Patents by Inventor Caike Jin
Caike Jin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230383327Abstract: A method for semisynthesis of NMN involving adenosine includes the steps in the same reaction system: (A) a step of adenosine, a phosphate and a sugar that can be metabolized by yeast cells reacting, catalyzed by yeast cells, to generate ATP; (B) a step of enzymatic phosphorylation of NR, and a corresponding step of NR reacting with ATP under the catalysis of NRK to generate NMN and ADP. In this way, efficient synthesis of NMN can be realized during a process of ATP generation and recycling, which can simplify the process and reduce emissions.Type: ApplicationFiled: June 21, 2022Publication date: November 30, 2023Inventors: Caike JIN, Yuan ZHAO
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Publication number: 20230383329Abstract: An adenosine-involved fully enzymatic synthesis method for NMN includes the steps under the same reaction system: (A) reacting, under the catalytic action of a yeast cell, adenosine, phosphate and sugar that is metabolizable by a yeast cell, so as to generate ATP; and (B) generating NMN by an enzymatic reaction including the step of under the action of NAMPT, reacting nicotinamide, PRPP and ATP to generate NMN, ADP and phosphate. In this way, a series of reactions such as the generation (regeneration) of ATP, the synthesis of NMN and the utilization of ATP are performed in one reaction system in a unified manner, and thus efficient synthesis of NMN can be implemented.Type: ApplicationFiled: June 21, 2022Publication date: November 30, 2023Inventors: Caike JIN, Yuan ZHAO
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Patent number: 8486676Abstract: The invention discloses a carrier made from an organic foam having open pores for enzymes or cells immobilization and the methods for preparing immobilized enzymes or cells. The invention uses flocculation and crosslinking technology to immobilize enzyme protein or cells on the organic foam material having open pores. The resultant immobilized products have larger specific surface area, higher specific activity and can be made into various shapes.Type: GrantFiled: September 25, 2006Date of Patent: July 16, 2013Assignee: Bioright Worldwide Company LimitedInventors: Caike Jin, Jun Wang
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Patent number: 8067561Abstract: This invention provides a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases with improved catalytic activity and thermostability obtained by using recombinant techniques. These recombinant glucose isomerases comprise amino acid variation including phenylalanine (Phe) at position 139, alanine (Ala) at position 182, serine (Ser) at position 187, and glutamine (Gin) at position 299, and carry at least one additional mutated amino acid at position 87, position 217, position 260 or position 276, and possess a higher catalytic activity than that of the wild-type when using D-glucose as substrate. These recombinant glucose isomerases can be used for direct production of high fructose corn syrup containing 55% [wt] or higher concentration of fructose.Type: GrantFiled: March 15, 2010Date of Patent: November 29, 2011Assignee: BioRight Worldwide Company LimitedInventors: Jun Wang, Caike Jin, Rongzhao Fu, Dong Shen
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Patent number: 7923222Abstract: This invention provides a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases with improved catalytic activity and thermostability obtained by using recombinant techniques. These recombinant glucose isomerases comprise amino acid variation including phenylalanine (Phe) at position 139, alanine (Ala) at position 182, serine (Ser) at position 187, and glutamine (Gin) at position 299, and carry at least one additional mutated amino acid at position 87, position 217, position 260 or position 276, and possess a higher catalytic activity than that of the wild-type when using D-glucose as substrate. These recombinant glucose isomerases can be used for direct production of high fructose corn syrup containing 55% [wt] or higher concentration of fructose.Type: GrantFiled: March 15, 2010Date of Patent: April 12, 2011Assignee: Geneharbor (HK) Technologies Ltd.Inventors: Jun Wang, Caike Jin, Rongzhao Fu, Dong Shen
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Patent number: 7919300Abstract: This invention describes a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases having improved catalytic activity and thermostability. The recombinant glucose isomerases can be used for direct production of fructose syrup containing 55 wt % or higher concentration of fructose, or used for the production of fructose syrup containing less than 55 wt % fructose.Type: GrantFiled: July 28, 2004Date of Patent: April 5, 2011Inventors: Jun Wang, Rongzhao Fu, Dong Shen, Caike Jin, Zhangming Liu, Junming Chen
