Patents by Inventor Célal Ates

Célal Ates has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prodrugs of 2-(3,5-Dichloro-1-methyl-indazol-4-yl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(1-hydroxy-1-methyl-ethyl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]ethanone
    Publication number: 20240083925
    Abstract: The present invention relates to a prodrug of 2-(3,5-dichloro-1-methyl-indazol-4-yl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(1-hydroxy-1-methyl-ethyl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, which prodrug is represented by formula (II).
    Type: Application
    Filed: December 16, 2021
    Publication date: March 14, 2024
    Inventors: Ali Ates, Celal Ates, Laurent Provins
  • Process for the preparation of nitrogen substituted aminotetralins derivatives
    Patent number: 8981121
    Abstract: The present invention provides an alternative synthesis of N-substituted aminotetralines comprising resolution of N-substituted aminotetralins of formula (II), wherein R1, R2 and R3 are as defined for compound of formula (I).
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: March 17, 2015
    Assignee: UCB Pharma GmbH
    Inventors: Celal Ates, Arnaud Schule, Magali Palacio, Paul Deutsch, David Vasselin, Nicolas Carly, Ganesh Phadtare, Swapnil Yerande, Jean-Pierre Delatinne, Maria Luisa Escudero Hernandez, Veronique Pinilla
  • 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses
    Patent number: 8957226
    Abstract: The present invention relates to optically enriched or substantially optically pure 4-substituted-pyrrolidin-2-ones of formula (III), and their uses for the synthesis of 2-oxo-pyrrolidin-1-yl derivatives.
    Type: Grant
    Filed: September 12, 2006
    Date of Patent: February 17, 2015
    Assignee: UCB Pharma S.A.
    Inventors: Celal Ates, Francoise Lurquin, Yannick Quesnel, Arnaud Schule
  • Process for the preparation of nitrogen substituted aminotetralins derivatives
    Patent number: 8729306
    Abstract: The present invention provides an alternative synthesis of N-substituted aminotetralines which synthesis comprises catalytic asymmetric hydrogenation of compounds of general formula (A).
    Type: Grant
    Filed: February 3, 2011
    Date of Patent: May 20, 2014
    Assignee: UCB Pharma GmbH
    Inventors: David Vasselin, Nicolas Carly, Celal Ates
  • Novel Process for the Preparation of Nitrogen Substituted Aminotetralins Derivatives
    Publication number: 20130102794
    Abstract: The present invention provides an alternative synthesis of N-substituted aminotetralines comprising resolution of N-substituted aminotetralins of formula (II), wherein R1, R2 and R3 are as defined for compound of formula (I).
    Type: Application
    Filed: June 24, 2011
    Publication date: April 25, 2013
    Applicant: UCB PHARMA GMBH
    Inventors: Celal Ates, Arnaud Schule, Magali Palacio, Paul Deutsch, David Vasselin, Nicolas Carly, Ganesh Phadtare, Swapnil Yerande, Jean-Pierre Delatinne, Maria Luisa Escudero Hernandez, Veronique Pinilla
  • Novel Process for the Preparation of Nitrogen Substituted Aminotetralins Derivatives
    Publication number: 20120302790
    Abstract: The present invention provides an alternative synthesis of N-substituted aminotetralines which synthesis comprises catalytic asymmetric hydrogenation of compounds of general formula (A).
    Type: Application
    Filed: February 3, 2011
    Publication date: November 29, 2012
    Applicant: UCB PHARMA, S.A.
    Inventors: David Vasselin, Nicolas Carly, Celal Ates
  • 3-carboxy-2-oxo-1-pyrrolidine derivatives and their uses
    Patent number: 8076493
    Abstract: The present invention relates to 3-carboxy-2-oxo-1-pyrrolidine derivatives of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof, and processes using them.
    Type: Grant
    Filed: December 5, 2006
    Date of Patent: December 13, 2011
    Assignee: UCB Pharma, S.A.
    Inventors: Celal Ates, Arnaud Schule
  • 2-Oxo-1-Pyrrolidine Derivatives, Processes For Preparing Them And Their Uses
    Publication number: 20090318708
    Abstract: The present invention relates to optically enriched or substantially optically pure 4-substituted-pyrrolidin-2-ones of formula (III), and their uses for the synthesis of 2-oxo-pyrrolidin-1-yl derivatives.
    Type: Application
    Filed: September 12, 2006
    Publication date: December 24, 2009
    Inventors: Célal Ates, Francoise Lurquin, Yannick Quesnel, Arnaud Schule
  • Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine
    Patent number: 7619085
    Abstract: The present invention relates to (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(R)-pyrrolidone-5-carboxylicacid salt; or (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxycetamide-(R)-pyrrolidone-5-carboxylic salt. The present invention relates also to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide (I) and (R)-2-[4-(4-chlorobenzhydryl) piperazin-1-yl]-ethoxyacetamide (II) by chemical resolution of a mixture. These compounds are respectively intermediates for the synthesis of dextrocetirizine and levocetirizine.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: November 17, 2009
    Assignee: UCB Pharma, S.A.
