Patents by Inventor Caihua Peng

Caihua Peng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for resolution of citalopram intermediate 5-cyano diol
    Patent number: 10508076
    Abstract: Provided is a method for resolution of formula 4-[4-dimethylamino-1-(4-fluorophenyl)-1-hydroxylbutyl]-3-hydroxy-methyl benzonitrile as an enantiomer thereof, comprising the following steps: a salt of (S)-4-[4-dimethylamino-1-(4-fluorophenyl)-1-hydroxylbutyl]-3-hydroxymethyl benzonitrile with a resolving agent D-(+)di-p-toluoyl tartaric acid was crystallized in a resolving solvent; the method is characterized in that the resolving solvent is an ether solvent. Also provided is a new crystal form of the resolved intermediate.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: December 17, 2019
    Assignee: Zhejiang huahai Pharmaceuticals Co., Ltd.
    Inventors: Zunjun Liang, Siqi Hu, Caihua Peng, Wenfeng Huang, Qifeng Lu, Guoliang Tu
  • METHOD FOR RESOLUTION OF CITALOPRAM INTERMEDIATE 5-CYANO DIOL
    Publication number: 20190185418
    Abstract: Provided is a method for resolution of formula 4-[4-dimethylamino-1-(4-fluorophenyl)-1-hydroxylbutyl]-3-hydroxy-methyl benzonitrile as an enantiomer thereof, comprising the following steps: a salt of (S)-4-[4-dimethylamino-1-(4-fluorophenyl)-1-hydroxylbutyl]-3-hydroxymethyl benzonitrile with a resolving agent D-(+)di-p-toluoyl tartaric acid was crystallized in a resolving solvent; the method is characterized in that the resolving solvent is an ether solvent. Also provided is a new crystal form of the resolved intermediate.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 20, 2019
    Inventors: Zunjun LIANG, Siqi Hu, Caihua PENG, Wenfeng HUANG, Qifeng LU, Guoliang TU
  • Method for resolution of citalopram intermediate 5-cyano diol
    Patent number: 10287240
    Abstract: Provided is a method for resolution of formula 4-[4-dimethylamino-1-(4-fluorophenyl)-1-hydroxylbutyl]-3-hydroxy-methyl benzonitrile as an enantiomer thereof, comprising the following steps: a salt of (S)-4-[4-dimethylamino-1-(4-fluorophenyl)-1-hydroxylbutyl]-3-hydroxymethyl benzonitrile with a resolving agent D-(+)di-p-toluoyl tartaric acid was crystallized in a resolving solvent; the method is characterized in that the resolving solvent is an ether solvent. Also provided is a new crystal form of the resolved intermediate.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: May 14, 2019
    Assignee: Zhejiang Hushai Pharmaceuticals Co., Ltd.
    Inventors: Zunjun Liang, Siqi Hu, Caihua Peng, Wenfeng Huang, Qifeng Lu, Guoliang Tu
  • Method for preparing citalopram diol intermediate
    Patent number: 10227293
    Abstract: The present invention relates to a method for preparing a citalopram diol represented by formula IV, comprising the following steps: in the existence of an auxiliary reagent of metal salt, allowing 5-cyanophthalide to sequentially subjected to Grignard addition reactions with p-fluorophenyl magnesium halide and N, N-dimethylaminopropyl magnesium halide in an organic solvent; and after the reactions are completed, performing hydrolysis and separation to obtain citalopram diol represented by formula IV. In the present invention, by adding an auxiliary reagent of metal salt, the activity and the selectivity of the Grignard reactions are remarkably improved, and the reaction yield is obviously enhanced.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: March 12, 2019
    Assignees: Zhejiang Huahai Pharmaceutical Co., Ltd, Zhejiang Huahai Licheng Pharmaceutical Co., Ltd, Zhejiang Huahai Jiancheng Pharmaceutical Co., Ltd
    Inventors: Zunjun Liang, Weifeng Xiao, Caihua Peng, Wenfeng Huang, Guoliang Tu
  • METHOD FOR PREPARING CITALOPRAM DIOL INTERMEDIATE
    Publication number: 20180162805
    Abstract: The present invention relates to a method for preparing a citalopram diol represented by formula IV, comprising the following steps: in the existence of an auxiliary reagent of metal salt, allowing 5-cyanophthalide to sequentially subjected to Grignard addition reactions with p-fluorophenyl magnesium halide and N, N-dimethylaminopropyl magnesium halide in an organic solvent; and after the reactions are completed, performing hydrolysis and separation to obtain citalopram diol represented by formula IV. In the present invention, by adding an auxiliary reagent of metal salt, the activity and the selectivity of the Grignard reactions are remarkably improved, and the reaction yield is obviously enhanced.
