Abstract: Presented herein are devices, systems, and methods related to liquid infused substrates for use in medical applications. Adhesion of proteins, pathogens, and other substances to medical devices presents an issue. Proteins from the surrounding environment adhere to medical devices, which may, under certain conditions, result in the adhesion of pathogens to the medical device. The presence of these pathogens may result in infections when a medical device is inserted or otherwise placed in vivo (in whole or in part), which may require the removal of the device and/or treatment of the subject with antibiotics. Changing the surface properties of such devices can alter which proteins, pathogens, and/or other substances adhere and/or adsorb to the surface. Accordingly, in some embodiments, the present disclosure provides for technologies for altering surface adhesion and/or absorption of proteins, pathogens and/or other substances by infusing/impregnating a substrate of the device with an impregnation fluid.

Abstract: A liquid infused membrane includes a porous fluorine-containing polymer membrane and a perfluoropolyether oil coating on at least a portion of the first surface and at least a portion of the pore wall. Advantageously, the liquid infused membrane does not exhibit gating. Methods for the manufacture thereof and uses of the liquid infused membrane are also disclosed.