Abstract: A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target cells bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target cells from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target cells bound to magnetic beads on the surface of the plate. The microfluidic detection system includes a pump flowing the fluid through the detector component at high flow rates of milliliters per minute for high throughput detection of target cells.

Abstract: A device for weighing micro- and nano-sized particles.

Abstract: A method for measuring mass of a micro- and nano-sized particle. The method includes placing the micro- or nano-sized particle on a resonator having an oscillator and a first and second cantilevered arms with interdigitating finger, energizing the oscillator at a selective frequency thereby causing mechanical vibration in the first and second cantilevered arms, directing a light beam from a light source onto the interdigitating fingers, sensing intensity of light of the reflected diffraction pattern by at least one photodetector positioned about at least one of the modes, varying the frequency by sweeping a range of frequencies and correlating the sensed intensity to mass to thereby determine the mass of the micro- or nano-sized particle.

Abstract: A device for weighing micro- and nano-sized particles.

Abstract: A method for measuring mass of a micro- and nano-sized particle. The method includes placing the micro- or nano-sized particle on a resonator having an oscillator and a first and second cantilevered arms with interdigitating finger, energizing the oscillator at a selective frequency thereby causing mechanical vibration in the first and second cantilevered arms, directing a light beam from a light source onto the interdigitating fingers, sensing intensity of light of the reflected diffraction pattern by at least one photodetector positioned about at least one of the modes, varying the frequency by sweeping a range of frequencies and correlating the sensed intensity to mass to thereby determine the mass of the micro- or nano-sized particle.

Abstract: A device for weighing micro- and nano-sized particles. The device includes a base portion, an oscillator coupled to the base portion and configured to vibrate the base portion, a first cantilevered beam coupled to the base portion, a second cantilevered beam coupled to the base portion, a first plurality of fingers coupled to the first cantilevered beam near the tip inwardly pointing toward the second cantilevered beam, and a second plurality of fingers coupled to the second cantilevered beam near the tip inwardly pointing toward the first cantilevered beam.

Abstract: A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target cells bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target cells from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target cells bound to magnetic beads on the surface of the plate. The microfluidic detection system includes a pump flowing the fluid through the detector component at high flow rates of milliliters per minute for high throughput detection of target cells.

Abstract: A device for weighing micro- and nano-sized particles. The device includes a base portion, an oscillator coupled to the base portion and configured to vibrate the base portion, a first cantilevered beam coupled to the base portion, a second cantilevered beam coupled to the base portion, a first plurality of fingers coupled to the first cantilevered beam near the tip inwardly pointing toward the second cantilevered beam, and a second plurality of fingers coupled to the second cantilevered beam near the tip inwardly pointing toward the first cantilevered beam.