Patents by Inventor Calvin Bruce
Calvin Bruce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180280413Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.Type: ApplicationFiled: October 13, 2017Publication date: October 4, 2018Applicant: Telomerase Activation Sciences, Inc.Inventors: Calvin Bruce HARLEY, Soo-Peang KHOR, Mahesh RAMASESHAN, Premchandran H. RAMIYA, Zhu Z. PIROT, Steven FAUCE, Tong LIN
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Patent number: 9913851Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.Type: GrantFiled: December 10, 2015Date of Patent: March 13, 2018Assignee: TELOMERASE ACTIVATION SCIENCES, INC.Inventors: Calvin Bruce Harley, Soo-Peang Khor, Mahesh Ramaseshan, Premchandran H. Ramiya, Zhu Z. Pirot, Steven Fauce, Tong Lin
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Publication number: 20160318973Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.Type: ApplicationFiled: December 10, 2015Publication date: November 3, 2016Inventors: Calvin Bruce HARLEY, Soo-Peang KHOR, Mahesh RAMASESHAN, Premchandran H. RAMIYA, Zhu Z. PIROT, Steven FAUCE, Tong LIN
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Patent number: 9403866Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.Type: GrantFiled: July 8, 2013Date of Patent: August 2, 2016Assignee: TELOMERASE ACTIVATION SCIENCES, INC.Inventors: Calvin Bruce Harley, Soo-Peang Khor, Mahesh Ramaseshan, Premchandran H. Ramiya, Zhu Z. Pirot, Steven Fauce, Tong Lin
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Publication number: 20150093455Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.Type: ApplicationFiled: June 24, 2014Publication date: April 2, 2015Inventors: Calvin Bruce HARLEY, Allison C. CHIN, Tsutomu AKAMA, Nancy Yuk-Yu IP, Yung-Hou WONG, David M. MILLER-MARTINI
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Patent number: 8759304Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.Type: GrantFiled: March 5, 2010Date of Patent: June 24, 2014Assignee: Telomerase Activation Science, Inc.Inventors: Calvin Bruce Harley, Allison C. Chin, Tsutomu Akama, Nancy Yuk-yu Ip, Yung-hou Wong, David M. Miller-Martini
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Publication number: 20140088055Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.Type: ApplicationFiled: July 8, 2013Publication date: March 27, 2014Applicant: TELOMERASE ACTIVATION SCIENCES, INC.Inventors: Calvin Bruce HARLEY, Soo-Peang KHOR, Mahesh RAMASESHAN, Premchandran H. RAMIYA, Zhu Z. PIROT, Steven FAUCE, Tong LIN
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Publication number: 20110071095Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.Type: ApplicationFiled: March 5, 2010Publication date: March 24, 2011Applicant: Geron CorporationInventors: Calvin Bruce Harley, Allison C. Chin, Tsutomu Akama, Nancy Yuk-yu Ip, Yung-hou Wong, David M. Miller-Martini
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Patent number: 7846904Abstract: The present invention relates to methods for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The method and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin aliments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.Type: GrantFiled: June 23, 2004Date of Patent: December 7, 2010Assignee: Geron CorporationInventors: Calvin Bruce Harley, Allison C. Chin, Tsutomu Akama, Nancy Yuk-yu Ip, Yung-hou Wong, David M. Miller-Martini
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Publication number: 20080297768Abstract: A polarization mode dispersion analyzer having a light source, a sensor, an output phase signal analyzer, and a controller. The light source generates a probe light signal that is intensity modulated and also polarization modulated, the light source being adapted to apply the light signal to a device under test. The sensor generates an output phase signal related to the phase of the intensity modulation of an output optical signal leaving the device under test. The output phase signal analyzer measures an amplitude and phase of at least one frequency component of the output phase signal at a frequency related to the polarization modulation. The controller generates a signal indicative of a differential group delay of the device under test utilizing the measured amplitude and phase. The controller also measures a group delay associated with the device under test.Type: ApplicationFiled: June 1, 2007Publication date: December 4, 2008Inventors: Bogdan Szafraniec, Calvin Bruce Ward
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Publication number: 20080113925Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin aliments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.Type: ApplicationFiled: June 23, 2004Publication date: May 15, 2008Inventors: Calvin Bruce Harley, Allison C. Chin, Tsutomu Akama, Nancy Yuk-yu Ip, Wong Yung-hou, David M. Miller-Martini
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Patent number: 6373505Abstract: A method and apparatus for displaying information on a display device of limited display area. More specifically, an array of elements is formed on the display where each of the elements represents an attribute and has graphical information indicating the state of the attribute. Further, the position of each element in the array represents its position in a collection of attributes. Each element is also user selectable, so that when the element is selected, further information on the attribute is displayed.Type: GrantFiled: July 19, 1999Date of Patent: April 16, 2002Assignee: International Business Machines CorporationInventors: Rachel Katherine Emma Bellamy, Vicki Lynne Hanson, Wendy A. Kellogg, John Thomas Richards, Calvin Bruce Swart
