Abstract: The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.

Abstract: Streptomyces plasmids comprising a SCP2*-derived vector, lacking a specific 45 base pair sequence, have a higher copy number and can be used to increase gene expression in host cells. Such plasmids, encoding polyketide synthase genes, are useful for polyketide production in host cells.

Abstract: Method and apparatus for detecting unacceptable misalignment of welding electrodes. An electrode-alignment station is positioned adjacent a welding station. A robot controls the movement of the electrodes, and occasionally moves the electrodes out of the welding station and into an electrode-alignment station. At the electrode-alignment station, the electrodes are closed on a fixture that transfers electrode-misalignment into movement of a plate that triggers an alarm if the misalignment is greater than a prescribed amount.

Abstract: Method and apparatus for detecting unacceptable misalignment of welding electrodes. An electrode-alignment station is positioned adjacent a welding station. A robot controls the movement of the electrodes, and occasionally moves the electrodes out of the welding station and into an electrode-alignment station. At the electrode-alignment station, the electrodes are closed on a fixture that transfers electrode-misalignment into movement of a plate that triggers an alarm if the misalignment is greater than a prescribed amount.

Abstract: A method of single sided spot welding includes the steps of providing a metal tube having a convex surface portion and providing a metal sheet for welding to the metal tube. The method also includes the steps of contacting the metal sheet with the convex surface portion of the metal tube and contacting the metal sheet with a welding electrode. The method further includes the steps of supplying power to the welding electrode for melting metal and solidifying the molten metal to form a weld nugget between the metal sheet and the metal tube.

Abstract: A method of single sided, spot welding includes the steps of providing a metal tube having a convex surface portion and providing a metal sheet for welding to the metal tube. The method also includes the steps of contacting the metal sheet with the convex surface portion of the metal tube and contacting the metal sheet with a welding electrode. The method further includes the steps of supplying power to the welding electrode for melting metal and solidifying the molten metal to form a weld nugget between the metal sheet and the metal tube.

Abstract: The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides that encode such enzymes, and to host cells in which such encoding polynucleotides can be advantageously expressed.

Abstract: The present invention is for a method of lap joining two tubular members and then hydroforming the tubular assembly. An insert end of the first tubular member is inserted into a receiver end of the second tubular member to form a lap joint. A filler metal ring is placed about the outer periphery of the insert end so that it is adjacent the opening of the receiver end of the second tubular member. Heat is applied to braze or solder the lap joint, forming a tubular assembly. The tubular assembly is then hydroformed during which time a supplementary mechanical lock may be formed in the lap joint.

Abstract: A ring plethysmograph having a pressure adjustment for locally pressurizing one side of a finger thereby biasing the pressure on an artery wall so that the plethysmograph is optimally sensitive without interfering with blood flow. An auxiliary photodetector, possibly with a second light source, is disposed on the low-pressure side of the finger for two purposes: providing a noise reference for canceling noise on the plethysmograph signal, and also for providing a separate motion signal for monitoring the activity level of a patient.

Abstract: The invention provides techniques for duplicating all or part of a file system while maintaining consistent copies of the file system. A preferred embodiment reads data from the source file system (mapped according to a first storage block arrangement) creates an image stream and writes this data onto the destination file system (in accordance with a second storage block arrangement). Thus, the invention allows an image transfer between file systems that have dissimilar characteristics. An intermediate storage medium can be used to store or transmit the data read from the source file system before writing the data to the destination file system. (For example, the intermediate storage medium can include a magnetic tape or other archival device, or a network.) Another aspect of the invention writes the data to the intermediate storage medium using a normalized or implied block list.

Abstract: The present invention is for a method of lap joining two tubular members and then hydroforming the tubular assembly. An insert end of the first tubular member is inserted into a receiver end of the second tubular member to form a lap joint. A filler metal ring is placed about the outer periphery of the insert end so that it is adjacent the opening of the receiver end of the second tubular member. Heat is applied to braze or solder the lap joint, forming a tubular assembly. The tubular assembly is then hydroformed during which time a supplementary mechanical lock may be formed in the lap joint.

Abstract: The invention provides techniques for duplicating all or part of a file system while maintaining consistent copies of the file system. A preferred embodiment reads data from the source file system (mapped according to a first storage block arrangement) creates an image stream and writes this data onto the destination file system (in accordance with a second storage block arrangement). Thus, the invention allows an image transfer between file systems that have dissimilar characteristics. An intermediate storage medium can be used to store or transmit the data read from the source file system before writing the data to the destination file system. (For example, the intermediate storage medium can include a magnetic tape or other archival device, or a network.) Another aspect of the invention writes the data to the intermediate storage medium using a normalized or implied block list.

Abstract: Streptomyces plasmids comprising two SCP2-derived replicons, at least one of which is derived from SCP2@, have a higher copy number and exhibit greater stability than SCP2- or SCP2*-derived plasmids having only a single SCP2-derived replicon and can be used to increase gene expression, relative to the latter plasmids, in host cells.

Abstract: A ring plethysmograph having a pressure adjustment for locally pressurizing one side of a finger thereby biasing the pressure on an artery wall so that the plethysmograph is optimally sensitive without interfering with blood flow. An auxiliary photodetector, possibly with a second light source, is disposed on the low-pressure side of the finger for two purposes: providing a noise reference for canceling noise on the plethysmograph signal, and also for providing a separate motion signal for monitoring the activity level of a patient.

Abstract: A trimming device carriage system for allowing a user to conveniently utilize a conventional trimming device without requiring significant effort by the user. The inventive device includes a support structure secured to a second base, a pair of handles secured to a first base, and a pair of brackets attached to each of the first base and the second base for removably engaging a trimmer shaft of a conventional trimmer. The support structure comprises a pair of upper legs secured to the second base and slidably positioned within a corresponding pair of lower legs. A plurality of adjustment apertures within the upper legs catchably receive a detent springably attached to the pair of lower legs. The upper legs are pivotally attached to the second base by a pair of second wing fasteners. The pair of handles are pivotally attached to the first base by a pair of first wing fasteners thereby allowing adjustment of the angle of the handles.