Patents by Inventor Calogera M. Simonaro

Calogera M. Simonaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR ACTIVATING SIGNALING THROUGH THE CB2 CANNABINOID RECEPTOR FOR TREATING AND PREVENTING LYSOSOMAL STORAGE DISEASES AND DISORDERS
    Publication number: 20230181540
    Abstract: The present invention provides, inter alia, compositions, methods, and diagnostics for using CB2 cannabinoid receptor agonists for treating and preventing lysosomal storage disorders.
    Type: Application
    Filed: May 20, 2021
    Publication date: June 15, 2023
    Inventors: Edward H. SCHUCHMAN, Calogera M. SIMONARO
  • CERAMIDASE AND CELL DIFFERENTIATION
    Publication number: 20190321454
    Abstract: The present invention relates to methods of producing chondrocytes, improving the phenotype of a chondrocyte population, promoting chondrogenesis, maintaining a cell population in a differentiated state or increasing the number of cells of a population in a differentiated state, producing a population of differentiated cells, and treating certain diseases or disorders.
    Type: Application
    Filed: June 5, 2019
    Publication date: October 24, 2019
    Inventors: Edward H. Schuchman, Calogera M. Simonaro
  • Ceramidase and cell differentiation
    Patent number: 10350277
    Abstract: The present invention relates to methods of producing chondrocytes, improving the phenotype of a chondrocyte population, promoting chondrogenesis, maintaining a cell population in a differentiated state or increasing the number of cells of a population in a differentiated state, producing a population of differentiated cells, and treating certain diseases or disorders. Each of these methods involves treating a cell population with, and/or culturing a cell population in, a ceramidase.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: July 16, 2019
    Assignee: Icahn School of Medicine at Mount Sinai
    Inventors: Edward H. Schuchman, Calogera M. Simonaro
  • Anti-TNF-? therapy for the mucopolysaccharidoses and other lysosomal disorders
    Patent number: 9155784
    Abstract: The present invention relates to methods of treating a subject with a lysosomal disorder, by administering an agent for enzyme replacement therapy and an agent for anti-TNF-? therapy; by administering a pentosan polysulfate therapy; or by administering a substrate reduction therapy and an anti-TNF-? therapy. The invention further relates to a method of reducing inflammatory cytokines in a subject with a lysosomal disorder that is being treated by enzyme replacement therapy, by administering an agent for anti-TNF-? therapy.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: October 13, 2015
    Assignee: Icahn School of Medicine at Mount Sinai
    Inventors: Edward H. Schuchman, Calogera M. Simonaro, Gary E. Striker, Helen Vlassara
  • CERAMIDASE AND CELL DIFFERENTIATION
    Publication number: 20140287015
    Abstract: The present invention relates to methods of producing chondrocytes, improving the phenotype of a chondrocyte population, promoting chondrogenesis, maintaining a cell population in a differentiated state or increasing the number of cells of a population in a differentiated state, producing a population of differentiated cells, and treating certain diseases or disorders.
    Type: Application
    Filed: September 7, 2012
    Publication date: September 25, 2014
    Applicant: MOUNT SINAI SCHOOL OF MEDICINE
    Inventors: Edward H. Schuchman, Calogera M. Simonaro
  • ANTI-TNF-ALPHA THERAPY FOR THE MUCOPOLYSACCHARIDOSES AND OTHER LYSOSOMAL DISORDERS
    Publication number: 20140205584
    Abstract: The present invention relates to methods of treating a subject with a lysosomal disorder, by administering an agent for enzyme replacement therapy and an agent for anti-TNF-? therapy; by administering a pentosan polysulfate therapy; or by administering a substrate reduction therapy and an anti-TNF-? therapy. The invention further relates to a method of reducing inflammatory cytokines in a subject with a lysosomal disorder that is being treated by enzyme replacement therapy, by administering an agent for anti-TNF-? therapy.
    Type: Application
    Filed: June 20, 2012
    Publication date: July 24, 2014
    Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Edward H. Schuchman, Calogera M. Simonaro, Gary E. Striker, Helen Vlassara