Abstract: A fastener driver includes a cylinder, a moveable piston positioned within the cylinder, and a driver blade attached to the piston and movable therewith between a top-dead-center (TDC) position and a bottom-dead-center (BDC) position. A lifter is operable to move the driver blade from the BDC position toward the TDC position. A transmission is provided for providing torque to the lifter. The lifter includes a hub and a plurality of lugs extending therefrom. Each lug is engageable with the driver blade when moving the driver blade from the BDC position toward the TDC position. The hub and the lugs are integrally formed as a single piece. The lifter includes a first side and an opposite second side. Each of the first side and the second side is flat.

Abstract: A fastener driver includes an outer cylinder having a cylindrical first end and an opposite, second end, an inner cylinder positioned within the outer cylinder, a moveable piston positioned within the inner cylinder, and a driver blade attached to the piston and movable therewith between a top-dead-center position and a bottom-dead-center position along a drive axis. The outer cylinder defining a longitudinal axis and a storage chamber configured to be filled with pressurized gas. The inner cylinder being in communication with the pressurized gas within the storage chamber. A frame has first end adjacent the cylindrical first end of the outer cylinder and a second end extending outward from the cylindrical first end of the outer cylinder in the direction of the longitudinal axis. The frame is integrally formed with the outer cylinder as a single piece and a nosepiece supported by the frame.

Abstract: A continuous container crane device may include a first track having a continuous shape and a second track having a continuous shape. Preferably, the first track may be substantially parallel to the second track. One or more trolleys may be movably coupled to the first track and to the second track so that the trolleys are configured to move in a continuous movement path (starts and finishes at the same place) defined by the first and second track. Each trolley may include a lifting mechanism that may be coupled to a container spreader which may be removably coupled to shipping containers for the transport of shipping containers to and from trucks with a chassis trailer, all types of intermodal railroad flat cars, ships and other water traveling vessels, container storage lots, etc.

Abstract: A system, methods, and apparatus for point-in-time requirement tracking are disclosed. In an example embodiment, requirements for a project are stored in a database communicatively coupled to a server, the requirements including at least a first requirement stored in a first record and a second requirement stored in a second record. The server receives changes to the first requirement and the second requirement during the edit session and stores the changed first requirement to a third record and the changed second requirements to a fourth record. The server then provides the first and third records to a client device so that the client device can concurrently display the first requirement as specified in the first record and the first requirement as specified in the third record.

Abstract: Methods and apparatus to monitor media presentations are disclosed. Example methods disclosed herein include presenting information via a display of a media device, the information indicating that monitor software in the media device can be enabled, the monitor software to monitor media presented by the media device, the monitor software to be disabled by default. Disclosed example methods also include detecting a first user input that is to authorize the monitor software in the media device to be enabled, and in response to detection of the first user input: (i) enabling the monitor software in the media device to generate and report at least one of video fingerprints, audio fingerprints, video watermarks or audio watermarks representative of media presented by the media device, and (ii) transmitting, via a network interface, a notification to a remote monitoring entity to indicate that the monitor software in the media device has been enabled.

Abstract: Methods and apparatus to monitor media presentations are disclosed. Example methods disclosed herein include presenting information via a display of a media device, the information indicating that monitor software in the media device can be enabled, the monitor software to monitor media presented by the media device, the monitor software to be disabled by default. Disclosed example methods also include detecting a first user input that is to authorize the monitor software in the media device to be enabled, and in response to detection of the first user input: (i) enabling the monitor software in the media device to generate and report at least one of video fingerprints, audio fingerprints, video watermarks or audio watermarks representative of media presented by the media device, and (ii) transmitting, via a network interface, a notification to a remote monitoring entity to indicate that the monitor software in the media device has been enabled.

Abstract: A system, methods, and apparatus for point-in-time requirement tracking are disclosed. In an example embodiment, requirements for a project are stored in a database communicatively coupled to a server, the requirements including at least a first requirement stored in a first record and a second requirement stored in a second record. The server receives changes to the first requirement and the second requirement during the edit session and stores the changed first requirement to a third record and the changed second requirements to a fourth record. The server then provides the first and third records to a client device so that the client device can concurrently display the first requirement as specified in the first record and the first requirement as specified in the third record.

Abstract: Abnormally long r(CUG)n repeat expansion is believed to be the major cause of Myotonic dystrophy type 1 (DM1) because it binds to muscleblind-like 1 (MBNL 1) protein which regulates RNA splicing, leading to the mis-splicing of more than 100 pre-mRNAs. The rational design of oligomers with alternating bisamidine and melamine structure resulted in good binding affinity to the RNA target because of a multivalent effect. The oligomers also showed excellent activity in disrupting nuclear foci, reversing the mis-splicing of IR minigene, and sabotaging the toxic RNA biosynthesis. Excellent activity in Drosophila based DM1 models was also observed for the oligomers, rescuing the climbing ability of the flies upon oral treatment.

Abstract: Methods and apparatus to monitor media presentations are disclosed. Example methods disclosed herein include presenting information via a display of a media device, the information indicating that monitor software in the media device can be enabled, the monitor software to monitor media presented by the media device, the monitor software to be disabled by default. Disclosed example methods also include detecting a first user input that is to authorize the monitor software in the media device to be enabled, and in response to detection of the first user input: (i) enabling the monitor software in the media device to generate and report at least one of video fingerprints, audio fingerprints, video watermarks or audio watermarks representative of media presented by the media device, and (ii) transmitting, via a network interface, a notification to a remote monitoring entity to indicate that the monitor software in the media device has been enabled.

