Abstract: Provided is the use of a CSF1R kinase inhibitor compound or a pharmaceutically acceptable salt thereof in the preparation of drugs for treating diseases related to the CSF1R kinase signal transduction pathway or drugs for regulating immunization.

Abstract: Use of a compound of general formula (A) which is a CFS-IR kinase inhibitor or a pharmaceutically acceptable salt thereof in the preparation of medicaments for treating diseases related to CSF-1R kinase signal transduction pathway or medicaments for regulating immunization. In vivo and in vitro studies show that the compound can significantly inhibit CSF-IR kinase activity; significantly inhibits the proliferation of a CSF-1/CSF-1R-driven mouse myeloid leukemia cell line, inhibits the survival of macrophages induced by CSF-1 and reverses M2 polarization phenotype of macrophages, and has an effect superior to that of the marketed medicament Pexidartinib. In a TAM enriched tumor model (MC38 model), the compound significantly antagonizes the tumor immunosuppressive microenvironment and exhibits significant anti-tumor efficacy.

Abstract: A method for determining the usage amount of detergent, and a dishwasher, a processor, a storage medium and a computer program product. The method for determining the usage amount of detergent includes acquiring an internal image of a dishwasher captured by an image acquisition device; according to the internal image, determining whether there is a target object in the dishwasher; when it is determined that there is a target object, generating a position table of the target object; determining the dirtiness of the target object according to the position table; and determining the usage amount of detergent for the dishwasher according to the dirtiness. The dirtiness of a target object needing to be cleaned in a dishwasher is determined by means of an image acquisition device, and the usage amount of detergent for the dishwasher is then determined according to the dirtiness.

Abstract: A use of oleanolic acid-28-O-?-D-glucopyranoside in the preparation of an anti-colitis drug is provided. The oleanolic acid-28-O-?-D-glucopyranoside has significant anti-ulcerative-colitis activity compared with parent nucleus oleanolic acid and other analogues, and has equivalent efficacy compared with Mesalazine, a first-line drug for the clinical treatment of inflammatory bowel disease, and can also avoid salicylic acid anaphylaxis possibly caused by Mesalazine western medicine treatment, thereby achieving a good application prospect.

Abstract: A nanoparticle composition for rapid suspension and a preparation method therefor. The composition comprises an active ingredient, albumin and a particle stabilizer, and optionally a lyoprotectant. The active ingredient has the following characteristics: insoluble or slightly soluble in water, and soluble or easily soluble in specific organic solvents, and is preferably paclitaxel or docetaxel.

Abstract: A use of oleanolic acid-28-O-?-D-glucopyranoside in the preparation of an anti-colitis drug is provided. The oleanolic acid-28-O-?-D-glucopyranoside has significant anti-ulcerative-colitis activity compared with parent nucleus oleanolic acid and other analogues, and has equivalent efficacy compared with Mesalazine, a first-line drug for the clinical treatment of inflammatory bowel disease, and can also avoid salicylic acid anaphylaxis possibly caused by Mesalazine western medicine treatment, thereby achieving a good application prospect.

Abstract: A soil regulation and control device for preventing grassland soil degradation is provided, and relates to the field of grassland restoration. The soil regulation and control device includes a vehicle body arranged in a horizontal state; a reaction cylinder fixedly arranged above the vehicle body and accommodating fertilizer and water; a mixing and stirring mechanism connected with the reaction cylinder and fully mixing the fertilizer and water in the reaction cylinder a reciprocating water spraying mechanism arranged at a lower end of the mixing and stirring mechanism and spraying uniformly mixed fertilizer and water; and a loosening and sowing assembly including a reciprocating soil loosening mechanism connected with the reciprocating water spraying mechanism and loosening soil, and a vibrating sowing mechanism connected with the reciprocating soil loosening mechanism and scattering grass seeds on the loosened soil.

Abstract: Mitoxantrone hydrochloride liposome can be used in the preparation of drugs for treating advanced solid tumors. A higher therapeutically effective amount of mitoxantrone hydrochloride liposome, for example 8-150 mg/m2, is administered to patients with the advanced solid tumors. Animal test results show that the mitoxantrone hydrochloride liposome can effectively inhibit the growth of various solid tumor transplantation tumors. Clinical research results show that the mitoxantrone hydrochloride liposome can effectively treat advanced solid tumors, and is safe and controllable.

Abstract: A soil regulation and control device for preventing grassland soil degradation is provided, and relates to the field of grassland restoration. The soil regulation and control device includes a vehicle body arranged in a horizontal state; a reaction cylinder fixedly arranged above the vehicle body and accommodating fertilizer and water; a mixing and stirring mechanism connected with the reaction cylinder and fully mixing the fertilizer and water in the reaction cylinder a reciprocating water spraying mechanism arranged at a lower end of the mixing and stirring mechanism and spraying uniformly mixed fertilizer and water; and a loosening and sowing assembly including a reciprocating soil loosening mechanism connected with the reciprocating water spraying mechanism and loosening soil, and a vibrating sowing mechanism connected with the reciprocating soil loosening mechanism and scattering grass seeds on the loosened soil.

Abstract: A virulence factor FsPL gene from the sugarcane pokkah boeng disease and use thereof are provided. The virulence factor FsPL gene from the sugarcane pokkah boeng disease has a sequence set forth in SEQ ID NO: 1. The present invention reveals a gene FsPL that is related to the pathogenicity of F. sacchari. Preliminary analysis shows that the deletion of the gene affects the ability of hyphae to penetrate and further affects the pathogenicity of pathogens. This provides a basis for the molecular mechanism of the pathogen infection and pathogenic process.

