Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (I SR) and for treating related diseases, disorders, and conditions.

Abstract: A microfluidic device includes: a first microfluidic channel; a second microfluidic channel extending along the first microfluidic channel; and a first array of islands separating the first microfluidic channel from the second microfluidic channel, in which each island is separated from an adjacent island in the array by an opening that fluidly couples the first microfluidic channel to the second microfluidic channel, in which the first microfluidic channel, the second microfluidic channel, and the islands are arranged so that a fluidic resistance of the first microfluidic channel increases relative to a fluidic resistance of the second microfluidic channel along a longitudinal direction of the first microfluidic channel such that, during use of the microfluidic device, a portion of a fluid sample flowing through the first microfluidic channel passes through one or more of the openings between adjacent islands into the second microfluidic channel.

Abstract: Ultrasonic surgical instruments including a handle housing, a switch frame, and a switch assembly are disclosed. The switch assembly may include a first switch arrangement movably supported on a distal portion of the handle housing and selectively movable relative to a first switch contact supported by the switch frame. The switch assembly may further include a second switch arrangement including a right switch button movably supported on a right side of the handle housing and selectively movable relative to a right switch contact supported by the switch frame, and a left switch button movably supported on a left side of the handle housing and selectively movable relative to a left switch contact supported by the switch frame. The first and second switch arrangements may be configured to be selectively actuatable by a single hand supporting the handle housing.

Abstract: An electrically insulating gas composition comprises C3F7CN, in an amount between 22% and 70% by volume and one or more inert gas selected from the list consisting of nitrogen, carbon dioxide (CO2), air and argon.

Abstract: A compound having the following structure of Formula (I): or a stereoisomer of the compound, tautomer of the compound, pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R8, A, X, Z, and Y are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

Abstract: A method is disclosed for a wideband Wi-Fi network analyzer that detects the presence of packets corresponding to a desired waveform type, and routing detected signals to a bank of demodulator resources, i.e., channel processors, based on availability and need. Furthermore, to mitigate the case of Wi-Fi 802.11b where the DSSS preamble is subject to false detection on neighboring channels, a neighbor channel filter, NCF, is also disclosed.

Abstract: An integrated bioreactor and reseeding chamber system and a separate bioreactor and complimentary reseeding chamber system comprising a bioreactor and a separate reseeding chamber. The bioreactor comprises a bioreactor chamber; a first groove attached to the bioreactor chamber; a second groove removably attached to the bioreactor chamber. A first bar and a second bar may be removably inserted into the first groove and the second groove respectively. Each of the first bar and the second bar may have at least an oval hole. At least a crossbar is attached substantially perpendicularly to the first bar and the second bar to form a crossbar-bars construct through the oval holes. A knob may be installed on each of the crossbars. The reseeding chamber may comprise dividers fixedly attached to a bottom of the reseeding chamber.

Abstract: Devices, systems, and methods for explosion resistance include an explosion-resistant enclosure and a lid assembly. The lid assembly includes a lid for enclosing an opening of the explosion-resistant enclosure, and a graphical display assembly for presenting visual information regarding the analysis equipment.

Abstract: Filter assemblies are described. In particular, a filter securement assembly for receiving and retaining a filter media in an exhaust hood includes a main panel defining a first end and an opposed second end, a first retainment surface adjacent the first end of the main panel, a first retainment lip adjacent the first retainment surface, a second retainment surface adjacent the second end of the main panel and a second retainment lip adjacent the second retainment surface.

Abstract: An improved material, preferably a biomaterial, is provided which is the reaction product of S8 and a free fatty acid or free fatty acid-containing material, preferably in the presence of metal. The improved material can be made by a method comprising reacting S8 with a free fatty acid to obtain a FFA/S8 composite and shaping the FFA/S8 composite into a solid form. The solid form of said FFA/S8 is melted to form melted FFA/S8 and the melted FFA/S8 is optionally applied as a coating on a surface, used as an adjacent material to a surface or the FFA/S8 composite itself is shaped thereby forming a device and preferably a medical device.

Abstract: A supply system for use with agricultural equipment includes a storage system, a metering system, and a distribution system. The storage system holds dry granules therein. The metering system is configured to meter the dry granules at a determined rate. The distribution system includes a conduit coupled with the manifold to receive the dry granules therefrom and a plurality of outlet tubes in fluid communication with the conduit to direct the dry granules toward a receiver unit at the determined rate.

