Abstract: The invention discloses a (9?-H)-pimarane skeleton diterpenoids with anti-colon cancer activity and a derivative thereof, and further discloses a preparation method and application of the compounds above; the invention finds that novel skeleton compounds 1 and 2 have certain inhibition effects on colon cancer cells, wherein the compound 2 has remarkable anti-proliferation effects on two colon cancer cell lines HT-29 and SW620, and the effects are both stronger than those of a positive drug 5-fluorouracil, so that the compound has the potential of being developed into a new anti-colon cancer drug.

Abstract: Disclosed are two compounds with a new skeleton of ursane triterpenoid—ent-kaurane diterpenoid dimer and a preparation method thereof. According to the invention, chemical ingredients of a tuber of a West African plant I. trichantha are deeply studied, and separated to obtain two compounds Bisicacinol B (1) and Bisicacinol C (2), and the compounds are both a natural hybrid dimer formed by a DielsAlder addition or Michael addition reaction between a ursane triterpenoid with a unique spiro structure and an ent-kaurane diterpenoid. Pharmaceutical experiments show that the Bisicacinol B (1) and Bisicacinol C (2) prepared by the invention have a significant anti-tumor activity (on a pancreatic cancer, a colon cancer, a lung cancer, or a liver cancer), and can also be combined with an amphotericin B to exert a coordinated and synergistic anti-Candida albicans activity.

Abstract: The invention discloses a (9?-H)-pimarane skeleton diterpenoids with anti-colon cancer activity and a derivative thereof, and further discloses a preparation method and application of the compounds above; the invention finds that novel skeleton compounds 1 and 2 have certain inhibition effects on colon cancer cells, wherein the compound 2 has remarkable anti-proliferation effects on two colon cancer cell lines HT-29 and SW620, and the effects are both stronger than those of a positive drug 5-fluorouracil, so that the compound has the potential of being developed into a new anti-colon cancer drug.

Abstract: A block model constructing method for complex geological structures is provided. The method comprises the following steps: a) making a triangle mesh description of a layer plane or a fault plane; b) judging whether two triangles intersect, and finding out the intersection points if they intersect; c) performing a geometric consistency and topological consistency processing within every intersectant triangle; d) extracting an enclosing block to acquire an interface constituted of peripheral edges of the enclosing block, and defining a geological attribute of the enclosing block to form a three-dimensional model block. The method needs not to solve difficult equation sets with large computation, thus simplifying the constructing method.