Abstract: In some embodiments, the subject matter of this disclosure relates to systems and methods for designing and conducting clinical trials and biomarker validation studies. An example method includes: obtaining access to a trained computer-implemented model; providing, to the trained computer-implemented model, a plurality of sets of values for a plurality of features, each set of values corresponding to a candidate individual from a set of candidate individuals; receiving, from the trained computer-implemented model, a prediction of a disease state for each set of values; identifying, from the predictions of the disease state, a group of participants from the set of candidate individuals; and facilitating at least one of a clinical trial or a biomarker validation study involving the group of participants.

Abstract: Capability of a user equipment to support machine learning adaptation by a base station of a reference signal pattern is signaled between the base station and the user equipment. Configuration information from the base station indicates one or more of enabling or disabling of machine learning adaptation of the reference signal pattern, a machine learning model used for machine learning adaptation of the reference signal pattern, updated model parameters for the machine learning model, or whether model parameters received from the user equipment will be used for machine learning adaptation of the reference signal pattern. Model training may be performed or model parameters received, and reference signals are received from the base station. Information on a reference signal pattern may be transmitted by the user equipment to the serving base station. Assistance information may be transmitted by the user equipment to the base station, which configures a reference signal pattern.

Abstract: A connection box with novel integrated multi-port connectors provides a convenient and low cost method to fast connect/disconnect multiple external devices to/from the laptop or mobile devices simultaneously. It also allows fast switching connection of the external devices among connected desktop, laptops and mobile devices.