    Inventors: Magali Palacio, Celal Ates
  • Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of Levetiracetam and analogues
    Patent number: 7563912
    Abstract: The present invention relates to an improved process for the preparation of (S)-(?)-?-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein R1 is methyl or ethyl; and R2 is C?2#191 -C?4#191 alkyl, C?2#191-C?4#191 alkenyl or C?2#191-C?4#191 alkynyl, optionally substituted by one or more halogen, and their preparation processes.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: July 21, 2009
    Assignee: UCB Pharma, S.A.
    Inventors: Celal Ates, John Surtees, Anne-Catherine Burteau, Violeta Marmon, Emile Cavoy
  • 3-Carboxy-2-Oxo-1-Pyrrolidine Derivatives and Their Uses
    Publication number: 20090012313
    Abstract: The present invention relates to 3-carboxy-2-oxo-1-pyrrolidine derivatives of formula (I), geometrical isomers, enantiomers, diastereoisomers, pharmaceutically acceptable salts and all possible mixtures thereof, and processes using them.
    Type: Application
    Filed: December 5, 2006
    Publication date: January 8, 2009
    Applicant: UCB PHARMA, S.A.
    Inventors: Celal Ates, Arnaud Schule
  • Pyroglutamate Salts and Their Use in the Optical Resolution of Intermediates for the Synthesis of Dextrocetirizine and Levocetirizine
    Publication number: 20080269489
    Abstract: The present invention relates to (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt; (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide-(R)-pyrrolidone-5-carboxylic acid salt; or (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxycetamide-(R)-pyrrolidone-5-carboxylic salt. The present invention relates also to a process for preparing (S)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide (I) and (R)-2-[4-(4-chlorobenzhydryl) piperazin-1-yl]-ethoxyacetamide (II) by chemical resolution of a mixture. These compounds are respectively intermediates for the synthesis of dextrocetirizine and levocetirizine.
    Type: Application
    Filed: February 23, 2006
    Publication date: October 30, 2008
    Applicant: UCB PHARMA, S.A.
    Inventors: Magali Palacio, Celal Ates
  • Piperazine derivatives and their use as synthesis intermediates
    Patent number: 7381821
    Abstract: The present invention relates to new enantiomerically pure piperazine derivatives of formula (I) wherein Y represents hydroxy or a leaving group and n is 1, 2, 3, 4 or 5, and to their use as synthesis intermediates, especially for the preparation of pharmaceutically active compounds
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: June 3, 2008
    Assignee: UCB, S.A.
    Inventors: Célal Ates, Emile Cavoy, Didier Bouvy
  • Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues
    Publication number: 20070142647
    Abstract: The present invention relates to an improved process for the preparation of (S)-(-)-?-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein R1 is methyl or ethyl; and R2 is C2-C4 alkyl, C2-C4 alkenyl or C2-C4 alkynyl, optionally substituted by one or more halogen, and their preparation processes.
    Type: Application
    Filed: October 2, 2006
    Publication date: June 21, 2007
    Inventors: Celal Ates, John Surtees, Anne-Catherine Burteau, Violeta Marmon, Emile Cavoy
  • Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of Levetiracetam and analogues
    Publication number: 20060258734
    Abstract: The present invention relates to an improved process for the preparation of (S)-(?)-?-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein R1 is methyl or ethyl; and R2 is C?2#191 -C?4#191 alkyl, C?2#191-C?4#191 alkenyl or C?2#191-C?4#191 alkynyl, optionally substituted by one or more halogen, and their preparation processes.
    Type: Application
    Filed: July 18, 2006
    Publication date: November 16, 2006
    Inventors: Celal Ates, John Surtees, Anne-Catherine Burteau, Violeta Marmon, Emile Cavoy
  • Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues
    Patent number: 7122682
    Abstract: The present invention relates to an improved process for the preparation of (S)-(?)-?-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: October 17, 2006
    Assignee: UCB, S.A.
    Inventors: Celal Ates, John Surtees, Anne-Catherine Burteau, Violeta Marmon, Emile Cavoy
  • Piperazine derivatives and their use as synthesis intermediates
    Publication number: 20060183903
    Abstract: The present invention relates to new enantiomerically pure piperazine derivatives of formula (I) wherein Y represents hydroxy or a leaving group and n is 1, 2, 3, 4 or 5, and to their use as synthesis intermediates, especially for the preparation of pharmaceutically active compounds.
    Type: Application
    Filed: January 20, 2004
    Publication date: August 17, 2006
    Applicant: UCB, S.A.
    Inventors: Celal Ates, Emile Cavoy, Didier Bouvy
  • Oxopyrrolidine compounds, preparations of said compounds and their use in the manufacturing of levetiracetam and analogues
    Publication number: 20040204476
    Abstract: The present invention relates to an improved process for the preparation of (S)-(−)-&agr;-ethyl-2-oxo-1-pyrrolidine acetamide and analogues thereof. The invention also relates to compounds of the general formula (6) wherein R1 is methyl or ethyl; and R2 is C?2#19 1-C?4#191 alkyl, C?2#191 -C?4#191 alkenyl or C?2#191-C?4#191 alkynyl, optionally substituted by one or more halogen, and their preparation processes.
    Type: Application
    Filed: February 10, 2004
    Publication date: October 14, 2004
    Inventors: Celal Ates, John Surtees, Anne-Catherine Burteau, Violeta Marmon, Emile Cavoy