Abstract: Provided herein are multi-chain chimeric polypeptides and uses thereof for treating cancer, aging related diseases or conditions, and/or an infectious disease. Further provided, are methods for stimulating an immune cell, inducing or increasing proliferation of an immune cell, and/or inducing differentitation of an immune cell into a memory-like immune cell by contacting the immune cell with the multi-chain chimeric polypeptides disclosed herein.

Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in the treatment of an unresectable, advanced, recurrent, and/or metastatic solid tumor or an unresectable, advanced, recurrent, and/or metastatic solid cancer.

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.

Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in generating, and/or stimulating, and/or increasing proliferation of different subsets of CD8+ T cells. Further, provided herein are pharmaceutical compositions comprising the multi-chain chimeric polypeptides. In addition, kits comprising the pharmaceutical compositions comprising the multi-chain chimeric polypeptides disclosed herein are also provided.

Abstract: An aircraft comprises a machine body which encloses a turbofan gas turbine engine. The turbofan gas turbine engine includes a heat exchanger module, fan assembly, compressor module, turbine module, and exhaust module. The heat exchanger module communicates with the fan assembly by an inlet duct. The heat exchanger module includes first heat transfer elements that transfer heat energy from a first fluid within the transfer elements to an airflow passing over a surface of the transfer elements before entry of the airflow into a fan assembly inlet. The first fluid contained within transfer elements has a temperature, and the airflow passing over the transfer element surface has a temperature. The turbofan gas turbine engine further includes at least one second heat transfer element, with the or each second heat transfer element transfers heat energy from the first fluid to a second fluid.

Abstract: A shade matching method for a tooth obtains a plurality of digitized tooth shade references, obtains a three-dimensional (3D) surface representation of a tooth and associated color information defined on the three-dimensional (3D) surface, selects a region on the three-dimensional (3D) surface representation of the tooth, determines a plurality of correspondences with the common tooth shape of all the tooth shade references, computes color difference with each of the tooth shade reference from the plurality of tooth shade references, and records the label corresponding to the shade reference with a smallest difference.

Abstract: An apparatus and method for reducing a pressure differential across a turbine 19 of a gas turbine engine 10 during a shaft break event, comprises a pressure equalization apparatus 300, 400, 500, 600, 700 configured to introduce a pressurised fluid into a core airflow A at a region downstream of the turbine 19, wherein a rearward movement of the turbine 19 or a shaft 26 in a shaft break event directly actuates the pressure equalisation apparatus 300, 400, 500, 600, 700 to directly increase a local pressure at the downstream region 29 of the turbine 19 and thereby reduce the pressure differential across the turbine 19. The reduction in the pressure differential may result in a reduction in the acceleration of the turbine 19.

Abstract: In some implementations, a device may obtain first data associated with one or more accounts. The device may process the first data to obtain clustering information associated with the first data. The device may cluster the first data into one or more clusters based on the clustering information. The device may identify, via a second machine learning model, one or more deviation patterns associated with a portion of the first data that is included in a cluster of the one or more clusters. The device may determine, for the cluster, one or more operations to be performed to mitigate deviations based on the one or more deviation patterns. The device may perform an action, that is based on the one or more operations, associated with second data grouped into the cluster.

Abstract: Techniques are disclosed relating to improving memory reliability. In some embodiments, memory circuitry includes memory cells configured to store data, interface circuitry, and on-die error correcting code (ECC) circuitry. The ECC circuitry may check read data from the memory cells for errors and correct detected correctable errors to generate corrected data. The memory circuitry may provide read data to a requesting circuit via the interface circuitry, including one or more sets of corrected data from the on-die ECC circuitry. The memory circuitry may provide a decoding status flag (DSF) via the interface circuitry, including to: set the DSF to a first value in response to no error being detected for a given set of provided read data, set the DSF to a second value in response to a correctable error that was detected and corrected by the on-die ECC circuitry to provide a given set of read data, and set the DSF to a third value in response to an uncorrectable error detected by the on-die ECC circuitry.

Abstract: A modular floating platform system includes a detachable floating buoy providing a body tethered to a seafloor with a plurality of mooring lines and coupled to a subsea production system via one or more communication lines, and a plurality of floating surface facilities, each floating surface facility providing a standardized bottom interface matable with the detachable floating buoy. A latching mechanism individually couples each floating surface facility to the detachable floating buoy when each floating surface facility is individually mated to the detachable floating buoy. One or more communication couplings place each floating surface facility in communication with the subsea production system via the one or more communication lines when each floating surface facility is individually mated to the detachable floating buoy.

Abstract: Provided herein are methods of treating an aging-related disease or inflammatory disease in a subject that include (i) a therapeutically effective amount of an NK cell activating agent and/or an NK cell and/or monoclonal antibody; and (ii) a therapeutically effective amount of a Treg cell activating agent and/or a Treg cell and/or a monoclonal antibody and/or AGE inhibitor.

Abstract: The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL-15 variants of the invention.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

Abstract: A handheld optical apparatus for imaging a sample has an interferometer having at least output and collection waveguides formed on a photonic integrated circuit substrate. A light source generates light of wavelengths above a threshold wavelength. A first signal detector obtains an interference signal from the interferometer between a first portion of the light scattered from the sample and a reference portion of the light. A processor is programmed with instructions that perform optical coherence tomography processing on the obtained interference signal.

Abstract: An adenovirus or adenoviral vector is described that includes a non-native nucleotide sequence capable of expressing a chimeric protein comprising an N-terminal nucleotide binding domain of transactivation response element DNA-binding protein (TDP-43), a C-terminal domain derived from a splicing repressor, and an autoregulatory element. Methods of using the adenovirus or adenoviral vector to treat degenerative diseases such as inclusion body myocytosis, amyotrophic lateral sclerosis, and frontotemporal dementia are also described.

Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

Abstract: Provided herein are methods of killing or reducing the number of naturally-occurring and/or treatment-induced senescent cells and diseased cells in a subject in need thereof, decreasing the accumulation of naturally-occurring and/or treatment-induced senescent cells and diseased cells in a subject in need thereof, that include administering to the subject a therapeutically effective amount of one or more common gamma-chain family cytokine receptor activating agent(s) and/or one or more agent(s) that result(s) in a decrease in the activation of a TGF-? receptor.

Abstract: An affinity chromatography resin comprising an anti-tissue factor antibody or antigen-binding fragment thereof attached to a base resin, and methods of using the same.