Patents by Inventor Calum E. MacAulay

Calum E. MacAulay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190269333
    Abstract: A system provides combined diffuse optical microscopy (DOM) and fluorescence endomicroscopy (FE). The system may use a single light source which generates structured illumination for both modalities. FE and DOM images may be displayed for qualitative assessment. Quantitative assessments may be based on both FE and DOM images. The quantitative assessments may be applied to characterize tissues. Some embodiments provide multi-spectral DOM.
    Type: Application
    Filed: November 21, 2017
    Publication date: September 5, 2019
    Inventors: Nico BODENSCHATZ, Calum E. MACAULAY
  • Patent number: 8668640
    Abstract: Endoscopes and other viewing devices that control the light that contacts a sample and/or that is detected emanating from a sample. The viewing devices are particularly well suited for in vivo imaging, although other uses are also included. The viewing devices, and methods related thereto, comprise a spatial light modulator in the illumination and/or detection light path so that light transmitted to the target via a bundle of light guides or optical system is transmitted substantially only into the cores of the light guide bundle and not into the cladding surrounding the light guides, filler between the light guides in the bundle, or undesired light guides. Also, methods and apparatus for mapping the pixels of the spatial light modulator to the cores of the light guides in the bundle (preferably at least 3 pixels (e.g., at least 3 mirrors for a digital micromirror device) for each core), as well as for mapping the light guides of one light guide bundle to another.
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: March 11, 2014
    Assignee: Motic China Group Co., Ltd.
    Inventors: Calum E. MacAulay, Andrew L. P. Dlugan, Pierre Lane
  • Patent number: 8570635
    Abstract: Lighting systems comprising a spectrum former upstream from a reflective pixelated spatial light modulator (reflective SLM), the SLM reflecting substantially all of the light in the spectrum into at least two different light paths, that do not reflect back to the light source or the spectrum former. At least one of the light paths acts as a projection light path and transmits desired light out of the lighting system. The lighting systems provide virtually any desired color(s) and intensity(s) of light, and avoid overheating problems by deflecting unwanted light and other electromagnetic radiation out of the system or to a heat management system. The systems can be part of another system, a luminaire, or any other suitable light source. The systems can provide virtually any desired light, from the light seen at the break of morning to specialized light for treating cancer or psoriasis, and may change color and intensity at speeds that are perceptually instantaneous.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: October 29, 2013
    Assignee: Tidal Photonics, Inc.
    Inventors: Nicholas B. MacKinnon, Calum E. MacAulay, Ulrich Stange
  • Patent number: 8249326
    Abstract: Methods and apparatus for assessing tissue pathology involve computing an index having a value based upon measures of a plurality of morphological features of cell nuclei in the tissue. The methods may be performed completely automatically or semi-automatically. The index value can be predictive of outcome. The index value may be determined by computing discriminant scores for the cell nuclei based upon values of the measures of morphological features and classifying the nuclei into bins based upon the discriminant score values. The index may be based upon proportions of the nuclei classified in different ones of the bins.
    Type: Grant
    Filed: November 27, 2006
    Date of Patent: August 21, 2012
    Assignee: British Columbia Cancer Agency Branch
    Inventors: Calum E. Macaulay, Martial Daniel Guillaud, Miriam Pearl Rosin
  • Publication number: 20110051216
    Abstract: Lighting systems comprising a spectrum former upstream from a reflective pixelated spatial light modulator (reflective SLM), the SLM reflecting substantially all of the light in the spectrum into at least two different light paths, that do not reflect back to the light source or the spectrum former. At least one of the light paths acts as a projection light path and transmits desired light out of the lighting system. The lighting systems provide virtually any desired color(s) and intensity(s) of light, and avoid overheating problems by deflecting unwanted light and other electromagnetic radiation out of the system or to a heat management system. The systems can be part of another system, a luminaire, or any other suitable light source. The systems can provide virtually any desired light, from the light seen at the break of morning to specialized light for treating cancer or psoriasis, and may change color and intensity at speeds that are perceptually instantaneous.
    Type: Application
    Filed: August 27, 2010
    Publication date: March 3, 2011
    Applicant: TIDAL PHOTONICS, INC.
