Patents by Inventor C. Randell Brown

C. Randell Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Correction of genetic defects using chemical chaperones
    Patent number: 6541195
    Abstract: A method of improving a phenotypic defect in a cell that contains a conformationally defective target protein wherein the conformational defect causes the phenotype defect, comprising contacting a first cell that expresses said conformationally defective target protein with an amount of a protein stabilizing agent that is effective to improve the conformational defect, thereby improving the phenotypic defect of the first cell in comparison with a second cell having the same conformationally defective target protein and phenotypic defect, wherein the second cell is not contacted with the protein stabilizing agent.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: April 1, 2003
    Assignee: The Regents of the University of California
    Inventors: William J. Welch, C. Randell Brown, Jörg Tatzelt
  • Correction of genetic defects using chemical chaperones
    Publication number: 20010021500
    Abstract: A method of improving a phenotypic defect in a cell that contains a conformationally defective target protein wherein the conformational defect causes the phenotype defect, comprising contacting a first cell that expresses said conformationally defective target protein with an amount of a protein stabilizing agent that is effective to improve the conformational defect, thereby improving the phenotypic defect of the first cell in comparison with a second cell having the same conformationally defective target protein and phenotypic defect, wherein the second cell is not contacted with the protein stabilizing agent.
    Type: Application
    Filed: March 30, 2001
    Publication date: September 13, 2001
    Inventors: William J. Welch, C. Randell Brown, Jorg Tatzelt
  • Correction of genetic defects using chemical chaperones
    Patent number: 6270954
    Abstract: A method of improving a phenotypic defect in a cell that contains a conformationally defective target protein wherein the conformational defect causes the phenotype defect, comprising contacting a first cell that expresses said confonnationally defective target protein with an amount of a protein stabilizing agent that is effective to improve the conformational defect, thereby improving the phenotypic defect of the first cell in comparison with a second cell having the same conformationally defective target protein and phenotypic defect, wherein the second cell is not contacted with the protein stabilizing agent.
    Type: Grant
    Filed: April 13, 1999
    Date of Patent: August 7, 2001
    Assignee: The Regents of The University of California
    Inventors: William J. Welch, C. Randell Brown, Jörg Tatzelt
  • Correction of genetic defects using chemical chaperones
    Patent number: 5900360
    Abstract: The present invention provides methods of improving phenotypic defects that are caused by conformationally defective target proteins. The methods of the invention comprise exposing a cell that expresses a conformationally defective target protein with an amount of a protein stabilizing agent that is effective to improve the phenotypic defect. Nonlimiting examples of protein stabilizing agents include dimethylsulfoxide (DMSO), deuterated water, trimethylamine N-oxide (TMAO). Nonlimiting examples of defective target proteins to be treated include the cystic fibrosis transmembrane conductance regulator (CFTR) protein and prion proteins. In one embodiment, the invention provides methods for detecting protein stabilizing agents. In another embodiment, the invention provides methods for detecting cells and pathological conditions caused by improper folding and protein processing.
    Type: Grant
    Filed: April 9, 1997
    Date of Patent: May 4, 1999
    Inventors: William J. Welch, C. Randell Brown, Jorg Tatzelt