Abstract: An instrumentation analysis system processes data streams received from servers executing instrumented software. The system determines a set of servers that satisfy a given criteria, for example, a set of servers with high resource utilization. The set of servers may be determined by the system based on triggers or specified by a user. The system analyzes properties of servers to determine a property that characterizes the set of servers. The property characterizing the servers is provided to users via a user interface or alerts for further analysis, for example, to analyze the cause of high resource utilization.

Abstract: A laser leveling tool comprising: gesture control means comprises at least one sensor adapted to sense gestures and/or movements of a user; and a controller in communication with the gesture control means for receiving signals from the sensor and generating control commands for the tool based on the received signals, the control commands comprising at least ON/OFF states of laser beam patterns that the tool can project.

Abstract: According to embodiments, a method for navigating clusters of a data structure includes gathering data from the data structure by instrumenting instances of application software executing on the data structure. The method also includes identifying clusters of the data structure based on the gathered data. The method also includes causing display of a cluster map of the data structure, the cluster map comprising a plurality of clusters, each cluster of the plurality of clusters comprising a plurality of nodes, each node of the plurality of nodes comprising a plurality of pods, each pod of the plurality of pods comprising a plurality of containers. The method also includes providing a status for each node, each pod, and each container of each cluster. The method also includes causing display of analysis of each cluster of the cluster map, the analysis comprising granular information for each cluster.

Abstract: A blockchain-based multi-merchant loyalty point partnership system may include a blockchain API host that is configured to generate a reward based at least in part on transaction data received from a web site. In one example, a system is configured to receive a loyalty account and transaction data for a completed purchase from a loyalty partner site. A partnership smart contract is executed to validate that the transaction data meets a purchase requirement parameter of the partnership smart contract. A transaction record is stored which indicates that the loyalty account has the transaction data for meeting the purchase requirement parameter. The transaction record is transmitted to consensus participants associated with the blockchain network.

Abstract: A blockchain-based multi-merchant loyalty point partnership system may include a blockchain API host that receives a request to create a partnership smart contract for a multi-merchant loyalty point partnership. The request may specify various partnership parameters to include in the partnership smart contract. The blockchain API host may create the partnership smart contract and write the partnership smart contract to a blockchain. One or more qualified merchants may join the partnership smart contract to make the partnership active. In response to a customer completing a plurality of purchases that complete the partnership parameters of the partnership smart contract, the system may issue the customer a purchase reward which may include a loyalty point payout.

Abstract: The present disclosure relates in some aspects to methods, cells, and compositions for preparing cells and compositions for genetic engineering and cell therapy. Provided in some embodiments are streamlined cell preparation methods, e.g., for isolation, processing, incubation, and genetic engineering of cells and populations of cells. Also provided are cells and compositions produced by the methods and methods of their use. The cells can include immune cells, such as T cells, and generally include a plurality of isolated T cell populations or types. In some aspects, the methods are capable of preparing of a plurality of different cell populations for adoptive therapy using fewer steps and/or resources and/or reduced handling compared with other methods.

Abstract: Provided in some aspects are compositions of cells for treating subjects with disease and conditions such as non-Hodgkin's lymphoma (NHL), and related methods, compositions, uses and articles of manufacture. In some embodiments, the disease or condition is a B-cell non-Hodgkin lymphoma (B-cell NHL). The cells generally express recombinant receptors such as chimeric antigen receptors (CARs) for targeting an antigen, such as CD 19, on cells of the lymphoma.

Abstract: Provided herein are methods of producing engineered T cell compositions enriched for CD57 negative and/or CD27 positive T cells, such as from a plurality of donors. In some embodiments, the T cells are engineered with a recombinant receptor, such as a chimeric antigen receptor (CAR). Also provided herein are engineered T cell compositions containing T cells enriched for CD57 negative and/or CD27 positive T cells derived from a plurality of different donors, including compositions in which the T cells are engineered with or express a recombinant receptor (e.g. CAR). Also provided are methods of using the engineered T cell compositions in adoptive therapy, including in connection for cancer immunotherapy, such as for allogeneic therapies or for administration to one or more subjects in which the T cells are not derived from the subject(s) to whom the compositions are administered.

Abstract: A laser level includes a level body, the level body including a body housing and a laser light source contained in the body housing, the laser light source configured to emit a laser light beam plane so as to project a laser light line on a target surface, the laser light beam plane configured to form an adjustable angle relative to a horizontal plane, and the laser level including a fixing structure configured to fix the laser light source such that the laser light beam plane projected therefrom is fixed at an adjusted angle, the laser light line providing a levelling height when in a horizontal state. The laser level further includes an adjustment means configured to adjust the attitude of the laser light source when the laser light line projected onto the target surface from the laser light source from a non-horizontal state to a horizontal state.

