Abstract: A seismic data acquisition device and a seismic data acquisition method are disclosed. The seismic data acquisition device includes an anti-aliasing filter, a first conversion circuit, a second conversion circuit, and a controller. The anti-aliasing filter has an input configured to receive seismic data, which is generally an analog signal. The anti-aliasing filter has an output connected to an input of the first conversion circuit and an input of the second conversion circuit, respectively. The first conversion circuit has an output connected to a first input of the controller. The second conversion circuit has an output connected to a second input of the controller. The seismic data acquisition device and method enable wide dynamic seismic data acquisition with high resolution over the full amplitude range of the (seismic data) input signal.

Abstract: Here provided is a method for multiplex nucleic acid analysis. The method includes steps of hybridizing sets of probes to target nucleic acids in a sample, ligating the hybridized probes, amplifying the ligated probes, and assaying the amplification products to determining the presence, absence, or quantity of the target nucleic acids in the sample. The multiplexity is made available in part by adding detectable moieties and inserting stuffer sequences in primers so that amplification products may be identified on the basis of the detectable moieties and fragment sizes. Also provided is a sensitive method of detecting small copy number changes by measuring the copy number of a plurality of target sites in the nucleic acid in a test sample in comparison to a control sample and then determining the copy number of the nucleic acid based on the measured copy number of the plurality of target sites. Further provided is a kit for multiplex nucleic acid analysis and for small copy number change determination.

Abstract: Here provided is a method for multiplex nucleic acid analysis. The method includes steps of hybridizing sets of probes to target nucleic acids in a sample, ligating the hybridized probes, amplifying the ligated probes, and assaying the amplification products to determining the presence, absence, or quantity of the target nucleic acids in the sample. The multiplexity is made available in part by adding detectable moieties and inserting stuffer sequences in primers so that amplification products may be identified on the basis of the detectable moieties and fragment sizes. Also provided is a sensitive method of detecting small copy number changes by measuring the copy number of a plurality of target sites in the nucleic acid in a test sample in comparison to a control sample and then determining the copy number of the nucleic acid based on the measured copy number of the plurality of target sites. Further provided is a kit for multiplex nucleic acid analysis and for small copy number change determination.