Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

Abstract: Systems and methods for maintaining an electronic health records system, including a server storing a medical records database. Requests for medical data for a patient in a master problem list are received from a user device, and appropriate list permissions are determined and granted for hierarchical derivative problem lists. Annotated data is received at the server from a user device based on annotations made to a derivative problem list, and problem lists are updated with the received annotated data in real time. The received annotated data is compared with current entries using natural language processing to detect duplicate entries, the duplicate entries are iteratively detected and removed from the master problem list, and non-duplicate entries are stored in authorized derivative problem lists based on the natural language processing and list update permissions for each of the derivative problem lists.

Abstract: Described herein are methods, compositions, and systems for multiplex editing using Cas enzymes or editing of T-cells or related cells using Cas enzymes.

Abstract: Disclosed herein are engineered nucleases and nuclease systems, including chimeric nucleases and chimeric nuclease systems. Engineered and chimeric nucleases disclosed herein include nucleic acid guided nuclease. Additionally disclosed herein are methods of generating engineered nucleases and methods of using the same.

Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.

Abstract: The present disclosure concerns methods and compositions for inhibiting replication of viruses within an organism in need thereof. In some cases, the methods and compositions can be applicable to aquacultured organisms. The aquacultured organisms can include, but are not limited to, crustacean organisms such as shrimp.

Abstract: The present disclosure provides for endonuclease enzymes as well as methods of using such enzymes or variants thereof.

Abstract: A LADOR circuit is in signal communication with a pixel array. The LADOR circuit is configured to generate an integrator reset voltage based on a resistance of the at least one heated bolometer pixel, and to detect laser energy incident on the at least one heated bolometer pixel based on a comparison between the integrator reset voltage and an input threshold voltage (Vthreshold).

Abstract: Technology is disclosed herein for the integration of spreadsheet environments with an LLM service. In an implementation, an application receives a natural language input from a user associated with visualization of data hosted by the application. The application generates a prompt for a large language model (LLM) service based on the user input and the visualization and submits the prompt to the LLM service. The application receives a reply to the prompt from the LLM service and modifies the visualization based on the reply from the LLM service. In an implementation, the data includes spreadsheet data and the visualization includes a chart. In some implementations, to modify the visualization, the application generates source code based on the reply from the LLM service when the classification of the natural language input is a command.

Abstract: The present disclosure provides systems and methods for transposing a cargo nucleotide sequence to a target nucleic acid site. These systems and methods may comprise a first double-stranded nucleic acid comprising the cargo nucleotide sequence, wherein the cargo nucleotide sequence is configured to interact with a retrotransposase, and the retrotransposase, wherein said retrotransposase is configured to transpose the cargo nucleotide sequence to the target nucleic acid site.

Abstract: A trigger sense circuit includes a pseudo-differential comparator circuit in signal communication with a pixel array. The pseudo-differential comparator circuit includes a first input in signal communication with a reference pixel group included in the pixel array to receive a pixel reference voltage, and a second input in signal communication with a target pixel group included in the pixel array to receive a pixel target voltage. The pseudo-differential comparator circuit is configured to selectively operate in a calibration mode to remove false trigger events and a comparison mode to detect at least one overheated pixel included in the target pixel group.

Abstract: The present disclosure provides for endonuclease enzymes having HEPN domains, as well as methods of using such enzymes or variants thereof.

Abstract: Methods and systems of measurement for blown film lines are provided. The sensing system includes a terahertz (THz) sensor positioned adjacent to a film bubble extruded from a blown film die, and a sensor support configured to guide the THz sensor around the circumference of the film bubble to measure its film thickness.

Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.

Abstract: The present disclosure provides systems and methods for transposing a cargo nucleotide sequence to a target nucleic acid site. These systems and methods may comprise a first double-stranded nucleic acid comprising the cargo nucleotide sequence, wherein the cargo nucleotide sequence is configured to interact with a transposase, and the transposase, wherein said transposase is configured to transpose the cargo nucleotide sequence to the target nucleic acid site.

Abstract: Cationic copolymers having pendant N-allylimidazolium-containing groups are provided. The cationic copolymers can be used, for example, to provide anion exchange membranes for use in electrochemical cells such as fuel cells, electrolyzers, batteries, and electrodialysis cells. The anion exchange membranes typically have good mechanical properties and ionic conductivity.

Abstract: One embodiment of the present invention sets forth a technique for analyzing a transcript of a structured interaction. The technique includes determining a first portion of the transcript that corresponds to a first dialogue act. The technique also includes matching the first portion of the transcript to a first component of a script for the structured interaction based on a first set of embeddings for the first portion of the transcript and a second set of embeddings associated with the first component of the script. The technique further includes causing a first mapping between the first portion of the transcript and the first component to be outputted.

Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

Abstract: The present disclosure provides for endonuclease enzymes as well as methods of using such enzymes or variants thereof.