    Type: Application
    Filed: June 9, 2015
    Publication date: June 14, 2018
    Inventors: Zunjun LIANG, Weifeng XIAO, Caihua PENG, Wenfeng HUANG, Guoliang TU
  • METHOD FOR RESOLUTION OF CITALOPRAM INTERMEDIATE 5-CYANO DIOL
    Publication number: 20170240505
    Abstract: Provided is a method for resolution of formula 4-[4-dimethylamino-1-(4-fluorophenyl)-1-hydroxylbutyl]-3-hydroxy-methyl benzonitrile as an enantiomer thereof, comprising the following steps: a salt of (S)-4-[4-dimethylamino-1-(4-fluorophenyl)-1-hydroxylbutyl]-3-hydroxymethyl benzonitrile with a resolving agent D-(+)di-p-toluoyl tartaric acid was crystallized in a resolving solvent; the method is characterized in that the resolving solvent is an ether solvent. Also provided is a new crystal form of the resolved intermediate.
    Type: Application
    Filed: November 14, 2014
    Publication date: August 24, 2017
    Inventors: Zunjun LIANG, Siqi HU, Caihua PENG, Wenfeng HUANG, Qifeng LU, Guoliang TU
  • Dehumidifier
    Patent number: D723149
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: February 24, 2015
    Assignee: Gree Electric Appliances, Inc. Of Zhuhai
    Inventors: Hui Huang, Lei Peng, Sha Li, Shaolin Chen, Caihua Peng, Ruisha Cai, Yan Ruan, Youmei Zhang, Zhaigu Fu, Jianqun Yang, Li Zhang, Zhi An, Qiuhua Liu
  • Dehumidifier
    Patent number: D729365
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: May 12, 2015
    Assignee: Gree Electric Appliances, Inc. of Zhuhai
    Inventors: Zhiqiang Yuan, Yan Ruan, Caihua Peng, Zhen Zhang
  • Dehumidifier
    Patent number: D735845
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: August 4, 2015
    Assignee: Gree Electric Appliances, Inc. Of Zhuhai
    Inventors: Hui Huang, Wenjun Li, Sha Li, Shaolin Chen, Caihua Peng, Yan Ruan, Youmei Zhang, Guojian Wang, Xiaohong Qiu, Chaoxin Wang, Mingxiao Liu
  • Air conditioner
    Patent number: D754830
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: April 26, 2016
    Assignee: GREE ELECTRIC APPLIANCES, INC. OF ZHUHAI
    Inventors: Hui Huang, Zhen Zhang, Sha Li, Shaolin Chen, Yan Ruan, Zhaigu Fu, Yongliang An, Caihua Peng, Tangtang Gu, Heqing Zheng
  • Humidification spraying fan
    Patent number: D797271
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: September 12, 2017
    Assignee: GREE ELECTRIC APPLIANCES, INC. OF ZHUHAI
    Inventors: Zecheng Yang, Sha Li, Caihua Peng, Weirui Liu, Henghua Wu, Zhaigu Fu, Zhaoyang Wu
  • Air conditioner
    Patent number: D846722
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: April 23, 2019
    Assignee: Gree Electric Appliances, Inc. of Zhuhai
    Inventors: Ke Mu, Luan Qin, Jingjing Wang, Huanlong Wu, Huihui Wang, Sha Li, Caihua Peng, Zhaigu Fu
  • Air conditioners
    Patent number: D949305
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: April 19, 2022
    Assignee: Gree Electric Appliances, Inc. of Zhuhai
    Inventors: Ke Mu, Luan Qin, Jingjing Wang, Huanlong Wu, Huihui Wang, Sha Li, Caihua Peng, Zhaigu Fu