    Inventors: NICHOLAS B. MACKINNON, CALUM E. MACAULAY, ULRICH STANGE
  • Patent number: 7796319
    Abstract: Lighting systems comprising a spectrum former upstream from a reflective pixelated spatial light modulator (reflective SLM), the SLM reflecting substantially all of the light in the spectrum into at least two different light paths, that do not reflect back to the light source or the spectrum former. At least one of the light paths acts as a projection light path and transmits desired light out of the lighting system. The lighting systems provide virtually any desired color(s) and intensity(s) of light, and avoid overheating problems by deflecting unwanted light and other electromagnetic radiation out of the system or to a heat management system. The systems can be part of another system, a luminaire, or any other suitable light source. The systems can provide virtually any desired light, from the light seen at the break of morning to specialized light for treating cancer or psoriasis, and may change color and intensity at speeds that are perceptually instantaneous.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: September 14, 2010
    Assignee: Tidal Photonics, Inc.
    Inventors: Nicholas B. MacKinnon, Ulrich Stange, Calum E. MacAulay
  • Patent number: 7755832
    Abstract: Apparatus and methods relating to microscopes having specific control of the light that contacts a sample and/or a light detector, such as the eye of the user, a charge couple device or a video camera. The improved control includes enhanced, selective control of the angle of illumination, quantity of light and location of light reaching the sample and/or detector. The microscopes comprise one or more spatial light modulators in the illumination and/or detection light path of the microscope at one or both of the conjugate image plane of the aperture diaphragm of the objective lens and the conjugate image plane of the sample.
    Type: Grant
    Filed: August 19, 2008
    Date of Patent: July 13, 2010
    Assignee: Motic China Group Co., Ltd.
    Inventor: Calum E. MacAulay
  • Publication number: 20090244272
    Abstract: Endoscopes and other viewing devices that control the light that contacts a sample and/or that is detected emanating from a sample. The viewing devices are particularly well suited for in vivo imaging, although other uses are also included. The viewing devices, and methods related thereto, comprise a spatial light modulator in the illumination and/or detection light path so that light transmitted to the target via a bundle of light guides or optical system is transmitted substantially only into the cores of the light guide bundle and not into the cladding surrounding the light guides, filler between the light guides in the bundle, or undesired light guides. Also, methods and apparatus for mapping the pixels of the spatial light modulator to the cores of the light guides in the bundle (preferably at least 3 pixels (e.g., at least 3 mirrors for a digital micromirror device) for each core), as well as for mapping the light guides of one light guide bundle to another.
    Type: Application
    Filed: October 27, 2008
    Publication date: October 1, 2009
    Applicant: Motic China Group Co., Ltd.
    Inventors: Calum E. MacAulay, Andrew L.P. Dlugan, Pierre M. Lane
  • Publication number: 20090225391
    Abstract: Lighting systems comprising a spectrum former upstream from a reflective pixelated spatial light modulator (reflective SLM), the SLM reflecting substantially all of the light in the spectrum into at least two different light paths, that do not reflect back to the light source or the spectrum former. At least one of the light paths acts as a projection light path and transmits desired light out of the lighting system. The lighting systems provide virtually any desired color(s) and intensity(s) of light, and avoid overheating problems by deflecting unwanted light and other electromagnetic radiation out of the system or to a heat management system. The systems can be part of another system, a luminaire, or any other suitable light source. The systems can provide virtually any desired light, from the light seen at the break of morning to specialized light for treating cancer or psoriasis, and may change color and intensity at speeds that are perceptually instantaneous.
    Type: Application
    Filed: September 30, 2008
    Publication date: September 10, 2009
    Applicant: Tidal Photonics, Inc.
    Inventors: Nicholas B. MacKinnon, Calum E. MacAulay, Ulrich Stange
  • Publication number: 20080316571
    Abstract: Apparatus and methods relating to microscopes having specific control of the light that contacts a sample and/or a light detector, such as the eye of the user, a charge couple device or a video camera. The improved control includes enhanced, selective control of the angle of illumination, quantity of light and location of light reaching the sample and/or detector. The microscopes comprise one or more spatial light modulators in the illumination and/or detection light path of the microscope at one or both of the conjugate image plane of the aperture diaphragm of the objective lens and the conjugate image plane of the sample.
