Patents by Inventor Calvin Bruce

Calvin Bruce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180280413
    Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
    Type: Application
    Filed: October 13, 2017
    Publication date: October 4, 2018
    Applicant: Telomerase Activation Sciences, Inc.
    Inventors: Calvin Bruce HARLEY, Soo-Peang KHOR, Mahesh RAMASESHAN, Premchandran H. RAMIYA, Zhu Z. PIROT, Steven FAUCE, Tong LIN
  • Patent number: 9913851
    Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: March 13, 2018
    Assignee: TELOMERASE ACTIVATION SCIENCES, INC.
    Inventors: Calvin Bruce Harley, Soo-Peang Khor, Mahesh Ramaseshan, Premchandran H. Ramiya, Zhu Z. Pirot, Steven Fauce, Tong Lin
  • Publication number: 20160318973
    Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
    Type: Application
    Filed: December 10, 2015
    Publication date: November 3, 2016
    Inventors: Calvin Bruce HARLEY, Soo-Peang KHOR, Mahesh RAMASESHAN, Premchandran H. RAMIYA, Zhu Z. PIROT, Steven FAUCE, Tong LIN
  • Patent number: 9403866
    Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: August 2, 2016
    Assignee: TELOMERASE ACTIVATION SCIENCES, INC.
    Inventors: Calvin Bruce Harley, Soo-Peang Khor, Mahesh Ramaseshan, Premchandran H. Ramiya, Zhu Z. Pirot, Steven Fauce, Tong Lin
  • Publication number: 20150093455
    Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
    Type: Application
    Filed: June 24, 2014
    Publication date: April 2, 2015
    Inventors: Calvin Bruce HARLEY, Allison C. CHIN, Tsutomu AKAMA, Nancy Yuk-Yu IP, Yung-Hou WONG, David M. MILLER-MARTINI
  • Patent number: 8759304
    Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
    Type: Grant
    Filed: March 5, 2010
    Date of Patent: June 24, 2014
    Assignee: Telomerase Activation Science, Inc.
    Inventors: Calvin Bruce Harley, Allison C. Chin, Tsutomu Akama, Nancy Yuk-yu Ip, Yung-hou Wong, David M. Miller-Martini
  • Publication number: 20140088055
    Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
    Type: Application
    Filed: July 8, 2013
    Publication date: March 27, 2014
    Applicant: TELOMERASE ACTIVATION SCIENCES, INC.
    Inventors: Calvin Bruce HARLEY, Soo-Peang KHOR, Mahesh RAMASESHAN, Premchandran H. RAMIYA, Zhu Z. PIROT, Steven FAUCE, Tong LIN
  • Publication number: 20110071095
    Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
    Type: Application
    Filed: March 5, 2010
    Publication date: March 24, 2011
    Applicant: Geron Corporation
    Inventors: Calvin Bruce Harley, Allison C. Chin, Tsutomu Akama, Nancy Yuk-yu Ip, Yung-hou Wong, David M. Miller-Martini
  • Patent number: 7846904
    Abstract: The present invention relates to methods for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The method and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin aliments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
    Type: Grant
    Filed: June 23, 2004
    Date of Patent: December 7, 2010
    Assignee: Geron Corporation
    Inventors: Calvin Bruce Harley, Allison C. Chin, Tsutomu Akama, Nancy Yuk-yu Ip, Yung-hou Wong, David M. Miller-Martini
  • Publication number: 20080297768
    Abstract: A polarization mode dispersion analyzer having a light source, a sensor, an output phase signal analyzer, and a controller. The light source generates a probe light signal that is intensity modulated and also polarization modulated, the light source being adapted to apply the light signal to a device under test. The sensor generates an output phase signal related to the phase of the intensity modulation of an output optical signal leaving the device under test. The output phase signal analyzer measures an amplitude and phase of at least one frequency component of the output phase signal at a frequency related to the polarization modulation. The controller generates a signal indicative of a differential group delay of the device under test utilizing the measured amplitude and phase. The controller also measures a group delay associated with the device under test.
