Patents by Inventor Caili Wang

Caili Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11158475
    Abstract: The subject matter discloses a relay, including a housing, static contact bridges, a moving contact bridge, a pushing mechanism and a detection assembly.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: October 26, 2021
    Assignee: BYD COMPANY LIMITED
    Inventors: Baotong Yao, Caili Huang, Siyuan Liu, Lujian Wang
  • Patent number: 10865152
    Abstract: A polycrystalline diamond compact including a cemented carbide substrate and a polycrystalline diamond layer bonded to the cemented carbide substrate. The cemented carbide substrate is cylindrical and includes a circumferential wall. The polycrystalline diamond layer includes a central part including between 8 and 15 wt. % of cobalt and an outer part including between 0.5 and 2 wt. % of cobalt. The outer part is a columnar ring belt and includes a chamfer. The outer part includes an upper surface, a side surface connected to the circumferential wall of the cemented carbide substrate, and a chamfer surface connecting the upper surface and the side surface. The chamfer includes a first terminal connected to the upper surface of the outer part and a second terminal connected to the side surface of the outer part.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: December 15, 2020
    Assignee: SF DIAMOND CO., LTD.
    Inventors: Caili Wang, Dongpeng Zhao, Saifei Yang, Haijiang Fang
  • Publication number: 20190210931
    Abstract: A polycrystalline diamond compact including a cemented carbide substrate and a polycrystalline diamond layer bonded to the cemented carbide substrate. The cemented carbide substrate is cylindrical and includes a circumferential wall. The polycrystalline diamond layer includes a central part including between 8 and 15 wt. % of cobalt and an outer part including between 0.5 and 2 wt. % of cobalt. The outer part is a columnar ring belt and includes a chamfer. The outer part includes an upper surface, a side surface connected to the circumferential wall of the cemented carbide substrate, and a chamfer surface connecting the upper surface and the side surface. The chamfer includes a first terminal connected to the upper surface of the outer part and a second terminal connected to the side surface of the outer part.
    Type: Application
    Filed: March 14, 2019
    Publication date: July 11, 2019
    Inventors: Caili WANG, Dongpeng ZHAO, Saifei YANG, Haijiang FANG
  • Patent number: 8802827
    Abstract: Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: August 12, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Peter Peizhi Luo, Kevin Caili Wang, Pingyu Zhong, Mark Hsieh, Yan Li, Xinwei Wang, Feng Dong, Andrei Golosov, Yan Ni, Weirong Wang, Laurence B. Peterson, Rose Cubbon
  • Publication number: 20140121123
    Abstract: The invention provides methods of introducing diversity into antibody molecules comprising introducing or substituting at least one amino acid sequence in the CDR of the target antibody together with at least one amino acid in the FW region spanning the 3 amino acid adjoining the CRD on each side. The resulting diverse antibodies with variant CDRs and FW region sequences comprising diverse amino acid sequences are also described. These polypeptides regions, herein referred to as 3+CDR3+, that form the gist of the invention contribution described herein provide a flexible and simple source of sequence diversity that can be used as a source for expressing and identifying diverse antibodies or antigen binding polypeptides. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.
    Type: Application
    Filed: October 24, 2011
    Publication date: May 1, 2014
    Inventors: Kevin Caili Wang, Yan Li, Mark Hsieh, Xinwei Wang, Xinwei Wang, Feng Dong, Peizhi (Peter) Luo, Pingyu Zhong
  • Patent number: 8637435
    Abstract: The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells.
    Type: Grant
    Filed: November 14, 2008
    Date of Patent: January 28, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Kevin Caili Wang, Peter Peizhi Luo, Pingyu Zhong, Jian Wang
  • Publication number: 20120329679
    Abstract: The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells.
    Type: Application
    Filed: March 23, 2012
    Publication date: December 27, 2012
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Kevin Caili Wang, Peter Peizhi Luo, Pingyu Zhong, Jian Wang
  • Publication number: 20120231005
    Abstract: Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
    Type: Application
    Filed: October 29, 2010
    Publication date: September 13, 2012
    Inventors: Peter Peizhi Luo, Kevin Caili Wang, Pingyu Zhong, Mark Hsieh, Yan Li, Xinwei Wang, Feng Dong, Andrei Golosov, Yan Ni, Weirong Wang, Laurence B. Peterson, Rose Cubbon
  • Publication number: 20120129702
    Abstract: The present invention provides a structure-based methodology for efficiently generating and screening a library of recombinant antibodies for optimized antibodies with desirable functions, such as higher binding affinity or low immunogenicity. In one embodiment, a method is provided for constructing a library of antibody sequences based on a three dimensional structure of a lead antibody. The method comprises: providing a lead structural template comprising the amino acid sequence of the variable region of the heavy chain (VH) or light chain (VL) of a lead antibody, comparing the lead template sequence with a plurality of tester protein sequences; selecting a hit library from the tester protein sequences; determining if a member of the hit library is structurally compatible with the lead structural template using a scoring function; selecting members for the hit library that score equal to or better than the lead sequence and screening members for improved function(s).