    Type: Application
    Filed: August 19, 2008
    Publication date: December 25, 2008
    Applicant: Motic China Group Co., Ltd.
    Inventor: Calum E. MacAulay
  • Publication number: 20080304733
    Abstract: Methods and apparatus for assessing tissue pathology involve computing an index having a value based upon measures of a plurality of morphological features of cell nuclei in the tissue. The methods may be performed completely automatically or semi-automatically. The index value can be predictive of outcome. The index value may be determined by computing discriminant scores for the cell nuclei based upon values of the measures of morphological features and classifying the nuclei into bins based upon the discriminant score values. The index may be based upon proportions of the nuclei classified in different ones of the bins.
    Type: Application
    Filed: November 27, 2006
    Publication date: December 11, 2008
    Inventors: Calum E. Macaulay, Martial Daniel Guillaud, Miriam Pearl Rosin
  • Patent number: 7274809
    Abstract: Computer programs, systems and the like related to processing, segmenting and feature normalizing digital images. The images are of cells and the methods are useful for the detection of malignancy-associated changes (MAC) in cells, which can be used for the detection of cancer. The programs and methods detect cancer in one tissue by detecting MAC in another tissue, such as associated tissues or non-associated tissues. Examples of associated tissues include nipple aspirates or ductal washings to detect breast cancer, and sputum or bronchial lavage to detect lung cancer. Examples of non-associated tissues include buccal mucosa to detect lung or breast cancer.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: September 25, 2007
    Assignee: Perceptronix Medical, Inc. and British Columbia Cancer Agency
    Inventors: Calum E. MacAulay, Alexei K. Doudkine, David M. Garner, Margareta Flezar, Mario Zganec, Jaka Lavrencak, Branko M. Palcic, Gary W. Ferguson
  • Patent number: 7235047
    Abstract: Endoscopes and other viewing devices that control the light that contacts a sample and/or that is detected emanating from a sample. The viewing devices are particularly well suited for in vivo imaging, although other uses are also included. The viewing devices, and methods related thereto, comprise a spatial light modulator in the illumination and/or detection light path so that light transmitted to the target via a bundle of light guides or optical system is transmitted substantially only into the cores of the light guide bundle and not into the cladding surrounding the light guides, filler between the light guides in the bundle, or undesired light guides. Also, methods and apparatus for mapping the pixels of the spatial light modulator to the cores of the light guides in the bundle (preferably at least 3 pixels (e.g., at least 3 mirrors for a digital micromirror device) for each core), as well as for mapping the light guides of one light guide bundle to another.
    Type: Grant
    Filed: October 17, 2003
    Date of Patent: June 26, 2007
    Assignee: Motic China Group, Ltd.
    Inventors: Calum E. MacAulay, Andrew L. P. Dlugan, Pierre M. Lane
  • Patent number: 7151601
    Abstract: Lighting systems comprising a spectrum former upstream from a reflective pixelated spatial light modulator (reflective SLM), the SLM reflecting substantially all of the light in the spectrum into at least two different light paths, that do not reflect back to the light source or the spectrum former. At least one of the light paths acts as a projection light path and transmits desired light out of the lighting system. The lighting systems provide virtually any desired color(s) and intensity(s) of light, and avoid overheating problems by deflecting unwanted light and other electromagnetic radiation out of the system or to a heat management system. The systems can be part of another system, a luminaire, or any other suitable light source. The systems can provide virtually any desired light, from the light seen at the break of morning to specialized light for treating cancer or psoriasis, and may change color and intensity at speeds that are perceptually instantaneous.
    Type: Grant
    Filed: May 25, 2004
    Date of Patent: December 19, 2006
    Assignee: Tidal Photonics, Inc.
    Inventors: Nicholas B. MacKinnon, Calum E. MacAulay, Ulrich Stange
  • Publication number: 20040262534
    Abstract: Microarray readers and methods that compensate for target spots that are too dim or too bright for the microarray reader to accurately measure. The readers adjust the amount of light directed at or received from specific non-acceptable target spots, such that dim spots receive more excitation light and overly bright spots receive less. This increases or decreases, respectively, their measured brightness, which in turn effectively increases the range over which a microarray reader can accurately measure the spots, and can also improve the signal-to-noise ratio and other aspects of the measurements.
