Patents by Inventor C. M. Amy Chen

C. M. Amy Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of promoting cardiac cell proliferation
    Publication number: 20050261189
    Abstract: The present invention provides novel methods and compositions for promoting proliferation and/or regeneration.
    Type: Application
    Filed: April 18, 2005
    Publication date: November 24, 2005
    Inventors: Glenn Larsen, Martha Marvin, Dean Li, Elizabeth Wang, C. M. Amy Chen, Steven Shamah
  • Polynucleotide sequences encoding proteins involved in myogenesis
    Patent number: 5885797
    Abstract: A novel gene, Inhibitor of MyoD Family (I-mf), is provided which encodes novel proteins, I-mfa, I-mfb and I-mfc, involved in regulation of myogenesis during vertebrate development. I-mf is highly expressed in the sclerotome of developing vertebrates and is postulated to play an important role in patterning of the somite and determination sclerotomal cell fate. A unique, C-terminal interactional domain of the I-mf protein mediates physical interactions between I-mfa and members of the MyoD family of transcriptional activators and functions to inhibit transactivation of muscle specific genes by MyoD family members, thereby repressing myogenesis. Further characterization of I-mf activity shows that I-mf associates with MyoD family member proteins and retains them in the cytoplasm by masking their nuclear localization signals.
    Type: Grant
    Filed: August 27, 1996
    Date of Patent: March 23, 1999
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: C. M. Amy Chen, Norbert Kraut, Mark Groudine, Harold Weintraub, deceased