Abstract: The present application relates to the technical field of polyaryletherketone, and discloses a preparation method for a coating material containing high-temperature self-crosslinking fluorine-containing polyaryletherketone. A molecular chain of the high-temperature self-crosslinking fluorine-containing polyaryletherketone contains two crosslinking groups of a styrene group and a thioether group, and its structural formula is: Herein, the value range of m is 1-40%, the value range of n is 60-99%, and R is a group that removes a phenolic hydroxyl group from hexafluorobisphenol A. In the high-temperature curing process after film coating, the crosslinking reaction occurs to form a crosslinked polymer coating layer, thereby a coating surface with good moisture and heat resistance, wear resistance, and low friction coefficient is formed.

Abstract: The present invention provides a nanoparticle including at least one poly(vinyl alcohol) (PVA) having a molecular weight of from about 10 kDa to about 200 kDa, substituted with one or more moieties selected from: a therapeutic agent having a boronic acid moiety, wherein the therapeutic agent is covalently linked to the PVA via a boronate ester bond; a crosslinking group having a disulfide moiety, wherein the crosslinking group is covalently linked to the PVA, and a porphyrin, wherein the porphyrin is covalently linked to the PVA. Use of the nanoparticles for tumor detection and the treatment of diseases, including methods for photodynamic therapy and photothermal therapy, are also described.

Abstract: The present invention provides a nanoparticle including at least one polyvinyl alcohol) (PVA) having a molecular weight of from about 10 kDa to about 200 kDa, substituted with one or more moieties selected from: a therapeutic agent having a boronic acid moiety, wherein the therapeutic agent is covalently linked to the PVA via a boronate ester bond; a crosslinking group having a disulfide moiety, wherein the crosslinking group is covalently linked to the PVA, and a porphyrin, wherein the porphyrin is covalently linked to the PVA. Use of the nanoparticles for tumor detection and the treatment of diseases, including methods for photodynamic therapy and photothermal therapy, are also described.