Patents by Inventor César Sánchez Reillo

César Sánchez Reillo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glycosylated indolocarbazoles, method for obtaining same and uses thereof
    Patent number: 8598132
    Abstract: Glycosylated indolocarbazoles, method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and the production of rebeccamycin and staurosporine derivatives. The invention also relates to bacterial strains that are of use for the production of rebeccamycin and staurosporine derivatives. Lastly, the rebeccamycin and staurosporine derivatives described herein are applicable to the field of human health, specifically for manufacturing drugs that are of use in the treatment of tumour, neurological and inflammatory diseases.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: December 3, 2013
    Assignees: Universidad de Oviedo, Entrechem, S.L.
    Inventors: Aaroa Pérez Salas, César Sánchez Reillo, Alfredo Fernández Braña, Carmen Méndez Fernández, Jose Antonio Salas Fernández, Francisco Morís Varas
  • Method of obtaining idolocarbazoles using biosynthetic rebeccamycin genes
    Patent number: 8207321
    Abstract: Method for production of indolocarbazoles by using rebeccamycin biosynthetic genes. The invention is based on utilization of rebeccamycin biosynthetic genes from Saccharothrix aerocolonigenes for production of indolocarbazoles in related microorganisms (Streptomyces spp.). Method includes the isolation of a DNA fragment from Saccharothrix aerocolonigenes ATCC39243 containing the rebeccamycin biosynthesis gene cluster and the expression of these genes in Streptomyces albus, achieving production of rebeccamycin and derivatives. The invention is suitable for use in the pharmaceutical field.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: June 26, 2012
    Assignee: Universidad De Oviedo
    Inventors: César Sánchez Reillo, Alfredo Fernandez Braña, José Antonio Salas Fernandez, Carmen Mendez Fernandez
  • GLYCOSYLATED INDOLECARBAZOLES, METHOD FOR OBTAINING SAME AND USES THEREOF
    Publication number: 20110136753
    Abstract: Glycosylated indolocarbazoles, method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and the production of rebeccamycin and staurosporine derivatives. The invention also relates to bacterial strains that are of use for the production of rebeccamycin and staurosporine derivatives. Lastly, the rebeccamycin and staurosporine derivatives described herein are applicable to the field of human health, specifically for manufacturing drugs that are of use in the treatment of tumour, neurological and inflammatory diseases.
    Type: Application
    Filed: April 6, 2009
    Publication date: June 9, 2011
    Applicants: UNIVERSIDAD DE OVIEDO, ENTRECHEM S.L.
    Inventors: Aaroa Pêrez Salas, César Sánchez Reillo, Alfredo Fernández Braña, Carmen Méndez Fernández, Jose Antonio Salas Fernández, Francisco Morís Varas
  • Method of Obtaining Idolocarbazoles Using Biosynthetic Rebeccamycin Genes
    Publication number: 20080004326
    Abstract: Method for production of indolocarbazoles by using rebeccamycin biosynthetic genes. The invention is based on utilization of rebeccamycin biosynthetic genes from Saccharothrix aerocolonigenes for production of indolocarbazoles in related microorganisms (Streptomyces spp.). Method includes the isolation of a DNA fragment from Saccharothrix aerocolonigenes ATCC39243 containing the rebeccamycin biosynthesis gene cluster and the expression of these genes in Streptomyces albus, achieving production of rebeccamycin and derivatives. The invention is suitable for use in the pharmaceutical field.
    Type: Application
    Filed: October 17, 2002
    Publication date: January 3, 2008
    Inventors: Cesar Sanchez Reillo, Alfredo Fernandez Brana, Jose Antonio Salas Fernandez, Carmen Mendez Fernandez