Abstract: Provided herein are methods of assessing or determining the presence or absence of particles, such as bead particles, present in a cell composition. Also provided are articles of manufacture and kits for use in the methods.

Abstract: The present disclosure relates in some aspects to methods, cells, and compositions for preparing cells and compositions for genetic engineering and cell therapy. Provided in some embodiments are streamlined cell preparation methods, e.g., for isolation, processing, incubation, and genetic engineering of cells and populations of cells. Also provided are cells and compositions produced by the methods and methods of their use. The cells can include immune cells, such as T cells, and generally include a plurality of isolated T cell populations or types. In some aspects, the methods arc capable of preparing of a plurality of different cell populations for adoptive therapy using fewer steps and/or resources and/or reduced handling compared with other methods.

Abstract: Provided in some aspects are compositions of cells for treating subjects with disease and conditions such as multiple myeloma (MM), and related methods, compositions, uses and articles of manufacture. In some embodiments, the disease or condition is a relapsed or refractory multiple myeloma (r/r MM). The cells generally express recombinant receptors such as chimeric antigen receptors (CARs) for targeting an antigen, such as BCMA, on cells of the myeloma.

Abstract: A laser leveling device includes at least one laser emitting device for emitting a laser marking, in particular a one-dimensional laser marking, in an emission direction onto a projection surface. The laser emitting device includes a first sensor device for ascertaining the actual alignment of the at least one laser emitting device with respect to the projection surface, a controller which is designed to calculate a target alignment of the at least one laser emitting device at least on the basis of the ascertained actual alignment of the at least one laser emitting device with respect to the projection surface, and a positioning device for aligning the at least one laser emitting device according to the target alignment. The disclosure additionally relates to a leveling method.

Abstract: Provided herein are methods of assessing or determining the presence or absence of particles, such as bead particles, present in a cell composition. Also provided are articles of manufacture and kits for use in the methods.

Abstract: A blockchain-based loyalty point distribution system may be configured to provide decentralized loyalty IDs. In one example, a system comprising a computing device that is configured to determine that a reward event has been initiated by a user and invoke executable code to display a user interface for selecting a loyalty provider for storing the reward event. The loyalty provider for storing the reward event is identified and the executable code is invoked to display a login page for the selected loyalty provider. A loyalty ID is determined and a customer reward to be written to a blockchain based at least in part on a public key.

Abstract: The present disclosure relates in some aspects to methods, cells, and compositions for preparing cells and compositions for genetic engineering and cell therapy. Provided in some embodiments are streamlined cell preparation methods, e.g., for isolation, processing, incubation, and genetic engineering of cells and populations of cells. Also provided are cells and compositions produced by the methods and methods of their use. The cells can include immune cells, such as T cells, and generally include a plurality of isolated T cell populations or types. In some aspects, the methods are capable of preparing of a plurality of different cell populations for adoptive therapy using fewer steps and/or resources and/or reduced handling compared with other methods.

Abstract: A blockchain-based loyalty point distribution system may be configured to provide decentralized loyalty IDs. The decentralized loyalty IDs may allow distribution of loyalty rewards in response to transaction-based events and non-transaction-based events, including behavioral interactions. The system may include a loyalty partner system that receives a rewards event from a customer. The loyalty partner system may determine a loyalty ID associated with the customer, and write the rewards event to the blockchain. A loyalty provider system may receive notification of the rewards event write and distribute the loyalty reward to the customer. The loyalty provider may instruct the loyalty partner to remit payment for the loyalty reward, and may update customer and loyalty partner balances on the blockchain.

Abstract: An instrumentation analysis system processes data streams received from servers executing instrumented software. The system determines a set of servers that satisfy a given criteria, for example, a set of servers with high resource utilization. The set of servers may be determined by the system based on triggers or specified by a user. The system analyzes properties of servers to determine a property that characterizes the set of servers. The property characterizing the servers is provided to users via a user interface or alerts for further analysis, for example, to analyze the cause of high resource utilization.

Abstract: A laser level includes a level body, the level body including a body housing and a laser light source contained in the body housing, the laser light source configured to emit a laser light beam plane so as to project a laser light line on a target surface, the laser light beam plane configured to form an adjustable angle relative to a horizontal plane, and the laser level including a fixing structure configured to fix the laser light source such that the laser light beam plane projected therefrom is fixed at an adjusted angle, the laser light line providing a levelling height when in a horizontal state. The laser level further includes an adjustment means configured to adjust the attitude of the laser light source when the laser light line projected onto the target surface from the laser light source from a non-horizontal state to a horizontal state.

Abstract: A laser leveling tool comprising: gesture control means comprises at least one sensor adapted to sense gestures and/or movements of a user; and a controller in communication with the gesture control means for receiving signals from the sensor and generating control commands for the tool based on the received signals, the control commands comprising at least ON/OFF states of laser beam patterns that the tool can project.