Patents by Inventor Caius G. Radu

Caius G. Radu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THIOSEMICARBAZONE COMPOUNDS AND USES THEREOF
    Publication number: 20220274929
    Abstract: Provided, inter alia, are thiosemicarbazone compounds, metal complexes of thiosemicarbazone compounds, pharmaceutical compositions, and methods for treating cancer.
    Type: Application
    Filed: February 21, 2020
    Publication date: September 1, 2022
    Inventors: Caius G. Radu, Michael E. Jung, Daniel Sun, Nagichettiar Satyamurthy, Juno Van Valkenburgh, Roy Pan, Soumya Poddar
  • Deoxycytidine kinase binding compounds
    Patent number: 10570124
    Abstract: There are provided, inter alia, compounds useful for binding to deoxycytidine kinase, and compounds and methods useful to modulate deoxycytidine kinase.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: February 25, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Caius G. Radu, Raymond M. Gipson
  • DEOXYCYTIDINE KINASE BINDING COMPOUNDS
    Publication number: 20190016714
    Abstract: There are provided, inter alia, compounds useful for binding to deoxycytidine kinase, and compounds and methods useful to modulate deoxycytidine kinase.
    Type: Application
    Filed: January 9, 2017
    Publication date: January 17, 2019
    Inventors: Caius G. RADU, Raymond M. GIPSON
  • Deoxycytidine kinase inhibitors
    Patent number: 9981961
    Abstract: Provided herein are compounds that bind to dCK and methods for treating cancer.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: May 29, 2018
    Assignees: The Regents of the University of California, The Board of Trustees of the University of Illinois
    Inventors: Caius G. Radu, Zheng Li, Raymond M. Gipson, Jue Wang, Nagichettiar Satyamurthy, Arnon Lavie, Jennifer M. Murphy, David A. Nathanson, Michael E. Jung
  • Supramolecular approach for preparation of size controllable nanoparticles
    Patent number: 9845237
    Abstract: A supramolecular approach has been developed for preparation of size-controllable nanoparticles, from three different molecular building blocks.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: December 19, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Hsian-Rong Tseng, Hao Wang, Shutao Wang, Helen Su, Caius G. Radu, Johannes Czernin
  • DEOXYCYTIDINE KINASE INHIBITORS
    Publication number: 20170204090
    Abstract: Provided herein are compounds that bind to dCK and methods for treating cancer.
    Type: Application
    Filed: January 31, 2017
    Publication date: July 20, 2017
    Inventors: CAIUS G. RADU, ZHENG LI, RAYMOND M. GIPSON, JUE WANG, NAGICHETTIAR SATYAMURTHY, ARNON LAVIE, JENNIFER M. MURPHY, DAVID A. NATHANSON, MICHAEL E. JUNG
  • Deoxycytidine kinase binding compounds
    Patent number: 9688673
    Abstract: The invention provides compounds that bind to deoxycytidine kinase (dCK) and compositions including pharmaceutically acceptable compositions containing the compounds. The compounds are useful in treating diseases and disorders where dCK activity is implicated such as cancer and immune disorders. The compounds also find use in clinical methodologies including positron emission tomography (PET) imaging.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: June 27, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Caius G. Radu, Hsiang-I Liao, Nagichettiar Satyamurthy, Johannes Czernin, Jennifer M. Murphy, David A. Nathanson
  • Deoxycytidine kinase inhibitors
    Patent number: 9598404
    Abstract: Provided herein are compounds that bind to dCK and methods for treating cancer.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: March 21, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Caius G. Radu, Zheng Li, Raymond M. Gipson, Jue Wang, Nagichettiar Satyamurthy, Arnon Lavie, Jennifer M. Murphy, David A. Nathanson, Michael E. Jung
  • DEOXYCYTIDINE KINASE INHIBITORS
    Publication number: 20160237076
    Abstract: Provided herein are compounds that bind to dCK and methods for treating cancer.