    Type: Application
    Filed: March 24, 2004
    Publication date: December 30, 2004
    Inventors: Calum E. MacAulay, Pierre M. Lane
  • Publication number: 20040218177
    Abstract: Lighting systems comprising a spectrum former upstream from a reflective pixelated spatial light modulator (reflective SLM), the SLM reflecting substantially all of the light in the spectrum into at least two different light paths, that do not reflect back to the light source or the spectrum former. At least one of the light paths acts as a projection light path and transmits desired light out of the lighting system. The lighting systems provide virtually any desired color(s) and intensity(s) of light, and avoid overheating problems by deflecting unwanted light and other electromagnetic radiation out of the system or to a heat management system. The systems can be part of another system, a luminaire, or any other suitable light source. The systems can provide virtually any desired light, from the light seen at the break of morning to specialized light for treating cancer or psoriasis, and may change color and intensity at speeds that are perceptually instantaneous.
    Type: Application
    Filed: May 25, 2004
    Publication date: November 4, 2004
    Inventors: Nicholas B. MacKinnon, Calum E. MacAulay, Ulrich Stange
  • Patent number: 6794658
    Abstract: Microarray readers and methods that compensate for target spots that are too dim or too bright for the microarray reader to accurately measure. The readers adjust the amount of light directed at or received from specific non-acceptable target spots, such that dim spots receive more excitation light and overly bright spots receive less. This increases or decreases, respectively, their measured brightness, which in turn effectively increases the range over which a microarray reader can accurately measure the spots, and can also improve the signal-to-noise ratio and other aspects of the measurements.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: September 21, 2004
    Assignee: Digital Optical Imaging Corporation
    Inventors: Calum E. MacAulay, Pierre M. Lane
  • Patent number: 6781691
    Abstract: Lighting systems comprising a spectrum former upstream from a reflective pixelated spatial light modulator (reflective SLM), the SLM reflecting substantially all of the light in the spectrum into at least two different light paths, that do not reflect back to the light source or the spectrum former. At least one of the light paths acts as a projection light path and transmits desired light out of the lighting system. The lighting systems provide virtually any desired color(s) and intensity(s) of light, and avoid overheating problems by deflecting unwanted light and other electromagnetic radiation out of the system or to a heat management system. The systems can be part of another system, a luminaire, or any other suitable light source. The systems can provide virtually any desired light, from the light seen at the break of morning to specialized light for treating cancer or psoriasis, and may change color and intensity at speeds that are perceptually instantaneous.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: August 24, 2004
    Assignee: Tidal Photonics, Inc.
    Inventors: Nicholas B. MacKinnon, Calum E. MacAulay, Ulrich Stange
  • Publication number: 20040147808
    Abstract: Endoscopes and other viewing devices that control the light that contacts a sample and/or that is detected emanating from a sample. The viewing devices are particularly well suited for in vivo imaging, although other uses are also included. The viewing devices, and methods related thereto, comprise a spatial light modulator in the illumination and/or detection light path so that light transmitted to the target via a bundle of light guides or optical system is transmitted substantially only into the cores of the light guide bundle and not into the cladding surrounding the light guides, filler between the light guides in the bundle, or undesired light guides. Also, methods and apparatus for mapping the pixels of the spatial light modulator to the cores of the light guides in the bundle (preferably at least 3 pixels (e.g., at least 3 mirrors for a digital micromirror device) for each core), as well as for mapping the light guides of one light guide bundle to another.
    Type: Application
    Filed: October 17, 2003
    Publication date: July 29, 2004
    Inventors: Calum E. MacAulay, Andrew L.P. Dlugan, Pierre M. Lane
  • Publication number: 20040047030
    Abstract: Apparatus and methods relating to microscopes having specific control of the light that contacts a sample and/or a light detector, such as the eye of the user, a charge couple device or a video camera. The improved control includes enhanced, selective control of the angle of illumination, quantity of light and location of light reaching the sample and/or detector. The microscopes comprise one or more spatial light modulators in the illumination and/or detection light path of the microscope at one or both of the conjugate image plane of the aperture diaphragm of the objective lens and the conjugate image plane of the sample.
    Type: Application
    Filed: October 25, 2001
    Publication date: March 11, 2004
    Applicant: Digital Optical Imaging Corporation
    Inventor: Calum E. MacAulay