Abstract: Methods and apparatus to monitor media presentations are disclosed. Example methods disclosed herein include presenting information via a display of a media device, the information indicating that monitor software in the media device can be enabled, the monitor software to monitor media presented by the media device, the monitor software to be disabled by default. Disclosed example methods also include detecting a first user input that is to authorize the monitor software in the media device to be enabled, and in response to detection of the first user input: (i) enabling the monitor software in the media device to generate and report at least one of video fingerprints, audio fingerprints, video watermarks or audio watermarks representative of media presented by the media device, and (ii) transmitting, via a network interface, a notification to a remote monitoring entity to indicate that the monitor software in the media device has been enabled.

Abstract: Abnormally long r(CUG)n repeat expansion is believed to be the major cause of Myotonic dystrophy type 1 (DM1) because it binds to muscleblind-like 1 (MBNL 1) protein which regulates RNA splicing, leading to the mis-splicing of more than 100 pre-mRNAs. The rational design of oligomers with alternating bisamidine and melamine structure resulted in good binding affinity to the RNA target because of a multivalent effect. The oligomers also showed excellent activity in disrupting nuclear foci, reversing the mis-splicing of IR minigene, and sabotaging the toxic RNA biosynthesis. Excellent activity in Drosophila based DM1 models was also observed for the oligomers, rescuing the climbing ability of the flies upon oral treatment.

Abstract: A method of scale inhibition treatment of a water system comprising introducing an aqueous scale inhibiting composition into the water system wherein the aqueous scale inhibiting composition comprises a carboxylated hyperbranched polyglycerol.

Abstract: A system, methods, and apparatus for point-in-time requirement tracking are disclosed. In an example embodiment, requirements for a project are stored in a database communicatively coupled to a server, the requirements including at least a first requirement stored in a first record and a second requirement stored in a second record. The server receives changes to the first requirement and the second requirement during the edit session and stores the changed first requirement to a third record and the changed second requirements to a fourth record. The server then provides the first and third records to a client device so that the client device can concurrently display the first requirement as specified in the first record and the first requirement as specified in the third record.

Abstract: A system, methods, and apparatus for point-in-time requirement tracking are disclosed. In an example embodiment, requirements for a project are stored in a database communicatively coupled to a server, the requirements including at least a first requirement stored in a first record and a second requirement stored in a second record. The server receives changes to the first requirement and the second requirement during the edit session and stores the changed first requirement to a third record and the changed second requirements to a fourth record. The server then provides the first and third records to a client device so that the client device can concurrently display the first requirement as specified in the first record and the first requirement as specified in the third record.

Abstract: The present invention provides microcapsules with good barrier properties and the ability to release encapsulated hydrophobic liquids at low and high pH.

Abstract: Methods and apparatus to monitor media presentations are disclosed. An example apparatus includes a registration data receiver to obtain demographic information. A logging data receiver is to, when enabled, collect first monitoring information identifying first media, the logging data receiver to receive the first monitoring information from a monitor of a second media device separate from the first media device. An overlay controller is to present a monitoring agreement to the user via an output of the first media device. A first data controller enables the logging data receiver to collect the first monitoring information if the monitoring agreement is accepted, and does not enable the logging data receiver if the monitoring agreement is not accepted. The first data controller is to determine that the first data controller is to act as a master monitor. The first monitoring information is transmitted to a central facility via the master monitor.

Abstract: Methods and apparatus to monitor media presentations are disclosed. Example methods disclosed herein include presenting information via a display of a media device, the information indicating that monitor software in the media device can be enabled, the monitor software to monitor media presented by the media device, the monitor software to be disabled by default. Disclosed example methods also include detecting a first user input that is to authorize the monitor software in the media device to be enabled, and in response to detection of the first user input: (i) enabling the monitor software in the media device to generate and report at least one of video fingerprints, audio fingerprints, video watermarks or audio watermarks representative of media presented by the media device, and (ii) transmitting, via a network interface, a notification to a remote monitoring entity to indicate that the monitor software in the media device has been enabled.

Abstract: Methods of maintaining or restoring joint function in a canine in need thereof by allowing the canine to lie on a pad are provided. The pad includes one or more layers of a spacer textile, where the spacer textile includes a top surface, a bottom surface, and a plurality of spacer fibers therebetween. The one or more layers of a spacer textile, when in contact with a joint of a canine, provides an upward force attenuation onto the joint.

Abstract: The invention provides compounds, compositions and therapeutic methods. The compounds and compositions can be used for the treatment of myotonic dystrophy. The compounds can selectively bind to CUG repeats in RNA, or to CTG repeats in DNA, and inhibit replication of the nucleic acids. RNA-targeted therapeutic agents for the treatment of myotonic dystrophy type 1 (DM1) are described. In one embodiment, two bisamidinium ligands are linked using “click” chemistry to form a heterodimer that is a potent inhibitor of the MBNL1-rCUGexp complex (KI=25±8 nM), is relatively non-toxic to HeLa cells, dissolves nuclear foci, corrects >80% of the IR misregulated alternative splicing in DM1 model cells (1 ?M), and shows improvement of disease phenotypes in a DM1 Drosophila model.