Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: Systems, methods, and computer-readable storage devices are disclosed for simulated choral audio chatter in communication systems. One method including: receiving audio data from each of a plurality of users participating in a first group of a plurality of groups for an event using a communication system; generating first simulated choral audio chatter based on the audio data received from each of the plurality of users in the first group; and providing the generated first simulated choral audio data to at least one user of a plurality of users of the event.

Abstract: One embodiment provides an apparatus comprising a memory stack including multiple memory dies and a parallel processor including a plurality of multiprocessors. Each multiprocessor has a single instruction, multiple thread (SIMT) architecture, the parallel processor coupled to the memory stack via one or more memory interfaces. At least one multiprocessor comprises a multiply-accumulate circuit to perform multiply-accumulate operations on matrix data in a stage of a neural network implementation to produce a result matrix comprising a plurality of matrix data elements at a first precision, precision tracking logic to evaluate metrics associated with the matrix data elements and indicate if an optimization is to be performed for representing data at a second stage of the neural network implementation, and a numerical transform unit to dynamically perform a numerical transform operation on the matrix data elements based on the indication to produce transformed matrix data elements at a second precision.

Abstract: A recharging system for recharging batteries or providing power to an implantable device includes an electric coil adapted to be coupled to the implantable device, the electric coil defining a coil interior and a coil exterior. A magnetic component is coupled to the electric coil and adapted to at least partially surround the implantable device. A mechanical actuator is attached to the magnetic component, the mechanical actuator converting compression motion into motion of the magnetic component relative to the electric coil.

Abstract: Surgical constructs and methods are provided for securing soft tissue to bone. One exemplary embodiment of a construct is formed from a suture filament and includes two terminal ends of filament and an intermediate portion disposed along at least a portion of a length extending between the terminal ends. The construct can have a first terminal end that is the first terminal end of the filament, and a second terminal end that includes a loop. The loop can be formed by disposing the second terminal end of the filament within a volume of a portion of the intermediate portion of the filament. In some disclosed methods, both terminal ends of the filament can be passed through tissue when performing soft tissue repairs. Various other embodiments of constructs and methods are provided, including constructs having two or more filaments associated with an anchor and methods of using such constructs.

Abstract: Provided herein are agents that modulate histone acetylation and pathways downstream thereof, and methods for the treatment and prevention of organ injury therewith. In particular, provided herein are combinations of histone deacetylase (HDAC) inhibitors, bromodomain and extraterminal-containing protein family (BET) inhibitors, promoters of histone acetyl transferase (HAT) activity, mineralocorticoid receptor (MR) antagonists, nuclear factor erythroid 2-related factor 2 (NRF2) activators, and/or aldehyde dehydrogenase (ALDH) agonists, and methods of use thereof for the treatment and prevention of heart injury.

Abstract: Aspects of this present disclosure relate to hybrid conference user interface. The hybrid conference interface provides an establishing shot before the meeting begins that places meeting attendees in a specific spatial arrangement, such as in specific seats around a conference table. Upon starting the conference, the hybrid user interface renders an appropriate perspective view of the meeting that is tailored to each attendee's perspective while also being spatially consistent for the entire group of attendees. Allowing attendees to place themselves where they want gives attendees a sense of physical space that helps them stay spatially oriented relative to the other people and resources in the room.

Abstract: A plurality of events are extracted from a plurality of electronic health records associated with a first patient. The extracted plurality of events are analyzed to identify a plurality of stimulus events and a plurality of response events. An association between a first stimulus event and a first response event is determined. A stimulus-response (SR) variable is generated for the first patient based at least in part on the determined association, and the generated SR variable is integrated into one or more predictive cognitive models.

Abstract: Surgical constructs and methods are provided for securing soft tissue to bone. One exemplary embodiment of a construct is formed from a suture filament and includes two terminal ends of filament and an intermediate portion disposed along at least a portion of a length extending between the terminal ends. The construct can have a first terminal end that is the first terminal end of the filament, and a second terminal end that includes a loop. The loop can be formed by disposing the second terminal end of the filament within a volume of a portion of the intermediate portion of the filament. In some disclosed methods, both terminal ends of the filament can be passed through tissue when performing soft tissue repairs. Various other embodiments of constructs and methods are provided, including constructs having two or more filaments associated with an anchor and methods of using such constructs.

Abstract: Methods and devices are provided for anchoring a ligament or tendon to bone. In general, various inserter tools are provided for simultaneously delivering an expandable sheath and an expander into bone. With both components of the implant mounted on the same tool, the sheath and a ligament can be advanced into a bone hole and the expander, which trails behind the sheath during delivery of the sheath, can be advanced into the sheath to expand the sheath and anchor the sheath and ligament within the bone hole.

Abstract: Aspects of this present disclosure relate to hybrid conference user interface. The hybrid conference interface provides an establishing shot before the meeting begins that places meeting attendees in a specific spatial arrangement, such as in specific seats around a conference table. Upon starting the conference, the hybrid user interface renders an appropriate perspective view of the meeting that is tailored to each attendee's perspective while also being spatially consistent for the entire group of attendees. Allowing attendees to place themselves where they want gives attendees a sense of physical space that helps them stay spatially oriented relative to the other people and resources in the room.