    Type: Application
    Filed: January 11, 2016
    Publication date: August 18, 2016
    Inventors: Caius G. Radu, Zheng Li, Raymond M. Gipson, Jue Wang, Nagichettiar Satyamurthy, Arnon Lavie, Jennifer M. Murphy, David A. Nathanson, Michael E. Jung
  • NON-IMMUNOGENIC POSITRON EMISSION TOMOGRAPHY REPORTER GENE SYSTEMS
    Publication number: 20140248212
    Abstract: Embodiments of the invention include a PET/SPECT reporter gene system that uses enhanced non-immunogenic versions of a human mitochondrial thymidine kinase 2 expressed in cytoplasm to preferentially trap novel PET/SPECT radiolabeled L and D-enantiomer analogs of the natural substrate thymidine. Such highly sensitive, non-immunogenic reporter genes function in combination with a set of novel, radiolabeled probes in whole body molecular imaging applications using positron emission tomography (PET) or single photon emission computed tomography (SPECT).
    Type: Application
    Filed: August 6, 2012
    Publication date: September 4, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Caius G. Radu, Johannes Czernin, Dean O. Campbell, Shahriar S. Yaghoubi, Nagichettiar Satyamurthy, Arnon Lavie
  • DEOXYCYTIDINE KINASE BINDING COMPOUNDS
    Publication number: 20130336883
    Abstract: The invention provides compounds that bind to deoxycytidine kinase (dCK) and compositions including pharmaceutically acceptable compositions containing the compounds. The compounds are useful in treating diseases and disorders where dCK activity is implicated such as cancer and immune disorders. The compounds also find use in clinical methodologies including positron emission tomography (PET) imaging.
    Type: Application
    Filed: March 8, 2012
    Publication date: December 19, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Caius G. Radu, Hsiang-I Liao, Nagichettiar Satyamurthy, Johannes Czernin, Jennifer M. Murphy, David A. Nathanson
  • Capture agents and related methods and systems for detecting and/or sorting targets
    Patent number: 8394590
    Abstract: Polynucleotide-encoded capture agents for target detection and in particular modular polynucleotide-capture agents comprising a target binding component, a scaffold component and an encoding component formed by standardized molecular units that can be coupled and decoupled in a controlled fashion, and related compositions methods and systems.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: March 12, 2013
    Assignees: California Institute of Technology, University of California
    Inventors: Gabriel A. Kwong, Caius G. Radu, Owen Witte, James R. Heath, Antoni Ribas
  • Positron emission tomography probes for imaging immune activation and selected cancers
    Patent number: 8101740
    Abstract: Compounds for use as PET probes and methods for synthesizing and using these, comprising [18F]D-FAC and other cytosine and adenosine analogs.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: January 24, 2012
    Assignee: The Regents of the University of California
    Inventors: Caius G. Radu, Owen N. Witte, Evan David Nair-Gill, Nagichettiar Satyamurthy, Chengyi J. Shu, Johannes Czernin
  • SUPRAMOLECULAR APPROACH FOR PREPARATION OF SIZE CONTROLLABLE NANOPARTICLES
    Publication number: 20110305685
    Abstract: A supramolecular approach has been developed for preparation of size-controllable nanoparticles, from three different molecular building blocks.
    Type: Application
    Filed: February 26, 2010
    Publication date: December 15, 2011
    Applicant: The Regents of the University of California
    Inventors: Hsian-Rong Tseng, Hao Wang, Shutao Wang, Helen Su, Caius G. Radu, Johannes Czernin
  • CAPTURE AGENTS AND RELATED METHODS AND SYSTEMS FOR DETECTING AND/OR SORTING TARGETS
    Publication number: 20110166034
    Abstract: Polynucleotide-encoded capture agents for target detection and in particular modular polynucleotide-capture agents comprising a target binding component, a scaffold component and an encoding component formed by standardized molecular units that can be coupled and decoupled in a controlled fashion, and related compositions methods and systems.
    Type: Application
    Filed: October 8, 2010
    Publication date: July 7, 2011
    Inventors: Gabriel A. Kwong, Caius G. Radu, Owen Witte, James R. Heath, Antoni Ribas
  • POSITRON EMISSION TOMOGRAPHY PROBES FOR IMAGING IMMUNE ACTIVATION AND SELECTED CANCERS
    Publication number: 20090105184
    Abstract: Compounds for use as PET probes and methods for synthesizing and using these, comprising [18F]D-FAC and other cytosine and adenosine analogs.
    Type: Application
    Filed: September 19, 2008
    Publication date: April 23, 2009
    Applicant: The Regents of the University of California
    Inventors: Caius G. Radu, Owen N. Witte, Evan David Nair-Gill, Nagichettiar Satyamurthy, Chengyi J. Shu, Johannes Czernin