Patents by Inventor Cale Halbleib

Cale Halbleib has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC ANTIBODIES BASED ON MUTATED IGG HEXAMERS
    Publication number: 20200247897
    Abstract: The present invention relates to formulation of antibodies. The invention relates in particular to pharmaceutical compositions comprising an antibody molecule of the IgG1 isotype having a mutation in the Fc region that enhances clustering of IgG molecules after cell-surface antigen binding.
    Type: Application
    Filed: June 7, 2018
    Publication date: August 6, 2020
    Inventors: Mette Hamborg JENSEN, Lene Schantz HARLOW, Andrew HAGARMAN, Cale HALBLEIB
  • FORMULATION FOR ANTIBODY AND DRUG CONJUGATE THEREOF
    Publication number: 20190030180
    Abstract: Disclosed herein are surfactant free antibody and antibody-drug-conjugate (ADC) formulations for anti-AXL antibodies and ADCs, including aqueous formulations, lyophilized formulations, and reconstituted formulations, as well as related processes and uses. The formulations are particularly suitable for an anti-AXL ADC based on an auristatin or DM1 derivative or other similarly hydrophobic drugs. Some formulations comprise histidine and mannitol.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 31, 2019
    Inventors: Lene Schantz HARLOW, Timothy Warren PAUL, Brendan M. MAYHUGH, Kelly Ann ROBY, Gregory Allan SACHA, Xiaona JING, Andrew HAGARMAN, Cale HALBLEIB
  • PROCESSES FOR RECEPTOR SCREENING
    Publication number: 20070269903
    Abstract: A method is provided for measuring competitive binding activity of molecules to nuclear receptors comprising mixing a fluorescence-emitting compound that specifically binds to steroid hormone receptors in a solution wherein the fluorescence-emitting compound is in concentration below the dissociation constant and the steroid hormone receptors are at or above the dissociation constant using fluorescence polarization.
    Type: Application
    Filed: May 23, 2007
    Publication date: November 22, 2007
    Applicant: Invitrogen Corporation
    Inventors: Cale Halbleib, Kerry Ervin, Mohammed Shekhani, Robert Lowery, William Checovich, Thomas Burke