Patents by Inventor Cailin Chen

Cailin Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist
    Patent number: 8673890
    Abstract: The present invention is directed to novel 2,3-dihydro-1H-isoindol-1-imine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the thrombin PAR-1 receptor antagonists.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: March 18, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Kimberly White, Stephen C. Yabut, Hong Ye, Cailin Chen
  • Substituted [1,2,3] triazolo[4,5-d]pyrimidine derivatives as ADP P2Yreceptor antagonists
    Patent number: 8148385
    Abstract: The present invention is directed to novel bicyclic triazolopyrimidine compounds of Formula (I) or a form thereof: wherein X1, X2, R1, R2, R3 and R4 are as defined herein, and their methods of preparation and use as ADP inhibitors.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: April 3, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye, Cailin Chen
  • 2,3-DIHYDRO-1H-ISOINDOL-1-IMINE DERIVATIVES USEFUL AS THROMBIN PAR-1 RECEPTOR ANTAGONIST
    Publication number: 20110105490
    Abstract: The present invention is directed to novel 2,3-dihydro-1H-isoindol-1-imine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the thrombin PAR-1 receptor antagonists.
    Type: Application
    Filed: October 28, 2010
    Publication date: May 5, 2011
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Kimberly White, Stephen C. Yabut, Hong Ye, Cailin Chen
  • Triazolopyrimidine derivatives as ADP P2Yreceptor antagonists
    Patent number: 7566722
    Abstract: The present invention is directed to novel bicyclic triazolopyrimidine compounds of Formula (I) or a form thereof: wherein R1 and R2 are as defined herein, and their methods of preparation and use as ADP inhibitors.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: July 28, 2009
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye, Cailin Chen
  • Triazolopyrimidine derivatives as ADP P2Y12 receptor antagonists
    Publication number: 20080312257
    Abstract: The present invention is directed to novel bicyclic triazolopyrimidine compounds of Formula (I) or a form thereof: wherein X1, X2, R1, R2, R3 and R4 are as defined herein, and their methods of preparation and use as ADP inhibitors.
    Type: Application
    Filed: October 31, 2007
    Publication date: December 18, 2008
    Inventors: Han-Cheng Zhang, Bruce E. Maryanoff, Hong Ye, Cailin Chen
  • Human PRSS11-like S2 serine protease and uses thereof
    Patent number: 7452708
    Abstract: A novel human cDNA, termed PRSS11-L, was isolated which encodes a polypeptide that belongs to the S2/HtrA serine protease family. The PRSS11-L mRNA is widely expressed in several tissues throughout the body by multi-tissue Northern blotting. The full-length PRSS11-L cDNA, was cloned, expressed and purified. Proteolytic activity was demonstrated using the protein substrate casein. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.
    Type: Grant
    Filed: September 7, 2006
    Date of Patent: November 18, 2008
    Assignee: Ortho-Mcneil Pharmaceutical, Inc.
    Inventors: Andrew Lawrence Darrow, Jian-Shen Qi, Cailin Chen, Patricia Andrade-Gordon
  • Triazolopyrimidine derivatives as ADP P2Y12 receptor antagonists
    Publication number: 20080108635
    Abstract: The present invention is directed to novel bicyclic triazolopyrimidine compounds of Formula (I) or a form thereof: wherein R1 and R2 are as defined herein, and their methods of preparation and use as ADP inhibitors.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 8, 2008
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, Hong Ye, Cailin Chen
  • Human PRSS11-like S2 serine protease and uses thereof
    Publication number: 20070065897
    Abstract: A novel human cDNA, termed PRSS11-L, was isolated which encodes a polypeptide that belongs to the S2/HtrA serine protease family. The PRSS11-L mRNA is widely expressed in several tissues throughout the body by multi-tissue Northern blotting. The full-length PRSS11-L cDNA, was cloned, expressed and purified. Proteolytic activity was demonstrated using the protein substrate casein. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.
    Type: Application
    Filed: September 7, 2006
    Publication date: March 22, 2007
    Inventors: Andrew Darrow, Jian-shen Qi, Cailin Chen, Patricia Andrade-Gordon
  • Human PRSS11-Like S2 serine protease and uses thereof
    Patent number: 7132523
    Abstract: A novel human nucleic acid and polypeptide, termed PRSS11-L, are disclosed. PRSS11-L, which is observed in tissues throughout the body, can be used in methods of detection, gene therapy, and screening.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: November 7, 2006
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Andrew Lawrence Darrow, Jian-shen Qi, Cailin Chen, Patricia Andrade-Gordon
  • Human PRSS11-Like S2 serine protease and uses thereof
    Publication number: 20050019777
    Abstract: A novel human cDNA, termed PRSS11-L, was isolated which encodes a polypeptide that belongs to the S2/HtrA serine protease family. The PRSS11-L mRNA is widely expressed in several tissues throughout the body by multi-tissue Northern blotting. The full-length PRSS11-L cDNA, was cloned, expressed and purified. Proteolytic activity was demonstrated using the protein substrate casein. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.
    Type: Application
    Filed: July 2, 2003
    Publication date: January 27, 2005
    Inventors: Andrew Darrow, Jian-shen Qi, Cailin Chen, Patricia Andrade-Gordon
  • Epitope-tagged recombinant Growth Arrest Specific Gene 6 protein
    Publication number: 20040157774
    Abstract: The present invention provides epitope-tagged mammalian recombinant Growth Arrest Specific Gene 6 (Gas6) proteins or polypeptides that retain their biological activity of Gas6, including a novel method of generating and purifying the aforesaid proteins or polypeptides. Such biolgically active eptitope-tagged Gas6 proteins or polypeptides can be used when the presence of Gas6 is required and/or when Gas6 antagonists and receptors need to be identified. Prior to being expressed from a mammalian cell, the recombinant Gas6 protein or polypeptide is tagged with either Flag or polyhistidine to the C-terminus. After expression, the protein or polypeptide is purified in a single step affinity purification using either anti-Flag antibody resin or nickle resin. The purified epitope-tagged mammalian recombinant Gas6 protein or polypeptide maintains its biological activity and can be used thereafter.
    Type: Application
    Filed: September 24, 2003
    Publication date: August 12, 2004
    Inventors: Jing Yang, Cailin Chen, Bing Hu, Patricia Andrade-Gordon, Robert Jordan
  • Human PRSS11-like S2 serine protease and uses thereof
    Publication number: 20040005659
    Abstract: A novel human cDNA, termed PRSS11-L, was isolated which encodes a polypeptide that belongs to the S2/HtrA serine protease family. The PRSS11-L mRNA is widely expressed in several tissues throughout the body by multi-tissue Northern blotting. The full-length PRSS11-L cDNA, was cloned, expressed and purified. Proteolytic activity was demonstrated using the protein substrate casein. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.
    Type: Application
    Filed: July 3, 2002
    Publication date: January 8, 2004
    Inventors: Andrew Lawrence Darrow, Jian-Shen Ql, Cailin Chen, Patricia Andrade-Gordon