Abstract: The present application provides a use of mitoxantrone hydrochloride liposome in the preparation of a medicament for treating ovarian cancer, gastric cancer or head and neck squamous cell carcinoma, a method for treating ovarian cancer, gastric cancer or head and neck squamous cell carcinoma using a mitoxantrone hydrochloride liposome formulation, and a mitoxantrone hydrochloride liposome formulation for treating ovarian cancer, gastric cancer or head and neck squamous cell carcinoma.

Abstract: A method for determining the usage amount of detergent, and a dishwasher, a processor, a storage medium and a computer program product. The method for determining the usage amount of detergent includes acquiring an internal image of a dishwasher captured by an image acquisition device; according to the internal image, determining whether there is a target object in the dishwasher; when it is determined that there is a target object, generating a position table of the target object; determining the dirtiness of the target object according to the position table; and determining the usage amount of detergent for the dishwasher according to the dirtiness. The dirtiness of a target object needing to be cleaned in a dishwasher is determined by means of an image acquisition device, and the usage amount of detergent for the dishwasher is then determined according to the dirtiness.

Abstract: Provided is the use of a CSF1R kinase inhibitor compound or a pharmaceutically acceptable salt thereof in the preparation of drugs for treating diseases related to the CSF1R kinase signal transduction pathway or drugs for regulating immunization.

Abstract: A cleaning method and cleaning apparatus for a dishwasher, and a dishwasher. The cleaning method for a dishwasher includes acquiring a first image of tableware in a dishwasher, identifying the type of dirt on the tableware according to the first image, determining a corresponding washing mode according to the type of dirt, controlling the dishwasher to successively clean the tableware according to the washing mode, each time after the cleaning is completed, acquiring a second image of the tableware in the dishwasher, and comparing the first image with the second image, to determine the effectiveness of the washing mode. In this way, the problem in the prior art of it being impossible to accurately identify the type of dirt can be solved, and an appropriate washing mode is matched for the current type of dirt, to realize thorough cleaning, and less time is consumed, the efficiency is high, and less water energy and electric energy are used.

Abstract: Use of a compound of general formula (A) which is a CFS-1R kinase inhibitor or a pharmaceutically acceptable salt thereof in the preparation of medicaments for treating diseases related to CSF-1R kinase signal transduction pathway or medicaments for regulating immunization. In vivo and in vitro studies show that the compound can significantly inhibit CSF-1R kinase activity; significantly inhibits the proliferation of a CSF-1/CSF-1R-driven mouse myeloid leukemia cell line, inhibits the survival of macrophages induced by CSF-1 and reverses M2 polarization phenotype of macrophages, and has an effect superior to that of the marketed medicament Pexidartinib. In a TAM enriched tumor model (MC38 model), the compound significantly antagonizes the tumor immunosuppressive microenvironment and exhibits significant anti-tumor efficacy.

Abstract: A natural edible shampoo and preparation method thereof, the components comprises fatty acyl lactyl-lactic acid, arginine, vegetable oleic acid monoglyceride, plant phospholipid, ?-polylysine, ethyl lauroyl arginate hydrochloride, inulin, polyol and so on. It resist static electricity, improve the smoothness of hair, prevent pore clogging, and has good flowability at a low temperature. The shampoo overturns the classic concept of existing cationic hair care (large irritation), uses nearly non-irritant natural anionic wash and care main ingredients, relies on a non-enclosed protein peptide/low HLB value oiliness agent film-forming smoothing system, avoids a cationic polymer/silicone oil hair-care pattern with intensive negative effect, and protects the original ecological environment of hair and scalp, so that a final product gains the smooth experience feeling of organic silicone oil, thereby creating a new path for research and development of food and cosmetic-type wash and care two-in-one shampoos.

Abstract: A liposome comprising bilayer and inner water phase is disclosed. Said inner water phase may contain sulfobutyl ether cyclodextrin and an active compound.

Abstract: The preset disclosure provides a driving circuit, a driving method, and a display panel including the driving circuit. The driving circuit includes a plurality of gate driver on array (GOA) unit circuits. Odd stages of the GOA unit circuits are cascaded with each other and even stages of the GOA unit circuits are cascaded with each other. Signal lines disposed and corresponding to the odd stages of the GOA unit circuits provide odd stage scan control signals, odd stage scan start signals, and odd stage high frequency clock signals. Signal lines disposed and corresponding to the even stages of the GOA unit circuits provide even stage scan control signals, even stage scan start signals, and even stage high frequency clock signals. A common line disposed and corresponding to all of the GOA unit circuits provides a first low frequency clock signal and a second low frequency clock signal.

Abstract: The invention belongs to the technical field of health food and particularly relates to a composition for relieving stress and enhancing immunity and a preparation method thereof. The composition for relieving stress and enhancing immunity is calculated in parts by weight, 100-300 parts of a radix curcuma extract, 100-250 parts of a sea cucumber extract, 100-250 parts of a chlorella extract, 50-150 parts of a cranberry extract, 100-300 parts of a ginseng extract, 80-150 parts of a coconut oil extract and 100-200 parts of a palm oil extract. The composition can significantly enhance the body's immunity, relieve mental stress and improve the level of human health. In addition, the composition of the present invention is suitable for long-term use and has a small adverse reaction.

Abstract: Purified therapeutic nanoparticles are provided herein. Such nanoparticles comprise an active pharmaceutical ingredient and human serum albumin, wherein the weight ratio of human serum albumin to the active ingredient in the therapeutic nanoparticles is from 0.01:1 to 1:1, and wherein the nanoparticles are substantially free of free human serum albumin that is not incorporated in the nanoparticles. The present disclosure also provides pharmaceutical compositions that comprise the purified therapeutic nanoparticles and are also substantially free of free human serum albumin. Methods for preparing and using the purified therapeutic nanoparticles and compositions thereof are also provided.