the vehicle. The latitudinal light beam and the longitudinal light beams form a rectangular grid system from which the position of vehicle chassis parts can be measured. A method to calculate and compensate for the errors in the measurement system is used with gravity sensors to more accurately calculate toe, camber and tilt. These angular relations provide toe relative the chassis, camber, caster, s.a.i. and included angle. Also, offset and setback of the front and rear wheels relative to the chassis are provided.

Abstract: An integrated electric motor-driven in-line hydraulic pump that includes a housing with an internal shaft, and a cylinder block mounted for rotation on the shaft. The rotor of an electric motor has an internally affixed bearing sleeve that is rotatably supported with respect to the shaft surrounding the cylinder block within the housing. Teeth on the sleeve engage splines on the cylinder block for rotatably coupling the rotor to the cylinder block. The stator of the electric motor is affixed within the housing surrounding the rotor. Pistons are operatively coupled to the cylinder block and engage a yoke plate for obtaining positive displacement pumping action upon energization of the motor. Fluid inlet and outlet ports feed hydraulic fluid through the housing to the cylinder block and pistons, and from the cylinder block to the outlet port.

Abstract: A device for particle agglutination analysis and a method for its use. The device includes means forming a longitudinally extending channel, an opening communicating from the exterior of the device to a first end of the channel, a reservoir communicating with the second end of the channel, and a vent opening communicating from the reservoir to the exterior of the apparatus. The channel has a sufficiently large cross section and the vent is positioned such that, when the channel is in a vertical position, a given amount of fluid, introduced through the opening into the channel will flow by gravity through the channel and into the reservoir, filling the channel to a desired height and the reservoir to the same height without flowing through the vent, while air escapes through the vent. Gravity causes sufficient movement of the particles so that agglutination may occur.