Patents by Inventor Caleb J. Bashor

Caleb J. Bashor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for control of gene expression
    Patent number: 11781149
    Abstract: Embodiments disclosed herein provide artificial expression systems comprising multivalent transcription factor complexes for cooperative transcription factor assembly and modulating gene expression. More specifically, engineered synthetic transcription factors are recruited and structurally organized on synthetic gene circuits using molecular clamps, where the strength of intra-complex interactions can be modulated for fine tuning of gene expression as desired.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: October 10, 2023
    Assignee: Trustees of Boston University
    Inventors: Ahmad S. Khalil, Caleb J. Bashor, Nikit Patel, James J. Collins
  • SYSTEMS AND METHODS FOR CONTROL OF GENE EXPRESSION
    Publication number: 20230313215
    Abstract: Embodiments disclosed herein provide artificial expression systems comprising multivalent transcription factor complexes for cooperative transcription factor assembly and modulating gene expression. More specifically, engineered synthetic transcription factors are recruited and structurally organized on synthetic gene circuits using molecular clamps, where the strength of intra-complex interactions can be modulated for fine tuning of gene expression as desired.
    Type: Application
    Filed: May 31, 2023
    Publication date: October 5, 2023
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Ahmad S. Khalil, Caleb J. Bashor, Nikit Patel, James J. Collins
  • METHODS FOR EXPERIMENTAL EVOLUTION OF NATURAL AND SYNTHETIC MICROBES
    Publication number: 20210214713
    Abstract: Disclosed herein are a high-throughput continuous culture system and novel methodologies for the experimental evolution of natural and synthetic microbes using the continuous culture system. The microbial culture is exposed to a stress ramp function which is overlaid on top of a culture fitness function. The amount of stress applied to the culture is increased in response to increased fitness of the microbial culture.
    Type: Application
    Filed: February 17, 2018
    Publication date: July 15, 2021
    Applicants: Massachusetts Institute of Technology, Trustees of Boston University
    Inventors: Caleb J. Bashor, Jason Hung-Ying Yang, Arnaud Gutierrez, Wooseok Steven Ahn, James J. Collins, Brandon Gei-Chin Wong, Ahmad S. Khalil
  • METHODS FOR EXPERIMENTAL EVOLUTION OF NATURAL AND SYNTHETIC MICROBES
    Publication number: 20200199568
    Abstract: Disclosed herein are a high-throughput continuous culture system and novel methodologies for the experimental evolution of natural and synthetic microbes using the continuous culture system. The microbial culture is exposed to a stress ramp function which is overlaid on top of a culture fitness function. The amount of stress applied to the culture is increased in response to increased fitness of the microbial culture.
    Type: Application
    Filed: February 17, 2018
    Publication date: June 25, 2020
    Applicants: Massachusetts Institute of Technology, Trustees of Boston University
    Inventors: Caleb J. Bashor, Jason Hung-Ying Yang, Arnaud Gutierrez, Wooseok Steven Ahn, James J. Collins, Brandon Gei-Chin Wong, Ahmad S. Khalil
  • SYSTEMS AND METHODS FOR CONTROL OF GENE EXPRESSION
    Publication number: 20200002710
    Abstract: Embodiments disclosed herein provide artificial expression systems comprising multivalent transcription factor complexes for cooperative transcription factor assembly and modulating gene expression. More specifically, engineered synthetic transcription factors are recruited and structurally organized on synthetic gene circuits using molecular clamps, where the strength of intra-complex interactions can be modulated for fine tuning of gene expression as desired.
    Type: Application
    Filed: June 28, 2019
    Publication date: January 2, 2020
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Ahmad S. Khalil, Caleb J. Bashor, Nikit Patel, James J. Collins
  • Method to engineer MAPK signaling responses using synthetic scaffold interactions and scaffold-mediated feedback loops
    Patent number: 7879590
    Abstract: Synthetic scaffold interactions and scaffold-mediated feedback loops are used to engineer MAPK signaling responses in cells.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: February 1, 2011
    Assignee: Regents of the University of California
    Inventors: Wendell A. Lim, Caleb J. Bashor
  • Method to Engineer MAPK Signaling Responses Using Synthetic Scaffold Interactions and Scaffold-Mediated Feedback Loops
    Publication number: 20090233364
    Abstract: Synthetic scaffold interactions and scaffold-mediated feedback loops are used to engineer MAPK signaling responses in cells.
    Type: Application
    Filed: March 13, 2008
    Publication date: September 17, 2009
    Inventors: Wendell A. Lim, Caleb J. Bashor