Patents by Inventor Caili SUN

Caili SUN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Construction of accumulating strain and industrial application of constructed strain
    Patent number: 11479778
    Abstract: The present invention relates to the technical field of gene engineering and particularly relates to a method for constructing non-de novo synthesized Mucor circinelloides recombinant strain with high lipid yield, recombinant strain constructed by method, and application of recombinant strain. According to the present invention, a diacylglycerol acyltransferase gene (DGAT) is overexpressed in Mucor circinelloides WJ11 by a homologous recombination technology, and exogenous oil is added for fermentation, such that the non-de novo synthesized Mucor circinelloides recombinant strain with high lipid yield is constructed. Compared with the control strain Mc2075, the fat yield of the Mucor circinelloides is increased; and when the diacylglycerol acyltransferase (DGAT) is transformed into the uracil defective type of Mucor circinelloides WJ11, the fatty acid composition changes after fermentation, and the lipid content may reach 53% of dry cell weight after the fermentation condition is optimized.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: October 25, 2022
    Assignee: SHANDONG UNIVERSITY OF TECHNOLOGY
    Inventors: Yuanda Song, Caili Sun, Huaiyuan Zhang, Wu Yang, Meiling Chen
  • CONSTRUCTION OF HIGH LIPID ACCUMULATING MUCOR CIRCINELLOIDES STRAIN BY NON-DE NOVO SYNTHESIS METHOD AND INDUSTRIAL APPLICATION OF CONSTRUCTED STRAIN
    Publication number: 20220186237
    Abstract: The present invention relates to the technical field of gene engineering and particularly relates to a method for constructing non-de novo synthesized Mucor circinelloides recombinant strain with high lipid yield, recombinant strain constructed by method, and application of recombinant strain. According to the present invention, a diacylglycerol acyltransferase gene (DGAT) is overexpressed in Mucor circinelloides WJ11 by a homologous recombination technology, and exogenous oil is added for fermentation, such that the non-de novo synthesized Mucor circinelloides recombinant strain with high lipid yield is constructed. Compared with the control strain Mc2075, the fat yield of the Mucor circinelloides is increased; and when the diacylglycerol acyltransferase (DGAT) is transformed into the uracil defective type of Mucor circinelloides WJ11, the fatty acid composition changes after fermentation, and the lipid content may reach 53% of dry cell weight after the fermentation condition is optimized.
    Type: Application
    Filed: November 30, 2020
    Publication date: June 16, 2022
    Inventors: Yuanda SONG, Caili SUN, Huaiyuan ZHANG, Wu YANG, Meiling CHEN