Patents by Inventor C. K. Lau

C. K. Lau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11993626
    Abstract: Embodiments of the present application relate to functionalized N-acetylgalactosamine-analogs, methods of making, and uses of the same. In particular, mono or trivalent N-acetylgalactosamine analogs may be prepared by utilizing a wide variety of linkers containing functional groups. These functionalized N-acetylgalactosamine-analogs may be used in the preparation of targeted delivery of oligonucleotide-based therapeutics.
    Type: Grant
    Filed: December 13, 2022
    Date of Patent: May 28, 2024
    Assignee: Hongene Biotech Corporation
    Inventors: Wing C. Poon, Xiaoyang Guan, David Yu, Ruiming Zou, Xiaojun Li, Michael Su, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Aldrich N. K. Lau
  • Publication number: 20240117362
    Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.
    Type: Application
    Filed: August 16, 2023
    Publication date: April 11, 2024
    Inventors: Mufa Zou, David Yu, Aldrich N.K. Lau, Ruiming Zou, Wing C. Poon, Gang Zhao, Gengyu Du, Yun-Chiao Yao, Allen Wong, Xiaojun Li
  • Patent number: 10227575
    Abstract: An isolated chimeric recombinant protein has cutinase activity. The protein includes a cutinase catalytic domain and a polymer binding domain operably linked by a proline/threonine-rich linker domain. The proline/threonine-rich linker domain includes at least 50% proline or threonine residues over a stretch of 15 to 55 consecutive amino acids.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: March 12, 2019
    Assignees: Ozymes, National Research Council of Canada
    Inventors: Kofi Abokitse, Peter C. K. Lau, Stephan Grosse
  • Publication number: 20170335298
    Abstract: An isolated chimeric recombinant protein has cutinase activity. The protein includes a cutinase catalytic domain and a polymer binding domain operably linked by a proline/threonine-rich linker domain. The proline/threonine-rich linker domain includes at least 50% proline or threonine residues over a stretch of 15 to 55 consecutive amino acids.
    Type: Application
    Filed: August 9, 2017
    Publication date: November 23, 2017
    Inventors: Kofi Abokitse, Peter C.K. Lau, Stephan Grosse
  • Patent number: 9752131
    Abstract: Multi-domain recombinant proteins have a cutinase catalytic domain. The cutinase catalytic domain is a modular domain, which may be combined with other protein domains that also function in a modular fashion. For example, the cutinase catalytic domain can be operably linked to a polymer binding domain via a linker domain (e.g., a threonine/proline-rich linker polypeptide). The cutinase catalytic domain can be from an endogenous cutinase having a multi-domain modular organization, such as from the actinobacterium Kineococcus radiotolerans. The recombinant proteins are used in compositions, methods and uses, such as for use in industrial applications.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: September 5, 2017
    Assignees: NATIONAL RESEARCH COUNCIL OF CANADA, OZYMES
    Inventors: Kofi Abokitse, Peter C. K. Lau, Stephan Grosse
  • Publication number: 20160319257
    Abstract: Multi-domain recombinant proteins have a cutinase catalytic domain. The cutinase catalytic domain is a modular domain, which may be combined with other protein domains that also function in a modular fashion. For example, the cutinase catalytic domain can be operably linked to a polymer binding domain via a linker domain (e.g., a threonine/proline-rich linker polypeptide). The cutinase catalytic domain can be from an endogenous cutinase having a multi-domain modular organization, such as from the actinobacterium Kineococcus radiotolerans. The recombinant proteins are used in compositions, methods and uses, such as for use in industrial applications.