    Type: Application
    Filed: October 28, 2010
    Publication date: May 24, 2012
    Inventors: Peizhi Luo, Mark Hsieh, Pingyu Zhong, Caili Wang
  • Patent number: 8030469
    Abstract: The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: October 4, 2011
    Assignee: SBI Incubation Co., Ltd.
    Inventors: Teikichi Aoyagi, Peter Peizhi Luo, Pingyu Zhong, Mark Hsieh, Yan Li, Kevin Caili Wang, Chikao Morimoto
  • Publication number: 20110171729
    Abstract: The invention provides a novel method for generating stable mammalian cell lines with enhanced protein production capabilities, and to expression vectors and related methods for high level expression of biopharmaceutical proteins of interest.
    Type: Application
    Filed: May 3, 2007
    Publication date: July 14, 2011
    Applicant: AB MAXIS INC.
    Inventors: Kevin Caili Wang, Shengjiang Kiu
  • Publication number: 20110124528
    Abstract: The present invention provides a methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as improved binding affinity towards biologically and/or therapeutically important target molecules. The process is carried out computationally in a high throughput manner by mining the ever-expanding databases of protein sequences of all organisms, especially human.
    Type: Application
    Filed: October 29, 2010
    Publication date: May 26, 2011
    Inventors: Peizhi Luo, Mark Hsieh, Pingyu Zhong, Caili Wang, Yicheng Cao, Shengjiang Liu
  • Patent number: 7910350
    Abstract: The present invention provides adapter-directed display systems for expressing exogenous polypeptide within a host cell and/or displaying the exogenous polypeptide on the outer surface of a genetic package. This subject systems are particularly useful for displaying a genetically diverse repertoire of monomeric and multimeric polypeptides. The invention also provides both expression and helper vectors and kits containing components of the subject display systems. Also provided are genetic packages displaying the exogenous polypeptides of particular interest. Further provided by the invention are methods of using the subject display systems.
    Type: Grant
    Filed: December 19, 2005
    Date of Patent: March 22, 2011
    Assignee: Abmaxis, Inc.
    Inventors: Caili Wang, Pingyu Zhong, Xinwei Wang
  • Publication number: 20090163379
    Abstract: The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells.
    Type: Application
    Filed: November 14, 2008
    Publication date: June 25, 2009
    Inventors: Kevin Caili Wang, Peter Peizhi Luo, Pingyu Zhong, Jian Wang
  • Publication number: 20090136523
    Abstract: The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided.
    Type: Application
    Filed: November 3, 2008
    Publication date: May 28, 2009
    Applicant: Y's Therapeutics Co, Ltd.
    Inventors: Teikichi Aoyagi, Peter Peizhi Luo, Pingyu Zhong, Mark Hsieh, Yan Li, Kevin Caili Wang, Chikao Morimoto
  • Publication number: 20090082221
    Abstract: The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for multi-species and cross-species display of polypeptides on the outer surface of prokaryotic genetic packages and/or eukaryotic host cells. The multi-species and cross-species display systems can be practiced using the vector sets of the invention without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of phage, bacterial host cells, yeast cells, and mammalian cells.
    Type: Application
    Filed: May 3, 2007
    Publication date: March 26, 2009
    Inventors: Kevin Caili Wang, Pingyu Zhong, Peter Peizhi Luo
  • Patent number: 7462698
    Abstract: The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided.
    Type: Grant
    Filed: July 24, 2006
    Date of Patent: December 9, 2008
    Assignee: Y's Therapeutics Co., Ltd.
    Inventors: Teikichi Aoyagi, Peter Peizhi Luo, Pingyu Zhong, Mark Hsieh, Yan Li, Kevin Caili Wang, Chikao Morimoto
  • Patent number: 7429652
    Abstract: The present invention provides a technique for specific assembly of monomeric polypeptides to form a heteromultimer. This technique is particularly useful for generating a genetically diverse repertoire of heteromultimers such as antigen-binding units. The invention also provides both non-single-chain and single-chain antigen-binding units that are assembled by the technique described herein. The present invention also provides recombinant polynucleotides, vectors, host cells, and kits for producing the subject antigen-binding units. Further provided by the invention are methods of using the subject antigen-binding units.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: September 30, 2008
    Assignee: Abmaxis, Inc.
    Inventors: Caili Wang, Pingyu Zhong, Shengjiang Liu, Peizhi Luo, Shengfeng Li, Xinwei Wang
  • Publication number: 20070037214
    Abstract: The present invention provides a methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as improved binding affinity towards biologically and/or therapeutically important target molecules. The process is carried out computationally in a high throughput manner by mining the ever-expanding databases of protein sequences of all organisms, especially human.
    Type: Application
    Filed: August 10, 2006
    Publication date: February 15, 2007
    Inventors: Peizhi Luo, Mark Hsieh, Pingyu Zhong, Caili Wang, Yicheng Cao, Shengjiang Liu
  • Publication number: 20070037217
    Abstract: The present invention provides a structure-based methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as antibodies with high binding affinity and low immunogenicity in humans. In one embodiment, a method is provided for constructing a library of antibody sequences based on a three dimensional structure of a lead antibody.
    Type: Application
    Filed: August 17, 2006
    Publication date: February 15, 2007
    Inventors: Peizhi Luo, Mark Hsieh, Pingyu Zhong, Caili Wang