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Publication number: 20100227365Abstract: This invention provides a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases with improved catalytic activity and thermostability obtained by using recombinant techniques. These recombinant glucose isomerases comprise amino acid variation including phenylalanine (Phe) at position 139, alanine (Ala) at position 182, serine (Ser) at position 187, and glutamine (Gin) at position 299, and carry at least one additional mutated amino acid at position 87, position 217, position 260 or position 276, and possess a higher catalytic activity than that of the wild-type when using D-glucose as substrate. These recombinant glucose isomerases can be used for direct production of high fructose corn syrup containing 55% [wt] or higher concentration of fructose.Type: ApplicationFiled: March 15, 2010Publication date: September 9, 2010Applicant: GENEHARBOR (HK) TECHNOLOGIES LTD.Inventors: Jun Wang, Caike Jin, Rongzhao Fu, Dong Shen
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Publication number: 20100228016Abstract: This invention provides a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases with improved catalytic activity and thermostability obtained by using recombinant techniques. These recombinant glucose isomerases comprise amino acid variation including phenylalanine (Phe) at position 139, alanine (Ala) at position 182, serine (Ser) at position 187, and glutamine (Gln) at position 299, and carry at least one additional mutated amino acid at position 87, position 217, position 260 or position 276, and possess a higher catalytic activity than that of the wild-type when using D-glucose as substrate. These recombinant glucose isomerases can be used for direct production of high fructose corn syrup containing 55% [wt] or higher concentration of fructose.Type: ApplicationFiled: March 15, 2010Publication date: September 9, 2010Applicant: GENEHARBOR (HK) TECHNOLOGIES LTD.Inventors: Jun Wang, Caike Jin, Rongzhao Fu, Dong Shen
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Patent number: 7704719Abstract: This invention provides a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases with improved catalytic activity and thermostability obtained by using recombinant techniques. These recombinant glucose isomerases comprise amino acid variation including phenylalanine (Phe) at position 139, alanine (Ala) at position 182, serine (Ser) at position 187, and glutamine (Gln) at position 299, and carry at least one additional mutated amino acid at position 87, position 217, position 260 or position 276, and possess a higher catalytic activity than that of the wild-type when using D-glucose as substrate. These recombinant glucose isomerases can be used for direct production of high fructose corn syrup containing 55.% [wt] or higher concentration of fructose.Type: GrantFiled: October 30, 2006Date of Patent: April 27, 2010Assignee: GeneHarbor (HK) Technologies Ltd.Inventors: Jun Wang, Caike Jin, Rongzhao Fu, Dong Shen
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Publication number: 20100028971Abstract: The invention discloses a carrier made from an organic foam having open pores for enzymes or cells immobilization and the methods for preparing immobilized enzymes or cells. The invention uses flocculation and crosslinking technology to immobilize enzyme protein or cells on the organic foam material having open pores. The resultant immobilized products have larger specific surface area, higher specific activity and can be made into various shapes.Type: ApplicationFiled: September 25, 2006Publication date: February 4, 2010Applicant: GENEHARBOR (HONG KONG) TECHNOLOGIES LTD.Inventors: Caike Jin, Jun Wang
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Publication number: 20080305529Abstract: This invention provides a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases with improved catalytic activity and thermostability obtained by using recombinant techniques. These recombinant glucose isomerases comprise amino acid variation including phenylalanine Phe) at position 139, alanine (Ala) at position 182, serine (Ser) at position 187, and glutamine (Gln) at position 299, and carry at least one additional mutated amino acid at position 87, position 217, position 260 or position 276, and possess a higher catalytic activity than that of the wild-type when using D-glucose as substrate. These recombinant glucose isomerases can be used for direct production of high fructose corn syrup containing 55.% [wt] or higher concentration of fructose.Type: ApplicationFiled: October 30, 2006Publication date: December 11, 2008Applicant: GENEHARBOR (HK) TECHNOLOGIES LTD.Inventors: Jun Wang, Caike Jin, Rongzhao Fu, Dong Shen
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Publication number: 20080113415Abstract: This invention describes a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases having improved catalytic activity and thermostability. The recombinant glucose isomerases can be used for direct production of fructose syrup containing 55 wt % or higher concentration of fructose, or used for the production of fructose syrup containing less than 55 wt % fructose.Type: ApplicationFiled: July 28, 2004Publication date: May 15, 2008Inventors: Jun Wang, Pongzhao Fu, Dorg Shen, Caike Jin, Zhangming Liu, Junming Chen