    Type: Application
    Filed: February 16, 2016
    Publication date: November 3, 2016
    Inventors: Kofi Abokitse, Peter C.K. Lau, Stephan Grosse
  • Patent number: 8163894
    Abstract: The invention relates to a new “gene-switch” (cumate-inducible switch) for mammalian cells, having a mammalian promoter which has a TATA element and is linked to the coding sequence of CymR. This switch is as useful in the development of expression systems and cell-based assays for functional genomics as in the generation of viral vectors for gene therapy.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: April 24, 2012
    Assignee: National Research Council of Canada
    Inventors: Bernard Massie, Alaka Mullick, Peter C. K. Lau, Yasuo Konishi
  • Patent number: 8062877
    Abstract: Using site-directed mutagenesis to mutate the Xanthomonas campestris pectate lyase gene, variants of Xanthomonas campestris pectate lyase with improved thermostability and/or enzymatic activity have been expressed in Escherichia coli, and then isolated and purified. The mutant Xanthomonas campestris pectate lyases are more effective than the wild-type enzyme, also expressed in E. coli, in removing pectic compounds from natural hemp fiber.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: November 22, 2011
    Assignee: National Research Council of Canada
    Inventors: Zhizhuang Xiao, Hélène Bergeron, Stephan Grosse, Peter C. K. Lau
  • Publication number: 20100285569
    Abstract: Using site-directed mutagenesis to mutate the Xanthomonas campestris pectate lyase gene, variants of Xanthomonas campestris pectate lyase with improved thermostability and/or enzymatic activity have been expressed in Escherichia coli, and then isolated and purified. The mutant Xanthomonas campestris pectate lyases are more effective than the wild-type enzyme, also expressed in E. coli, in removing pectic compounds from natural hemp fiber.
    Type: Application
    Filed: May 5, 2008
    Publication date: November 11, 2010
    Inventors: Zhiahuang Xiao, Hélène Bergeron, Stephan Grosse, Peter C.K. Lau
  • Publication number: 20100210830
    Abstract: The invention relates to a new “gene-switch” (cumate-inducible switch) for mammalian cells. This switch is as useful in the development of expression systems and cell-based assays for functional genomics as in the generation of viral vectors for gene therapy.
    Type: Application
    Filed: April 28, 2010
    Publication date: August 19, 2010
    Inventors: Bernard MASSIE, Alaka Mullick, Peter C.K. Lau, Yasuo Konishi
  • Patent number: 7745592
    Abstract: The invention relates to a new “gene-switch” (cumate-inducible switch) for mammalian cells. This switch is as useful in the development of expression systems and cell-based assays for functional genomics as in the generation of viral vectors for gene therapy.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: June 29, 2010
    Assignee: National Research Council of Canada
    Inventors: Bernard Massie, Alaka Mullick, Peter C. K. Lau, Yasuo Konishi
  • Patent number: 7541168
    Abstract: Cyclopentanone 1,2-monooxygenase (CPMO) from Comamonas (previously Pseudomonas) sp. strain NCIMB 9872 carries out the second step of a degradation pathway that allows the bacterium to use cyclopentanol as a sole carbon source for growth. In the present invention there is reported the localization of the CPMO-encoding gene (cpnB) on a 4.3-kb SphI fragment, the determination of its sequence. The 550-amino acid CPMO polypeptide (Mr, 62,111) encoded by the gene was found to have 36.5% identity with the sequence of cyclohexanone 1,2-monooxygenase (CHMO) of Acinetobacter sp. strain NCIMB 9871. The 62-kDa CPMO was expressed in E. coli as an IPTG-inducible protein.
    Type: Grant
    Filed: March 28, 2007
    Date of Patent: June 2, 2009
    Assignee: National Research Council of Canada
    Inventors: Hiroaki Iwaki, Yoshie Hasegawa, Peter C. K. Lau
  • Patent number: 7425434
    Abstract: The invention relates to a new strain of Pseudomonas putida (designated as HI-70) and to the isolation, cloning, and sequencing of a cyclododecanone monooxygenase-encoding gene (named cdnB) from said strain. The invention also relates to a new cyclododecanone monooxygenase and to a method of use of the cyclododecanone monooxygenase-encoding gene.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: September 16, 2008
    Assignee: National Research Council of Canada
    Inventors: Hiroaki Iwaki, Yoshie Hasegawa, Peter C. K. Lau
  • Publication number: 20070224668
    Abstract: 4-vinylguaiacol is produced using recombinant E. coli containing a decarboxylase gene from Bacillus pumilis in an aqueous fermentation broth and in an immobilized whole cell system. The 4-vinylguaiacol is extracted and recovered from an organic hydrocarbon solvent, preferably n-octane, whereby the product can readily be separated.