Abstract: In some examples, a method of processing a substrate comprises applying a photoresist (PR) onto a surface of the substrate, pre-exposing the PR to ultra violet (UV) light before depositing or etching a metal oxide (MO) layer onto the PR, and depositing or etching a MO layer onto the PR subsequent to pre-exposing the PR to UV light.

Abstract: A method includes receiving, and storing in a computer-readable storage medium, asset base criteria for one or more properties of a participant, where the asset base criteria characterize the respective one or more properties of the participant. Acquisition criteria for one or more properties one or more other participants anticipate purchasing are also received and stored in a computer-readable medium, where the acquisition criteria characterize the respective one or more properties the one or more other participants anticipating purchasing. The method also includes providing, to the participant, a number of properties the one or more other participants anticipate purchasing that have acquisition criteria matching the asset base criteria of the respective one or more properties of the participant. In this regard, the number of properties is provided for display as a measure of demand for the one or more properties of the participant.

Abstract: An aircraft cooling system comprises an evaporator, condenser, an accumulator, and a pump system. The evaporator is configured to cool a set of heat loads in an aircraft using a liquid. The liquid forms a vapor in response to cooling the set of heat loads. The condenser is configured to receive the vapor from the evaporator and cool the vapor in which cooling the vapor forms the liquid. The accumulator is configured to receive the liquid from the condenser and store the liquid. The pump system is configured to pump the liquid stored in the accumulator to the evaporator.

Abstract: A method executed by at least one server, comprising: receiving, from a first monitored system comprising an internal combustion engine and a first sensor, a first signal associated with a first occurrence and a second occurrence of an internal combustion engine event and first measurement data of the first sensor; determining a first measurement from the first measurement data and a second measurement from the first measurement data based on the first and second occurrences, respectively; determining a reference measurement; determining a first reference deviation; determining a second reference deviation; after determining the first reference deviation is less than a first reference threshold and the second reference deviation is less than a second reference threshold, determining a measurement deviation; comparing the measurement deviation to a measurement threshold; and after determining the measurement deviation satisfies the measurement threshold, determining a first exhibited useful life of the first s

Abstract: A microfluidic device includes: a first microfluidic channel; a second microfluidic channel extending along the first microfluidic channel; and a first array of islands separating the first microfluidic channel from the second microfluidic channel, in which each island is separated from an adjacent island in the array by an opening that fluidly couples the first microfluidic channel to the second microfluidic channel, in which the first microfluidic channel, the second microfluidic channel, and the islands are arranged so that a fluidic resistance of the first microfluidic channel increases relative to a fluidic resistance of the second microfluidic channel along a longitudinal direction of the first microfluidic channel such that, during use of the microfluidic device, a portion of a fluid sample flowing through the first microfluidic channel passes through one or more of the openings between adjacent islands into the second microfluidic channel.

Abstract: Systems and methods for continuous injection of fluid. In some examples these apparatuses may include a manifold, a pair of reciprocating pistons, and an actuation control that may apply both suction (aspiration) and injection of fluid as part of the same actuation.

Abstract: 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.

Abstract: A hybrid additive manufacturing and thermoforming method is provided. The method includes additively manufacturing one or more reinforcing structures directly onto a polymer sheet before shaping the polymer sheet onto a mold and/or while the polymer sheet is shaped onto a mold. By leveraging the design control of additive manufacturing, reinforcing structures can be deposited onto the polymer sheet as needed based on the intended application. These reinforcing structures can comprise standard infill patterns or complex custom core designs. The present invention provides an innovative way in which to mass produce custom thermoformed components with an optimal mechanical response.

Abstract: A container for storage of molten material from an industrial facility, and method of manufacture thereof, is provided to maximize internal volume of the container while providing structural stability. The container includes walls having rounded convex-shaped edges at each wall junction. A first head is connected to the walls at a first end of the container, and a second head closes the second end of the container. The second head is connected to the walls at a second end of the container. Corners are defined at the intersection of the walls with the first head and second head at the first end and the second end respectively. A first flange is connected to the first head to receive molten material, and the first head is shaped as a tapered shoulder to smoothly transition from the first flange to the junction of the walls.