Abstract: A method for producing the health-benefits of exercise including (but not limited to) the treatment and prevention of cachexia, other wasting disorders, cancer, atherosclerosis, heart disease, acute or chronic autoimmune disease, chronic inflammatory disease, alcoholic hepatitis, non-alcoholic hepatitis, rheumatoid arthritis, osteoarthritis, type II diabetes, insulin insensitivity, Parkinson's disease, Alzheimer's disease, and any other condition caused or mediated by chronic oxygen radical damage or by chronic chemical toxicities using diacylglycerol or any of its' derivatives or analogues; phospholipids, including but not limited to phosphatidylinositol or any of its' derivatives or analogues; hydrogen peroxide; any lipid peroxide or lipid-soluble peroxide (including but not limited to short-, medium-, or long-chain fatty acid peroxides); any water soluble peroxide derivative which retains any of the reactive properties of the original peroxide; oxygen radical generating system capable of generating superox

Abstract: A method for screening agents to determine possible use as treatment and prevention drugs is provided. More specifically, cells, living organisms, mammals, or tissue are treated with the compound or agent of interest and then measured for transient activation of stress-response pathways. Activation of any of the genes or signaling molecules associated with a stress-response pathway is then determined. A transient activation of any of the genes within these pathways of transcription activation indicates the agent is a candidate for a drug, or a source of a drug for the treatment and prevention of cachexia, other wasting disorders, cancer, atherosclerosis, heart disease, autoimmune disease, chronic inflammatory disease, alcoholic hepatitis, non-alcoholic hepatitis, rheumatoid arthritis, osteoarthritis, type II diabetes, insulin insensitivity, Parkinson's disease, Alzheimer's disease, and any other condition caused or mediated by chronic oxygen radical damage or by chronic chemical toxicities.