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Patent number: 6051167Abstract: A carbon composite structure, for example, an automotive engine piston, is made by preparing a matrix including of a mixture of non crystalline carbon particulate soluble in an organic solvent and a binder that has a liquid phase. The non crystalline particulate also contains residual carbon hydrogen bonding. An uncured structure is formed by combining the matrix mixture, for example, carbon fibers such as graphite dispersed in the mixture and/or graphite cloth imbedded in the mixture. The uncured structure is cured by pyrolyzing it in an inert atmosphere such as argon. Advantageously, the graphite reinforcement material is whiskered prior to combining it with the matrix mixture by a novel method involving passing a gaseous metal suboxide over the graphite surface.Type: GrantFiled: January 15, 1998Date of Patent: April 18, 2000Assignee: Materials and Electrochemical Research (MER) CorporationInventors: James C. Withers, Raouf O. Loutfy, Witold Kowbel, Calvin Bruce, Ranji Vaidyanathan
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Patent number: 5973666Abstract: A television style channel (program) changer switch is electrically coupled to the central processing unit of a computer system. A user defined lookup table assigns switch positions to programs available for execution in the system. Program controlled means initiates execution of each program and switches between programs in accordance with the positioning of the switch by a system user.Type: GrantFiled: July 20, 1995Date of Patent: October 26, 1999Assignee: International Business Machines CorporationInventors: David Carroll Challener, Calvin Bruce Swart, Stephen Earle Fischer, William Brian Cunningham
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Patent number: 5891639Abstract: Telomerase activity in a sample can be measured using a two reaction protocol. The first reaction involves the formation of telomerase substrate extension products from a telomerase substrate. The second reaction involves replication of the telomerase substrate extension products and/or amplification of signal generated by a bound probe. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose a disease or other conditions of medical interest, as well as the course of disease progression or remission in a patient.Type: GrantFiled: June 18, 1998Date of Patent: April 6, 1999Assignee: Geron CorporationInventors: Calvin Bruce Harley, Nam Woo Kim, Scott Lawrence Weinrich
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Patent number: 5863726Abstract: Telomerase activity in a sample can be measured using a two reaction protocol. The first reaction involves the formation of telomerase substrate extension products from a telomerase substrate. The second reaction involves replication of the telomerase substrate extension products and/or amplification of signal generated by a bound probe. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose a disease or other conditions of medical interest, as well as the course of disease progression or remission in a patient.Type: GrantFiled: April 12, 1996Date of Patent: January 26, 1999Assignee: Geron CorporationInventors: Calvin Bruce Harley, Nam Woo Kim, Scott Lawrence Weinrich
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Patent number: 5840490Abstract: Methods for detecting hematologic and colorectal malignancies are provided comprising: (a) collecting a sample suspected of containing cancer cells; (b) analyzing the sample for telomerase activity; (c) correlating the presence of telomerase activity with the presence of cancer cells. A method for staging leukemia is also provided comprising analyzing a blood or bone marrow sample for telomerase activity, correlating the activity with a standard level of telomerase activity, and correlating a low telomerase activity with early stage leukemia.Type: GrantFiled: June 7, 1995Date of Patent: November 24, 1998Assignee: McMaster UniversityInventors: Silvia Bacchetti, Christopher M. Counter, Brian Leber, Calvin Bruce Harley
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Patent number: 5837453Abstract: Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose the course of disease progression in a patient.Type: GrantFiled: June 7, 1995Date of Patent: November 17, 1998Assignee: Geron CorporationInventors: Calvin Bruce Harley, Nam Woo Kim, Scott Lawrence Weinrich
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Patent number: 5804380Abstract: Telomerase activity in a sample can be measured using a two reaction protocol. The first reaction involves the formation of telomerase substrate extension products from a telomerase substrate. The second reaction involves replication of the telomerase substrate extension products and/or amplification of signal generated by a bound probe. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose a disease or other conditions of medical interest, as well as the course of disease progression or remission in a patient.Type: GrantFiled: April 15, 1996Date of Patent: September 8, 1998Assignee: Geron CorporationInventors: Calvin Bruce Harley, Nam Woo Kim, Scott Lawrence Weinrich
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Patent number: 4333961Abstract: A monolayer magnetic coating is prepared by applying magnetic particles which have an electrostatic charge in an aqueous environment to an active layer on a substrate, the active layer having an electrostatic charge in an aqueous environment opposite to the charge on the magnetic particles so that the particles bond to the active layer.Type: GrantFiled: April 30, 1981Date of Patent: June 8, 1982Assignee: International Business Machines CorporationInventors: Calvin A. Bruce, Andrew M. Homola, Max R. Lorenz