    Type: Application
    Filed: June 1, 2007
    Publication date: December 4, 2008
    Inventors: Bogdan Szafraniec, Calvin Bruce Ward
  • Publication number: 20080113925
    Abstract: The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin aliments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
    Type: Application
    Filed: June 23, 2004
    Publication date: May 15, 2008
    Inventors: Calvin Bruce Harley, Allison C. Chin, Tsutomu Akama, Nancy Yuk-yu Ip, Wong Yung-hou, David M. Miller-Martini
  • Patent number: 6373505
    Abstract: A method and apparatus for displaying information on a display device of limited display area. More specifically, an array of elements is formed on the display where each of the elements represents an attribute and has graphical information indicating the state of the attribute. Further, the position of each element in the array represents its position in a collection of attributes. Each element is also user selectable, so that when the element is selected, further information on the attribute is displayed.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: April 16, 2002
    Assignee: International Business Machines Corporation
    Inventors: Rachel Katherine Emma Bellamy, Vicki Lynne Hanson, Wendy A. Kellogg, John Thomas Richards, Calvin Bruce Swart
  • Patent number: 6051167
    Abstract: A carbon composite structure, for example, an automotive engine piston, is made by preparing a matrix including of a mixture of non crystalline carbon particulate soluble in an organic solvent and a binder that has a liquid phase. The non crystalline particulate also contains residual carbon hydrogen bonding. An uncured structure is formed by combining the matrix mixture, for example, carbon fibers such as graphite dispersed in the mixture and/or graphite cloth imbedded in the mixture. The uncured structure is cured by pyrolyzing it in an inert atmosphere such as argon. Advantageously, the graphite reinforcement material is whiskered prior to combining it with the matrix mixture by a novel method involving passing a gaseous metal suboxide over the graphite surface.
    Type: Grant
    Filed: January 15, 1998
    Date of Patent: April 18, 2000
    Assignee: Materials and Electrochemical Research (MER) Corporation
    Inventors: James C. Withers, Raouf O. Loutfy, Witold Kowbel, Calvin Bruce, Ranji Vaidyanathan
  • Patent number: 5973666
    Abstract: A television style channel (program) changer switch is electrically coupled to the central processing unit of a computer system. A user defined lookup table assigns switch positions to programs available for execution in the system. Program controlled means initiates execution of each program and switches between programs in accordance with the positioning of the switch by a system user.
    Type: Grant
    Filed: July 20, 1995
    Date of Patent: October 26, 1999
    Assignee: International Business Machines Corporation
    Inventors: David Carroll Challener, Calvin Bruce Swart, Stephen Earle Fischer, William Brian Cunningham
  • Patent number: 5891639
    Abstract: Telomerase activity in a sample can be measured using a two reaction protocol. The first reaction involves the formation of telomerase substrate extension products from a telomerase substrate. The second reaction involves replication of the telomerase substrate extension products and/or amplification of signal generated by a bound probe. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose a disease or other conditions of medical interest, as well as the course of disease progression or remission in a patient.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: April 6, 1999
    Assignee: Geron Corporation
    Inventors: Calvin Bruce Harley, Nam Woo Kim, Scott Lawrence Weinrich
  • Patent number: 5863726
    Abstract: Telomerase activity in a sample can be measured using a two reaction protocol. The first reaction involves the formation of telomerase substrate extension products from a telomerase substrate. The second reaction involves replication of the telomerase substrate extension products and/or amplification of signal generated by a bound probe. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose a disease or other conditions of medical interest, as well as the course of disease progression or remission in a patient.
    Type: Grant
    Filed: April 12, 1996
    Date of Patent: January 26, 1999
    Assignee: Geron Corporation
    Inventors: Calvin Bruce Harley, Nam Woo Kim, Scott Lawrence Weinrich
  • Patent number: 5840490
    Abstract: Methods for detecting hematologic and colorectal malignancies are provided comprising: (a) collecting a sample suspected of containing cancer cells; (b) analyzing the sample for telomerase activity; (c) correlating the presence of telomerase activity with the presence of cancer cells. A method for staging leukemia is also provided comprising analyzing a blood or bone marrow sample for telomerase activity, correlating the activity with a standard level of telomerase activity, and correlating a low telomerase activity with early stage leukemia.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 24, 1998
    Assignee: McMaster University
    Inventors: Silvia Bacchetti, Christopher M. Counter, Brian Leber, Calvin Bruce Harley
  • Patent number: 5837453
    Abstract: Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose the course of disease progression in a patient.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 17, 1998
    Assignee: Geron Corporation
    Inventors: Calvin Bruce Harley, Nam Woo Kim, Scott Lawrence Weinrich
  • Patent number: 5804380
    Abstract: Telomerase activity in a sample can be measured using a two reaction protocol. The first reaction involves the formation of telomerase substrate extension products from a telomerase substrate. The second reaction involves replication of the telomerase substrate extension products and/or amplification of signal generated by a bound probe. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose a disease or other conditions of medical interest, as well as the course of disease progression or remission in a patient.
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: September 8, 1998
    Assignee: Geron Corporation
    Inventors: Calvin Bruce Harley, Nam Woo Kim, Scott Lawrence Weinrich
  • Patent number: 4333961
    Abstract: A monolayer magnetic coating is prepared by applying magnetic particles which have an electrostatic charge in an aqueous environment to an active layer on a substrate, the active layer having an electrostatic charge in an aqueous environment opposite to the charge on the magnetic particles so that the particles bond to the active layer.
    Type: Grant
    Filed: April 30, 1981
    Date of Patent: June 8, 1982
    Assignee: International Business Machines Corporation
    Inventors: Calvin A. Bruce, Andrew M. Homola, Max R. Lorenz