Abstract: Various bone anchor assemblies and methods are provided for anchoring tissue to bone. In one embodiment, an anchor assembly for anchoring a tendon to bone is provided and includes a substantially cylindrical sheath having bone-engaging surface features formed on an external surface thereof, and having an inner lumen formed therein and extending from an open proximal end to a substantially closed distal. The substantially closed distal end includes at least one tendon anchoring feature extending distally therefrom and configured to facilitate anchoring of a tendon to bone. The anchor assembly further includes an expander having a generally elongate cylindrical configuration and being sized and shaped to be received within the inner lumen of the sheath.

Abstract: Aspects of this present disclosure relate to hybrid conference user interface. The hybrid conference interface provides an establishing shot before the meeting begins that places meeting attendees in a specific spatial arrangement, such as in specific seats around a conference table. Upon starting the conference, the hybrid user interface renders an appropriate perspective view of the meeting that is tailored to each attendee's perspective while also being spatially consistent for the entire group of attendees. Allowing attendees to place themselves where they want gives attendees a sense of physical space that helps them stay spatially oriented relative to the other people and resources in the room.

Abstract: A plurality of attributes are extracted from a plurality of electronic health records, where each electronic health record is associated with a patient in a plurality of patients. Additionally, a training data set and a scoring data set are generated based on the plurality of attributes, and a patient similarity model is trained based on the training data set. A precision cohort is identified, where the precision cohort includes patients in the plurality of patients from the scoring data set that are similar to a first patient based on an electronic health record of the first patient and the similarity model. At least one result statistic for each of a plurality of treatments given to patients in the precision cohort is determined, and a first treatment of the plurality of treatments is selected for the first patient based at least in part on the determined result statistics.

Abstract: A bioreactor device includes a solid substrate having a first face and a second face. The solid substrate at least partially defines a perfusion channel, a plurality of chambers, a fluidic inlet, and a fluidic outlet. A first sheet disposed over the first face and a second sheet disposed over the second face. Characteristically, the combination of the solid substrate, the first sheet and the second sheet define the perfusion channel and each chamber of the plurality of chambers. The plurality of chambers are arranged in rows of chambers in which adjacent chambers are positioned at opposite side of the perfusion channel. The perfusion channel extends from the fluidic inlet and the fluidic outlet having a serpentine path along each row of chambers with each chamber being in fluid communication with the perfusion channel.

Abstract: Methods and devices are provided for anchoring a ligament or tendon to bone. In one embodiment, a surgical implant is provided having a sheath and an expander that is received within the sheath. Various delivery tools, including a sheath inserter and a driver, are also provided. In use, the sheath inserter can be used to position a tendon within a prepared bone hole, and it can be used to deliver the sheath with a guidewire coupled thereto into the bone hole. The driver can be provided for delivering the expander into the sheath. A loader can optionally be used to load the driver and expander onto the guidewire coupled to the implanted sheath.

Abstract: A mechanism is provided in a data processing system comprising a processor and a memory, the memory comprising instructions that are executed by the processor to specifically configure the processor to implement a question prediction and answering engine for predicting questions a medical professional is attempting to answer. An interaction monitoring component monitors interaction of a medical professional with a patient electronic medical record (EMR). A question selection component selects a set of questions the medical professional is attempting to obtain an answer to from the patient EMR. The question prediction and answering engine analyzes the patient EMR to generate a set of answers to the set of questions from at least a portion of the patient EMR and outputs a report correlating the set of questions and the set of answers to the medical professional.

Abstract: Methods and systems are provided for securing tissue to bone. A suture anchor can include an elongate body having a proximal end and a distal end and an external surface with a plurality of longitudinally spaced bone-engaging features formed at least partially circumferentially thereon over at least a portion of a length of the suture anchor. The proximal end can have a lumen extending at least partially into the elongate body and the distal end can have a suture engaging feature proximate thereto. A first series of bone-engaging features can have a dimension that increases from a distal to a proximal end of each bone-engaging feature of the first series of bone-engaging features. A second series of bone-engaging features can have a dimension that decreases from a distal to a proximal end of each bone-engaging feature of the second series of bone-engaging features.

Abstract: Provided herein are organ preservation solutions and methods of use thereof for preserving organs. In particular, provided herein are preservation solutions comprising a mineralocorticoid receptor antagonist, aldehyde dehydrogenase agonist, and/or histone deacetylase inhibitor, and methods of perfusing and storing an organ while awaiting transplantation or non-transplant surgery.

Abstract: A notation assistant system has a machine learning system, a notation processing system, a scoring system, and a suggestion system. The machine learning system trains a classifier for rating a factor related to a clinical narrative note that describes a patient's health status. The notation processing system processes a clinical narrative note and the scoring system determines a factor rating, such as a completion score or a clarity score. The scoring system provides the factor rating to an end-user device to display to a user. The notation assistant system is configured to perform a method as a user is entering a clinical narrative note to provide real-time feedback, such as the factor rating. The suggestion system is configured to provide suggestions for modifying the clinical narrative note to improve the rating factor. The notation assistant system applies to patient health conditions such as a health status of a patient's heart for a patient receiving care for congestive heart failure.