Abstract: Methods and compositions for actively loading of therapeutic compositions into yeast-generated extracellular vesicles (EVs) and their methods of use in treating one or more diseases or conditions.

Abstract: The present invention provides methods for detecting the presence of at least one revertant virus in a sample containing an attenuated virus by single-molecule real-time (SMRT) sequencing. It further provides methods for the quantitative analysis of a mixture of virus haplotypes in a virus sample by SMRT sequencing. It also provides kits useful in performing said methods.

Abstract: Systems and methods are disclosed for compressing and comparing data such as genomic data. The disclosed systems and methods may include selecting a segment, creating a delta representation of the segment, the delta representation comprising a script, and storing the script. Furthermore, the disclosed systems and methods may include receiving a first script comprising a compressed version of a first segment and receiving a second script comprising a compressed version of a second segment. The disclosed systems and methods may further include comparing the first script to the second script and determining if the first segment matches the second segment based upon the comparison of the first script to the second script.