Patents by Inventor CÉLIA DE SOUSA

CÉLIA DE SOUSA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF PKS 13 PROTEIN CODING FOR CONDENSASE OF MYCOLIC ACIDS OF MYCOBACTERIA AND RELATED STRAINS AS AN ANTIBIOTICS TARGET
    Publication number: 20100267112
    Abstract: The invention relates to a novel enzyme involved in the biosynthesis of mycolic acids and to the use thereof for the screening of antibiotics, especially antimycobacterials. The invention more particularly relates to the Pks13 protein which catalyzes Claisen condensation or malonic condensation in mycolates between an acyl-CoA molecule or an acyl-AMP molecule and an acylmalonyl-CoA molecule to form an intermediate ?-cEto acyl or ?-cEto ester.
    Type: Application
    Filed: September 29, 2008
    Publication date: October 21, 2010
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PARIS SUD XI
    Inventors: CHRISTOPHE GUILHOT, MAMADOU DAFFE, CHRISTINE HOUSSIN, DAMIEN PORTEVIN, CÉLIA DE SOUSA
  • Use of pks 13 protein coding for condensase of mycolic acids of mycobacteria and related strains as an antibiotics target
    Publication number: 20070196889
    Abstract: The invention relates to a novel enzyme involved in the biosynthesis of mycolic acids and to the use thereof for the screening of antibiotics, especially antimycobacterials. The invention more particularly relates to the Pks13 protein which catalyzes Claisen condensation or malonic condensation in mycolates between an acyl-CoA molecule or an acyl-AMP molecule and an acylmalonyl-CoA molecule to form an intermediate ?-cEto acyl or ?-cEto ester.
    Type: Application
    Filed: September 6, 2004
    Publication date: August 23, 2007
    Inventors: Christophe Guilhot, Mamadou Daffe, Christine Houssin, Damien Portevin, Celia De Sousa