    Type: Application
    Filed: March 21, 2007
    Publication date: September 27, 2007
    Inventors: Jianzhong Yang, Denis Rho, Peter C.K. Lau, Kofi Abokitse
  • Publication number: 20070205577
    Abstract: A human powered ground vehicle is provided and comprises a vehicle frame comprising a rear frame section and a mid-section, the mid-section comprising a forward end and a rearward end, wherein the rear frame section is pivotally connected at a sprocket assembly to the rearward end. Methods of folding and unfolding a foldable vehicle are also provided.
    Type: Application
    Filed: November 21, 2006
    Publication date: September 6, 2007
    Inventor: James C.K. Lau
  • Patent number: 7217559
    Abstract: The invention relates to a new strain of Pseudomonas putida (designated as HI-70) and to the isolation, cloning, and sequencing of a cyclododecanone monooxygenase-encoding gene (named cdnB) from said strain. The invention also relates to a new cyclododecanone monooxygenase and to a method of use of the cyclododecanone monooxygenase-encoding gene.
    Type: Grant
    Filed: September 18, 2002
    Date of Patent: May 15, 2007
    Assignee: National Research Council of Canada
    Inventors: Hiroaki Iwaki, Yoshie Hasegawa, Peter C. K. Lau
  • Patent number: 7214520
    Abstract: Cyclopentanone 1,2-monooxygenase (CPMO) from Comamonas (previously Pseudomonas) sp. strain NCIMB 9872 carries out the second step of a degradation pathway that allows the bacterium to use cyclopentanol as a sole carbon source for growth. In the present invention there is reported the localization of the CPMO-encoding gene (cpnB) on a 4.3-kb SphI fragment, the determination of its sequence. The 550-amino acid CPMO polypeptide (Mt, 62,111) encoded by the gene was found to have 36.5% identity with the sequence of cyclohexanone 1,2-monooxygenase (CHMO) of Acinetobacter sp. strain NCIMB 9871. The 62-kDa CPMO was expressed in E. coli as an IPTG-inducible protein.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: May 8, 2007
    Assignee: National Research Council of Canada
    Inventors: Hiroaki Iwaki, Yoshie Hasegawa, Peter C. K. Lau
  • Patent number: 7091092
    Abstract: A method for forming a self-aligned, recessed channel, MOSFET device that alleviates problems due to short channel and hot carrier effects while reducing inter-electrode capacitance is described. A thin pad oxide layer is grown overlying the substrate and a gate recess, followed by deposition of a thick silicon nitride layer filling the gate recess. The top surface is planarized exposing the pad oxide layer. An additional oxide layer is grown, thickening the pad oxide layer. A portion of the silicon nitride layer is etched away and additional oxide layer is again grown. This forms a tapered oxide layer along the sidewalls of the gate recess. The remaining silicon nitride layer is removed. The oxide layer at the bottom of the gate recess is removed and a gate dielectric layer is grown. Gate polysilicon is deposited filling the gate recess. S/D implantations, metallization, and passivation complete fabrication of the device.
    Type: Grant
    Filed: February 5, 2002
    Date of Patent: August 15, 2006
    Assignees: Chartered Semiconductor Manufacturing Ltd., National University of Singapore
    Inventors: Sneedharan Pillai Sneelal, Francis Poh, James Lee, Alex See, C. K. Lau, Ganesh Shankar Samudra
  • Patent number: 7048289
    Abstract: Apparatus and methods are disclosed for a human-powered vehicle. The vehicle can be a two-wheel, recumbent-style vehicle. The vehicle can be readily disassembled for ease of transport.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: May 23, 2006
    Assignee: JCL Design Inc.
    Inventor: James C. K. Lau
  • Publication number: 20040205834
    Abstract: The invention relates to a new “gene-switch” (cumate-inducible switch) for mammalian cells. This switch is as useful in the development of expression systems and cell-based assays for functional genomics as in the generation of viral vectors for gene therapy.
    Type: Application
    Filed: May 1, 2002
    Publication date: October 14, 2004
    Applicant: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Bernard Massie, Alaka Mullick, Peter C.K. Lau, Yasuo Konishi